Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor.

Autor: Alessandra Ravidà, Allison M Aldridge, Nicole N Driessen, Ferry A H Heus, Cornelis H Hokke, Sandra M O'Neill

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004601 (2016)

Fascioliasis, caused by the liver fluke Fasciola hepatica, is a neglected tropical disease infecting over 1 million individuals annually with 17 million people at risk of infection. Like other helminths, F. hepatica employs mechanisms of immune suppr

Externí odkaz: https://doaj.org/article/75175387d6e54422a885a61546438b4a

Mast cells: new therapeutic target in helminth immune modulation

Autor: Sandra M. O’Neill, Allison M. Aldridge, Richard Lalor, Krisztina V. Vukman

Publikováno v: Parasite Immunology. 38:45-52

Helminth infection and their secreted antigens have a protective role in many immune-mediated inflammatory disorders such as inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. However, studies have focused primarily on identifyi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d5eeda81aa8aa644a5cafc3a167517
https://doi.org/10.1111/pim.12295

Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host

Autor: Allison M. Aldridge, Roisin Thompson, John P. Dalton, Sandra M. O’Neill, Paul M. Clarke, Michelle Kilcoyne, Alessandra Ravidà, Jared Q. Gerlach, Krystyna Cwiklinski, Cornelis H. Hokke

Publikováno v: Molecular and Cellular Proteomics, 15(10), 3139-3153
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & Cellular Proteomics
Ravida, A, Cwiklinski, K, Aldridge, A M, Clarke, P, Thompson, R, Gerlach, J Q, Kilcoyne, M, Hokke, C H, Dalton, J P & O'Neill, S M 2016, ' Fasciola hepatica surface tegument: glycoproteins at the interface of parasite and host ', Molecular and Cellular Proteomics . https://doi.org/10.1074/mcp.M116.059774

© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Fasciola hepatica, commonly known as liver fluke, is a trematode that causes Fasciolosis in ruminants and humans. The outer tegumental coat of F. hepatica (FhTeg) is a compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a20a2822a314f256210596355870858
https://hdl.handle.net/1887/111919

Fasciola hepatica tegumental antigens indirectly induce an M2 macrophage-like phenotype in vivo

Autor: Sheila Donnelly, Sandra M. O’Neill, Krisztina V. Vukman, Allison M. Aldridge, Paul N. Adams

Publikováno v: Parasite immunology. 36(10)

Summary The M2 subset of macrophages has a critical role to play in host tissue repair, tissue fibrosis and modulation of adaptive immunity during helminth infection. Infection with the helminth, Fasciola hepatica, is associated with M2 macrophages i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78033843901d8cf23e5a11d8382ed820
https://pubmed.ncbi.nlm.nih.gov/25039932