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pro vyhledávání: '"Allison Oberholtzer"'
Autor:
David M. Knight, Jennifer L. Luongo, Allison Oberholtzer, Diane D. Petrone, Tam Susan H, Omid Vafa, Randall J. Brezski, Robert Jordan, Gordon E. Powers, Mary Ryan
Publikováno v:
Proceedings of the National Academy of Sciences. 106:17864-17869
The successful elimination of pathogenic cells and microorganisms by the humoral immune system relies on effective interactions between host immunoglobulins and Fcγ receptors on effector cells, in addition to the complement system. Essential Ig moti
Autor:
Zhiqiang An, Ming Fa, Anneliese Gonzalez, Hui Deng, William P. Dubinsky, Allison Oberholtzer, Ningyan Zhang, Randall J. Brezski, Xuejun Fan, Robert Jordan, William R. Strohl
Publikováno v:
Breast Cancer Research : BCR
Introduction Recent studies reported that human IgG antibodies are susceptible to specific proteolytic cleavage in their lower hinge region, and the hinge cleavage results in a loss of Fc-mediated effector functions. Trastuzumab is a humanized IgG1 t
Publikováno v:
mAbs. 3(6)
The mammalian antibody repertoire comprises immunoglobulin (Ig) molecules of multiple isotypes and subclasses with varying functional properties. Among the four subclasses of the human IgG isotype, we found that IgG2 exhibits a particular resistance