355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses

Autor: Philip D Greenberg, Christopher A Klebanoff, Kim Nguyen, Gary Shapiro, Joshua Francis, Cheryl Black, Anthony Thomas, Meghan D Storlie, Allison P Drain, Nicholas Rouillard, Nathaniel Swanson, Santosh Narayan, Tyler Warner, Nicole Danek, Ken Gareau, James Parsons, Jinsheng Liang, Luhua Shen, Tanya Tetrault, Vince Nguyen, Iqraa Priyata, Sarah Vidyasagar, Xingyue He, Patrick J Browne, Rebecca C Lamothe, Gregory J Cost, Thomas M Schmitt, Smita S Chandran, Ankit Gupta, Damien Hallet, Loic Vincent

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/cf7222b351e14e179116c6bbe6cf91f4

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Autor: Johnathon N. Lakins, Thanh T. Pham, Ori Maller, Irene Acerbi, Andrew C. Nelson, Travis Nemkov, Hellen Kuasne, Allison P. Drain, Olöf Bjarnadottir, Igor Zakharevich, Morag Park, Brian Ruffell, J. Matthew Barnes, Kirk C. Hansen, Aastha Chauhan, E. Shelley Hwang, Valerie M. Weaver, Lisa M. Coussens, Aqsa Nasir, Alexander S. Barrett, Signe Borgquist, Jessica Gruenberg, Tina Gruosso, Peter Kabos, Zena Werb, Yunn Yi Chen

Publikováno v: Nature materials, vol 20, iss 4
Maller, O, Drain, A P, Barrett, A S, Borgquist, S, Ruffell, B, Zakharevich, I, Pham, T T, Gruosso, T, Kuasne, H, Lakins, J N, Acerbi, I, Barnes, J M, Nemkov, T, Chauhan, A, Gruenberg, J, Nasir, A, Bjarnadottir, O, Werb, Z, Kabos, P, Chen, Y-Y, Hwang, E S, Park, M, Coussens, L M, Nelson, A C, Hansen, K C & Weaver, V M 2021, ' Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression ', Nature Materials, vol. 20, no. 4, pp. 548-559 . https://doi.org/10.1038/s41563-020-00849-5
Nature materials

Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b763b8a68e3e138bcaa445e6a01a159
https://doi.org/10.1038/s41563-020-00849-5

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

Autor: Valerie M. Weaver, E. S. Hwang, Aastha Chauhan, Brian Ruffell, Jonathan N. Lakins, Lisa M. Coussens, O. Maller, P. T. Thanh, Zena Werb, Peter Kabos, Travis Nemkov, Alexander S. Barrett, Tina Gruosso, Allison P. Drain, Olöf Bjarnadottir, Hellen Kuasne, Jessica Gruenberg, Andrew C. Nelson, Irene Acerbi, Morag Park, J. M. Barnes, Kirk C. Hansen, Signe Borgquist, Aqsa Nasir

Collagen deposition and stromal stiffening accompany malignancy, compromise treatment, and promote tumor aggression. Clarifying the molecular nature of and the factors that regulate extracellular matrix stiffening in tumors should identify biomarkers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd269832452581ee5a56d2c868d8294
https://doi.org/10.1101/2020.02.13.948141

Matrix molecules and their ligands

Autor: Allison P. Drain, Valerie M. Weaver

The extracellular matrix (ECM) dictates cell behavior and controls tissue structure and organization. Tissues finely tune their unique ECM biochemical and biomechanical properties through the production of different matrix molecules including collage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ffa4311d72279d164db630bab6a0c75
https://doi.org/10.1016/b978-0-12-818422-6.00008-3

The extracellular matrix modulates the metastatic journey

Autor: Valerie M. Weaver, Allison P. Drain, FuiBoon Kai

Publikováno v: Dev Cell
Developmental cell, vol 49, iss 3

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b55d80a0d4b2c30a6558500b13898ef
https://europepmc.org/articles/PMC6527347/