Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Allison Sheen"'
Autor:
Daniel R. Schmidt, Iva Monique T. Gramatikov, Allison Sheen, Christopher L. Williams, Martina Hurwitz, Laura E. Dodge, Edward Holupka, W. S. Kiger, Milton R. Cornwall-Brady, Wei Huang, Howard H. Mak, Kathleen S Cormier, Charlene Condon, K. Dane Wittrup, Ömer H. Yilmaz, Mary Ann Stevenson, Julian D. Down, Scott R. Floyd, Jatin Roper, Matthew G. Vander Heiden
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)
Abstract Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality therapy used in patients
Externí odkaz:
https://doaj.org/article/e2abc75b55aa4454ae9d147cefaedee3
Autor:
Noor Momin, K Dane Wittrup, Jordan A Stinson, Matheus Moreno M Passos Barbosa, Allison Sheen, Jordan Hampel, Elizabeth Fink, Rebecca Kamerer, Jonathan Samuelson, Rebecca Bernstein, Timothy Fan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/507acb8003e64bd99bc67468f7c5774d
Autor:
Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Engineered cytokine–based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic mu
Externí odkaz:
https://doaj.org/article/e315efdb0cc249018ebbc3ca54aedce4
Autor:
Allison Sheen, Yash Agarwal, Keith M. Cheah, Sarah C. Cowles, Jordan A. Stinson, Joseph R. Palmeri, Hadley D. Sikes, K. Dane Wittrup
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102766- (2023)
Catalase is an antioxidant enzyme that catalyzes the rapid conversion of hydrogen peroxide to water and oxygen. Use of catalase as a cancer therapeutic has been proposed to reduce oxidative stress and hypoxia in the tumor microenvironment, both activ
Externí odkaz:
https://doaj.org/article/bdc02fa1657a4226b9e43defbfbf2f40
Autor:
Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibo
Externí odkaz:
https://doaj.org/article/a3566e931b5d476ea29616b10d00f10c
Autor:
Jordan A. Stinson, Allison Sheen, Noor Momin, Jordan Hampel, Rebecca Bernstein, Rebecca Kamerer, Bahaa Fadl-Alla, Jonathan Samuelson, Elizabeth Fink, Timothy M. Fan, K. Dane Wittrup
Publikováno v:
Clinical Cancer Research. :OF1-OF13
Purpose: Cytokine therapies such as IL2 and IL12 suffer from impractically small therapeutic windows driven by their on-target, off-tumor activity, limiting their clinical potential despite potent antitumor effects. We previously engineered cytokines
Autor:
K. Dane Wittrup, Timothy M. Fan, Elizabeth Fink, Jonathan Samuelson, Bahaa Fadl-Alla, Rebecca Kamerer, Rebecca Bernstein, Jordan Hampel, Noor Momin, Allison Sheen, Jordan A. Stinson
IFN-γ and IL-10 individual replicates from Milliplex, healthy beagles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c6af5f7df56457860f568f0fd4cc81
https://doi.org/10.1158/1078-0432.22665321.v1
https://doi.org/10.1158/1078-0432.22665321.v1
Autor:
K. Dane Wittrup, Timothy M. Fan, Elizabeth Fink, Jonathan Samuelson, Bahaa Fadl-Alla, Rebecca Kamerer, Rebecca Bernstein, Jordan Hampel, Noor Momin, Allison Sheen, Jordan A. Stinson
Soft tissue sarcoma canine patient information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399106034b7a6d7b2e96872efe99de94
https://doi.org/10.1158/1078-0432.22665297
https://doi.org/10.1158/1078-0432.22665297
Autor:
K. Dane Wittrup, Timothy M. Fan, Elizabeth Fink, Jonathan Samuelson, Bahaa Fadl-Alla, Rebecca Kamerer, Rebecca Bernstein, Jordan Hampel, Noor Momin, Allison Sheen, Jordan A. Stinson
Supplementary Methods S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8845407dbc4b34850904a7b2df656ff5
https://doi.org/10.1158/1078-0432.22665306
https://doi.org/10.1158/1078-0432.22665306
Autor:
K. Dane Wittrup, Timothy M. Fan, Elizabeth Fink, Jonathan Samuelson, Bahaa Fadl-Alla, Rebecca Kamerer, Rebecca Bernstein, Jordan Hampel, Noor Momin, Allison Sheen, Jordan A. Stinson
Purpose:Cytokine therapies such as IL2 and IL12 suffer from impractically small therapeutic windows driven by their on-target, off-tumor activity, limiting their clinical potential despite potent antitumor effects. We previously engineered cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1200b3c1df59e506f68af46a40a5148f
https://doi.org/10.1158/1078-0432.c.6608868
https://doi.org/10.1158/1078-0432.c.6608868