Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Allison V. Mitchell"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Pancreatic adenocarcinoma is one of the most aggressive and lethal forms of cancer. Chemotherapy is the primary treatment for pancreatic cancer, but resistance to the drugs used remains a major challenge. A genome-wide CRISPR interference an
Externí odkaz:
https://doaj.org/article/0a01dade22474bd7b3f5843e572dede0
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
Autor:
Allison V. Mitchell, Ling Wu, C. James Block, Mu Zhang, Justin Hackett, Douglas B. Craig, Wei Chen, Yongzhong Zhao, Bin Zhang, Yongjun Dang, Xiaohong Zhang, Shengping Zhang, Chuangui Wang, Heather Gibson, Lori A. Pile, Benjamin Kidder, Larry Matherly, Zhe Yang, Yali Dou, Guojun Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Forkhead box transcription factor, FOXQ1 is reported to promote epithelial-mesenchymal transition (EMT) and cancer metastasis. Here the authors show that FOXQ1 recruits the KMT2/MLL histone methyltransferase complex as a transcriptional coactivator t
Externí odkaz:
https://doaj.org/article/fb2c929fd9f444428d14613bbb55b90c
Autor:
Fanyan Meng, Ling Wu, Lun Dong, Allison V. Mitchell, C. James Block, Jenney Liu, Haijun Zhang, Qing Lu, Won-min Song, Bin Zhang, Wei Chen, Jiani Hu, Jian Wang, Qifeng Yang, Maik Hüttemann, Guojun Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Triple-negative breast cancer is an aggressive form of the disease. Here, the authors identify EGFL9 as a mediator of metastasis in TNBC through interactions with cMET.
Externí odkaz:
https://doaj.org/article/389b81394bda4d2382c09db9e9b68fc5
Autor:
Guojun Wu, Jing Li, Bin Zhang, Won-min Song, C. James Block, Lun Dong, Fanyan Meng, Jason Wu, Allison V. Mitchell
Supplementary Figure 1. Gene ontology molecular function and PANTHER pathway enrichment analysis for genes uniquely dyregulated in HMLE/FOXQ1 and HMLE/SNAI1 cells. Supplementary Figure 2. Gene set enrichment analysis (GSEA) based on 2201 genes common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a90721f347d9f3c5fd8de750aef006d
https://doi.org/10.1158/2767-9764.22545702
https://doi.org/10.1158/2767-9764.22545702
Autor:
Guojun Wu, Jing Li, Bin Zhang, Won-min Song, C. James Block, Lun Dong, Fanyan Meng, Jason Wu, Allison V. Mitchell
Metabolomics analysis of comparison between BT549_NT and BT549_shDDR2 cell models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f544985f55b3d90b80ec2dc5d41377
https://doi.org/10.1158/2767-9764.22545705
https://doi.org/10.1158/2767-9764.22545705
Autor:
Guojun Wu, Jing Li, Bin Zhang, Won-min Song, C. James Block, Lun Dong, Fanyan Meng, Jason Wu, Allison V. Mitchell
Information of PCR primers for all gene tested and information for shRNA sequences for targeting several genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bfa4624bd922ac2aedd2a9e2e13b64
https://doi.org/10.1158/2767-9764.22545699.v1
https://doi.org/10.1158/2767-9764.22545699.v1
Autor:
Guojun Wu, Jing Li, Bin Zhang, Won-min Song, C. James Block, Lun Dong, Fanyan Meng, Jason Wu, Allison V. Mitchell
Metabolomics analysis of comparison between HMLE_FOXQ1 and HMLE_FOXQ1_shDDR2 cell models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fcc10822ed65009d95f8b066d9b59d
https://doi.org/10.1158/2767-9764.22545708
https://doi.org/10.1158/2767-9764.22545708
Autor:
Guojun Wu, Jing Li, Bin Zhang, Won-min Song, C. James Block, Lun Dong, Fanyan Meng, Jason Wu, Allison V. Mitchell
While multiple transcription factors (TF) have been recognized to drive epithelial–mesenchymal transition (EMT) in cancer, their interdependence and context-dependent functions are poorly understood. In this study, we show that FOXQ1 and SNAI1 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26840e938f1d7640044a7dabd00bb5ab
https://doi.org/10.1158/2767-9764.c.6551010.v1
https://doi.org/10.1158/2767-9764.c.6551010.v1
Autor:
Allison V. Mitchell, Jason Wu, Fanyan Meng, Lun Dong, C. James Block, Won-min Song, Bin Zhang, Jing Li, Guojun Wu
Publikováno v:
Cancer Res Commun
While multiple transcription factors (TF) have been recognized to drive epithelial–mesenchymal transition (EMT) in cancer, their interdependence and context-dependent functions are poorly understood. In this study, we show that FOXQ1 and SNAI1 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6941df692908cd46c2b98354c62dca
https://europepmc.org/articles/PMC9881645/
https://europepmc.org/articles/PMC9881645/
Autor:
Robert W. Robey, Christina M. Fitzsimmons, Wilfried M. Guiblet, William J.E. Frye, José M. González Dalmasy, Li Wang, Drake A. Russell, Lyn M. Huff, Andrew J. Perciaccante, Fatima Ali-Rahmani, Crystal C. Lipsey, Heidi M. Wade, Allison V. Mitchell, Siddhardha S. Maligireddy, David Terrero, Donna Butcher, Elijah F. Edmondson, Lisa M. Jenkins, Tatiana Nikitina, Victor B. Zhurkin, Amit K. Tiwari, Anthony D. Piscopio, Rheem A. Totah, Susan E. Bates, H. Efsun Arda, Michael M. Gottesman, Pedro J. Batista
Histone deacetylase inhibitors (HDACis) are part of a growing class of epigenetic therapies used for the treatment of cancer. While elevated levels of the efflux pump P-gp are associated within vitroresistance to romidepsin, this mechanism does not t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eab6c73a6fa5f6f5baa893e9093b0da
https://doi.org/10.1101/2022.10.07.511310
https://doi.org/10.1101/2022.10.07.511310