Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Allovectin-7"'
Publikováno v:
ImmunoTargets and Therapy, Vol 2013, Iss Issue 1, Pp 1-10 (2013)
Dylan Alston,1 Jerry D Brewer21Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, 2Mayo Clinic, Rochester, MN, USAAbstract: As the rate of melanoma continues to increase, so does the need for more effective and durable
Externí odkaz:
https://doaj.org/article/5d25519c88ff498c9bdb3a822ff788cd
Autor:
Claus Garbe, Noura Nouri
Publikováno v:
Expert Opinion on Biological Therapy. 16:619-626
Intralesional immunotherapy supplements systemic treatments and often achieves higher remission rates as compared to systemic therapy. Its indication is metastatic melanoma with limited tumor burden, particularly in loco-regional metastasis and dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6759d2da822eaccee1fb48f056089424
https://doi.org/10.1517/14712598.2016.1157161
https://doi.org/10.1517/14712598.2016.1157161
Autor:
Jerry D. Brewer, Dylan B. Alston
Publikováno v:
ImmunoTargets and Therapy
As the rate of melanoma continues to increase, so does the need for more effective and durable therapies. Despite considerable research, the management of advanced disease remains challenging. Numerous therapies are being investigated, many of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf5d9858f3e5f08ab1b270dbf0bae2a
http://europepmc.org/articles/PMC4928361
http://europepmc.org/articles/PMC4928361
Autor:
Agop Y. Bedikian, Eric D. Whitman, Dmitri D. Kharkevitch, Rene Gonzalez, Michael B. Atkins, Jon M. Richards
Publikováno v:
Melanoma Research. 20:218-226
Allovectin-7, a bicistronic plasmid encoding human leukocyte antigen-B7 and beta-2 microglobulin formulated with a cationic lipid system, is an immunotherapeutic agent designed to express allogeneic major histocompatibility complex class I antigen up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce98b2a24b443da12203c80b5004c07
https://doi.org/10.1097/cmr.0b013e3283390711
https://doi.org/10.1097/cmr.0b013e3283390711
Autor:
Alexander M.M. Eggermont
Publikováno v:
Annals of Oncology, 21, 339-344. Elsevier Ltd.
After decades of phase III trials failing to demonstrate an impact on survival of various drugs in metastatic melanoma there are finally significant advances in systemic therapies for melanoma emerging. Novel ways to modulate the immune system by mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e7ebdd5ed421daf725bb4196f81aa1
https://doi.org/10.1093/annonc/mdq364
https://doi.org/10.1093/annonc/mdq364
Publikováno v:
Expert Opinion on Biological Therapy. 3:377-384
Human leukocyte antigen (HLA)-B7/beta-2 microglobulin plasmid DNA/lipid complex, otherwise known as Allovectin-7 (Vical, Inc., San Diego, CA, USA), has been developed as a non-viral gene delivery product. After multiple laboratory and human trials, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85856ffea87df8cdb57257908ac9a033
https://doi.org/10.1517/14712598.3.2.377
https://doi.org/10.1517/14712598.3.2.377
Autor:
Robert Williams
Publikováno v:
Expert opinion on investigational drugs. 24(1)
Introduction: Attrition in clinical development is widely recognised as a key factor negatively impacting overall R&D efficiency. Gaining an understanding of the reasons for candidate failure may lead to improvements in success rates and return on R&
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0f929ddae3761db87d2caae07e1c47
https://pubmed.ncbi.nlm.nih.gov/25315907
https://pubmed.ncbi.nlm.nih.gov/25315907
Autor:
Rozina Chowdhery, Rene Gonzalez
Publikováno v:
Immunotherapy. 3(1)
In the USA, the incidence of cutaneous melanoma is increasing rapidly. It has been shown to be responsive to immune-stimulating drugs. Allovectin-7® allows the immune system to recognize metastatic melanoma lesions as foreign by incorporating a MHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c360a7d57c140c7a58a1f553f26fa0
https://pubmed.ncbi.nlm.nih.gov/21174553
https://pubmed.ncbi.nlm.nih.gov/21174553