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Active compounds with antioxidant potential in boiled local Papua-Indonesian garlic

Autor: Betty Lukiati, Balqis, Widodo, Mohamad Amin

Publikováno v: AIP Conference Proceedings.

Garlic is a cultivated plant that has benefits as a cooking and medicinal spice. Garlic can be consumed fresh or in a processed state. As a cooking spice, garlic is generally boiled or heated. Garlic processing can damage the content of its active co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbb1804b40bcccb0636d4a5f4d50eb4c
https://doi.org/10.1063/1.5061848

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Action Mechanism of Insulin‐Mimetic Vanadyl–Allixin Complex

Autor: Hiromu Sakurai, Makoto Hiromura

Publikováno v: Chemistry & Biodiversity. 5:1615-1621

In the 21st century, there has been a dramatic worldwide increase in the prevalence of metabolic syndromes, including diabetes mellitus (DM). Several synthetic pharmaceutical agents have been developed and used for the treatment of type-2 DM; however

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a186b2b464d9c1eb62da049cea4c93d4
https://doi.org/10.1002/cbdv.200890149

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Molecular mechanism of antidiabetic zinc–allixin complexes: regulations of glucose utilization and lipid metabolism

Autor: Hiromu Sakurai, Akihiro Nakayama, Makoto Hiromura, Yusuke Adachi

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 13:675-684

We previously reported new zinc complexes of allixin [bis(allixinato)zinc] and its derivative bis(thioallixin-N-methyl)zinc that demonstrated excellent antidiabetic activity in type 2 diabetic mellitus KKA(y) mice. However, the molecular mechanism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998168175285a56bf3a87e74161c04e3
https://doi.org/10.1007/s00775-008-0352-0

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Action mechanism of metallo-allixin complexes as antidiabetic agents

Autor: Makoto Hiromura, Hiromu Sakurai

Publikováno v: Pure and Applied Chemistry. 80:2727-2733

The metabolic syndrome is a group of factors associated with an increased risk of atherosclerosis and diabetes. Diabetes mellitus (DM) is classified into 2 major types - type 1 DM and type 2 DM - characterized by chronic hyperglycemia resulting from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d807baca9ae65f52311708b8483b395a
https://doi.org/10.1351/pac200880122727

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Bis(allixinato)oxovanadium(IV) Complex Is a Potent Antidiabetic Agent: Studies on Structure−Activity Relationship for a Series of Hydroxypyrone−Vanadium Complexes

Autor: Yusuke Adachi, Akira Katoh, Hiromu Sakurai, Yukihiro Kodera, Jitsuya Takada, Jiro Yoshida

Publikováno v: Journal of Medicinal Chemistry. 49:3251-3256

There is an urgent medical need for orally effective drugs to replace insulin injections for the treatment of diabetes mellitus. Vanadium complexes with insulin-mimetic activities have recently been proposed as candidates as new antidiabetic drugs. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e367b7b2fce98f144fd38245476c8a
https://doi.org/10.1021/jm060229a

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Protective effect of S-allyl-l-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells

Autor: Motoki Arakawa, Eiko Yokoyama, Yasuhiro Kosuge, Kumiko Ishige, Kumiko Yamashina, Hiroshi Saito, Taeko Sakikubo, Yoshihisa Ito, Machiko Yamamoto, Kayo Horie, Natsue Ishikawa, Naoya Obokata

Publikováno v: Neuroscience Research. 46:119-125

Aged garlic extract (AGE) contains several neuroactive compounds, including S-allyl-L-cysteine (SAC) and allixin. We characterized cell death induced by amyloid beta-protein (Abeta), 4-hydroxynonenal (HNE), tunicamycin, an endoplasmic reticulum (ER)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4291a9c6f305f8d5d96e2ac1670872
https://doi.org/10.1016/s0168-0102(03)00037-3

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Structure based virtual screening of anticanerous polyphenolic phytocompounds against G-protein coupled receptor and identification of potent antagonist ligand(s) through molecular docking

Autor: Revathi Singaram, Sr Lilly, Daisy Pitchai, Rajalakshmi Manikkam

Publikováno v: Bioinformation

Design of potential drug-like candidates for cancer is of interest in recent years. We used 60 compounds which are known to have the potential to down regulate Nuclear Factor kappaB (NFκB) for this study. The compounds were assessed for Lipinski's R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c12caacd362bfdba1346e0be42ad28
https://doi.org/10.6026/97320630006226

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Metallo-allixinate complexes with anti-diabetic and anti-metabolic syndrome activities

Autor: Tamás Kiss, Hiromu Sakurai, Tamás Jakusch, Masakazu Hattori, Akira Katoh

Publikováno v: Metallomics : integrated biometal science. 2(10)

Metabolic syndrome and the accompanied diabetes mellitus are both important diseases worldwide due to changes of lifestyle and eating habits. The number of patients with diabetes worldwide is estimated to increase to 300 million by 2025 from 150–22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb33abfb563d7146633eee371a99659
https://pubmed.ncbi.nlm.nih.gov/21072358

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