Zobrazeno 1 - 10
of 5 665
pro vyhledávání: '"Allosteric modulator"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Insomnia is the most common sleep disorder in which an individual has trouble falling or staying asleep. Chronic sleep loss interferes with daily functioning and adversely affects health. The main clinical drugs for insomnia are the positive alloster
Externí odkaz:
https://doaj.org/article/93de1b36b3db4b6489ea8afa34cda86c
Autor:
I. R. Svechkareva, A. S. Kolbin
Publikováno v:
Реальная клиническая практика: данные и доказательства, Vol 3, Iss 4, Pp 15-21 (2023)
While the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic
Externí odkaz:
https://doaj.org/article/4a3dd77c29074c54b4bf0a4fdb0f49a7
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractCell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for
Externí odkaz:
https://doaj.org/article/a9474a61b420473c8be3cc0a61492459
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThe α6 subunit-containing GABAA receptors (α6GABAARs) are highly expressed in the trigeminal ganglia (TG), the sensory hub of the trigeminovascular system (TGVS). Hypo-GABAergic transmission in the TG was reported to contribute to migra
Externí odkaz:
https://doaj.org/article/9ce24f26600c4d24bc37ede64fe6fd4a
Autor:
Hong-Wei Dong, Kelly Weiss, Kathryn Baugh, Mac J. Meadows, Colleen M. Niswender, Jeffrey L. Neul
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00384- (2024)
Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the X chromosome-linked gene Methyl-CpG Binding Protein 2 (MECP2). Restoring MeCP2 expression after disease onset in a mouse model of RTT reverses phenotypes, provi
Externí odkaz:
https://doaj.org/article/662280363bb541b78198ddb9e19cb5b5
Autor:
Casey I. Gallagher, David P. Bishop, Thomas E. Lockwood, Tristan Rawling, Robert J. Vandenberg
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Zinc is a ubiquitous contaminant in many buffers, purified products and common labware that has previously been suggested to impact on the results of functional GlyR studies and may inadvertently cause the effectiveness of some GlyR modulators to be
Externí odkaz:
https://doaj.org/article/4d425daf67854576a2c4286ff073812a
Autor:
Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative compound fr
Externí odkaz:
https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea
Autor:
Fadime Canbolat, Nigar Kantarci-Carsibasi, Sevim Isik, Suhair Rami Mohammed Shamshir, Münteha Girgin
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 788-807 (2024)
Glutamate (Glu) toxicity has been an important research topic in toxicology and neuroscience studies. In vitro and in vivo studies have shown that Group II metabotropic Glu2 (mGlu2) activators have cell viability effects. This study aims to determine
Externí odkaz:
https://doaj.org/article/cf8c27840af140168fb82c319d01bc8f
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Autor:
Jiahui Chen, Wenqing Ran, Yiman Huang, Junjie Wei, Jian Rong, Huiyi Wei, Yinlong Li, Guocong Li, Zhen Chen, Lee Collier, Nehal H. Elghazawy, Wolfgang Sippl, Ahmed Haider, Kai Liao, Chenchen Dong, Ying Li, Hao Xu, Wenpeng He, Lu Wang, Steven H. Liang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115842- (2023)
As a subclass of ionotropic glutamate receptors (iGluRs), α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been implicated in various neurological disorders and neurodegenerative diseases. To further our understanding of A
Externí odkaz:
https://doaj.org/article/0c8e3714e4864fda9db485416e7f5b4f