Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing.

Autor: Chen F; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Wang X; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Jang SK; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Quach BC; RTI International, Research Triangle, NC, USA., Weissenkampen JD; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Psychology, Penn State College of Medicine, Hershey, PA, USA., Khunsriraksakul C; Deparment of Bioinformatics and Genomics, Penn State College of Medicine, Hershey, PA, USA., Yang L; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Sauteraud R; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA., Albert CM; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Allred NDD; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, USA., Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA., Barnes KC; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Becker DM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Bis JC; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Boorgula MP; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chavan S; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Chen YI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chuang LM; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Correa A; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., David SP; University of Chicago, Chicago, IL, USA.; NorthShore University Health System, Evanston, IL, USA., de las Fuentes L; Department of Medicine, Division of Biostatistics and Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA., Deka R; Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA., Duggirala R; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Faul JD; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA., Garrett ME; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Gharib SA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Computational Medicine Core at Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA., Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Hawley NL; Department of Epidemiology (Chronic Disease), School of Public Health, Yale University, New Haven, CT, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Hobbs BD; Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Hokanson JE; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Hwang SJ; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; The Framingham Heart Study, Framingham, MA, USA., Hyde TM; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Jaffe AE; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Mental Health and Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Human Genetics and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Johnson EO; RTI International, Research Triangle, NC, USA., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, The Bronx, NY, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kaufman JD; Departments of Environmental & Occupational Health Sciences, Medicine, and Epidemiology, University of Washington Seattle, Seattle, WA, USA., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Kleinman JE; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kooperberg C; Fred Hutchinson Cancer Center, Seattle, WA, USA., Lee IT; Department of Internal Medicine, Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan., Levy D; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Lutz SM; Department of Population Medicine, Harvard Pilgrim Health Care, Boston, MA, USA., Manichaikul AW; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Martin LW; Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Marx O; Department of Biomedical Sciences, Penn State College of Medicine, Hershey, PA, USA., McGarvey ST; Department of Epidemiology, International Health Institute, Brown University School of Public Health, Providence, RI, USA., Minster RL; Department of Human Genetics and Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA., Moll M; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Moussa KA; Penn State Huck Institutes of Life Sciences, Penn State College of Medicine, University Park, PA, USA., Naseri T; Ministry of Health, Government of Samoa, Apia, Samoa., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Oelsner EC; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Peralta JM; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Psaty BM; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Rafaels N; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Reupena MS; Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Schwartz DA; Department of Medicine, University of Colorado, Aurora, CO, USA., Shadyab AH; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Sheu WH; Taipei Veterans General Hospital, Taipei, Taiwan., Sims M; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA., Sun X; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Taylor KD; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Telen MJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Watson H; Faculty of Medical Sciences, University of the West Indies, Cave Hill Campus, Barbados., Weeks DE; Department of Human Genetics and Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA., Weir DR; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Young KA; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Young KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA., Hancock DB; RTI International, Research Triangle, NC, USA., Jiang B; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. bjiang@phs.psu.edu., Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA. vrieze@umn.edu., Liu DJ; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. dajiang.liu@psu.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Feb; Vol. 55 (2), pp. 291-300. Date of Electronic Publication: 2023 Jan 26.