Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells.

Autor: Zhang Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, 310003, China., Fang H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, 310003, China., Wang G; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, 310003, China., Yuan G; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, 310003, China., Dong R; Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China., Luo J; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.; Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, 310003, China., Lyu Y; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Hangzhou, 310058, China., Wang Y; Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058, China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China., Li P; Puluoting Health Technology Co., Ltd, Hangzhou, 310003, China., Zhou C; School of Public Health & Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China., Yin W; Key Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310058, China.; Department of Thoracic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China., Xiao H; Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China. haowenxiaoxiao@zju.edu.cn., Sun J; Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058, China. sunj4@zju.edu.cn.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China. sunj4@zju.edu.cn., Zeng X; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. xunzeng@zju.edu.cn.; Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, 310003, China. xunzeng@zju.edu.cn.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 20; Vol. 14 (1), pp. 8491. Date of Electronic Publication: 2023 Dec 20.

Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells

Autor: Yixi Zhang, Hongyu Fang, Guocan Wang, Guangxun Yuan, Ruoyu Dong, Jijun Luo, Yu Lyu, Yajie Wang, Peng Li, Chun Zhou, Weiwei Yin, Haowen Xiao, Jie Sun, Xun Zeng

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Chimeric antigen receptor (CAR)-T therapy requires autologous T lymphocytes from cancer patients, a process that is both costly and complex. Universal CAR-T cell treatment from allogeneic sources can overcome this limitation but is impeded b

Externí odkaz: https://doaj.org/article/2b27d29c26a64f5ea0f9eb0cf1c7b524

Vascular Remodeling of Clinically Used Patches and Decellularized Pericardial Matrices Recellularized with Autologous or Allogeneic Cells in a Porcine Carotid Artery Model.

Autor: Chlupac J; Transplantation Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic.; Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic.; Department of Anatomy, Second Faculty of Medicine, Charles University, V Uvalu 84, 15006 Prague, Czech Republic., Matejka R; Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Nam. Sitna 3105, 27201 Kladno, Czech Republic., Konarik M; Cardiovascular Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic.; Institute of Physiology, First Faculty of Medicine, Charles University, Albertov 5, 12800 Prague, Czech Republic., Novotny R; Transplantation Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Simunkova Z; Experimental Medicine Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Mrazova I; Experimental Medicine Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Fabian O; Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Zapletal M; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Pulda Z; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Lipensky JF; PrimeCell Bioscience, a.s., Dr. Slabihoudka 6232/11, Poruba, 70800 Ostrava, Czech Republic., Stepanovska J; Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Nam. Sitna 3105, 27201 Kladno, Czech Republic., Hanzalek K; Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Nam. Sitna 3105, 27201 Kladno, Czech Republic., Broz A; Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic., Novak T; Department of Anatomy, Second Faculty of Medicine, Charles University, V Uvalu 84, 15006 Prague, Czech Republic., Lodererova A; Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Voska L; Clinical and Transplant Pathology Centre, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Adla T; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic., Fronek J; Transplantation Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic.; Department of Anatomy, Second Faculty of Medicine, Charles University, V Uvalu 84, 15006 Prague, Czech Republic., Rozkot M; Department of Pig Breeding, Institute of Animal Science, Komenskeho 1239, 51741 Kostelec nad Orlici, Czech Republic., Forostyak S; PrimeCell Bioscience, a.s., Dr. Slabihoudka 6232/11, Poruba, 70800 Ostrava, Czech Republic., Kneppo P; Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Nam. Sitna 3105, 27201 Kladno, Czech Republic., Bacakova L; Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic., Pirk J; Cardiovascular Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 14021 Prague, Czech Republic.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Mar 18; Vol. 23 (6). Date of Electronic Publication: 2022 Mar 18.

Immune Responses to Sequential Binocular Transplantation of Allogeneic Retinal Progenitor Cells to the Vitreous Cavity in Mice.

Autor: Chen L; Department of Ophthalmology, University of California, 845 Health Sciences Road, Irvine, CA 92697, USA.; Enochian BioSciences, Los Angeles, CA 90036, USA., Yang J; Department of Ophthalmology, University of California, 845 Health Sciences Road, Irvine, CA 92697, USA.; jCyte, Inc., Newport Beach, CA 92660, USA., Klassen H; Department of Ophthalmology, University of California, 845 Health Sciences Road, Irvine, CA 92697, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 25; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 25.

Clones of Cytotoxic T Lymphocytes Reactive to Haptenated Allogeneic Cells: Precursor Frequency and Characteristics as Determined by a Split-Culture Approach

Autor: Good, Michael F., Nossal, G. J. V.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1983 Mar . 80(6), 1693-1697.

Externí odkaz: https://www.jstor.org/stable/13827