Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Allison L. Brill"'
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1134-1151 (2020)
Changes in intracellular calcium (Ca2+) signaling can modulate cellular machinery required for cancer progression. Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed Ca2+‐binding protein that promotes tumor aggressiveness by enhancing cel
Externí odkaz:
https://doaj.org/article/720596b58db84d30b843d6598f2e2451
Autor:
Rachel J. Fenske, Alicia M. Weeks, Michael Daniels, Randall Nall, Samantha Pabich, Allison L. Brill, Darby C. Peter, Margaret Punt, Elizabeth D. Cox, Dawn Belt Davis, Michelle E. Kimple
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1234 (2022)
Over half of patients with type 2 diabetes (T2D) are unable to achieve blood glucose targets despite therapeutic compliance, significantly increasing their risk of long-term complications. Discovering ways to identify and properly treat these individ
Externí odkaz:
https://doaj.org/article/08a0b32c202b471e9122aef220854e8f
Autor:
Marcos A. Carpio, Robert E. Means, Allison L. Brill, Alva Sainz, Barbara E. Ehrlich, Samuel G. Katz
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108827- (2021)
Summary: Calcium transfer from the endoplasmic reticulum (ER) to mitochondria is a critical contributor to apoptosis. B cell lymphoma 2 (BCL-2) ovarian killer (BOK) localizes to the ER and binds the inositol 1,4,5-trisphosophate receptor (IP3R). Here
Externí odkaz:
https://doaj.org/article/0112185d44f6429c96a76b7675b36153
Autor:
Rachel J, Fenske, Alicia M, Weeks, Michael, Daniels, Randall, Nall, Samantha, Pabich, Allison L, Brill, Darby C, Peter, Margaret, Punt, Elizabeth D, Cox, Dawn Belt, Davis, Michelle E, Kimple
Publikováno v:
Metabolites. 12(12)
Over half of patients with type 2 diabetes (T2D) are unable to achieve blood glucose targets despite therapeutic compliance, significantly increasing their risk of long-term complications. Discovering ways to identify and properly treat these individ
Autor:
Austin Reuter, Samantha Pabich, Rachel J. Fenske, Alicia M Weeks, Dawn Belt Davis, Chinmai Patibandla, Elizabeth D. Cox, Harpreet K Sandhu, Randall Nall, Cecilia E Kaiser, Margaret Punt, Nathan A. Truchan, Allison L. Brill, Michelle E. Kimple, Darby C. Peter, Benjamin Wancewicz, Ying Ge, Jeffrey M. Harrington, Michael Daniels
Publikováno v:
ACS Pharmacol Transl Sci
We and others previously reported increased signaling through the Prostaglandin E3 Receptor (EP3), a G protein-coupled receptor (GPCR) for the arachidonic acid metabolite, prostaglandin E2 (PGE2), is associated with {beta}-cell dysfunction of type 2
Autor:
Aviva Rabin-Court, Sylvie Dufour, Ye Zhang, Ali Nasiri, Xian-Man Zhang, Liang Peng, Gary W. Cline, Gina M. Butrico, Leigh Goedeke, Keshia Toussaint, Rachel J. Perry, Gerald I. Shulman, Allison L. Brill, Michael H. Nathanson, Dongyan Zhang, Yongliang Wang, Yuichi Nozaki, Barbara E. Ehrlich, Kitt Falk Petersen, Mateus T. Guerra
Publikováno v:
Nature. 579:279-283
Although it is well-established that reductions in the ratio of insulin to glucagon in the portal vein have a major role in the dysregulation of hepatic glucose metabolism in type-2 diabetes1–3, the mechanisms by which glucagon affects hepatic gluc
Autor:
Marie E. Robert, Stuart G. Campbell, Allison L. Brill, Parker C. Wilson, Arnaud Marlier, Gilbert W. Moeckel, Tom T. Fischer, Hee Jung Chung, Jeanne M. Nerbonne, Barbara E. Ehrlich, Eric K. Johnson, Lorenzo R. Sewanan, Jennifer M. Walters, Lloyd G. Cantley
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Polycystin 2 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic reticulum (ER) membrane and primary cilia of all cell and tissue types. Despite its ubiquitous
Autor:
Ronald Ng, Allison L. Brill, Lorenzo R. Sewanan, Yibing Qyang, Stuart G. Campbell, Barbara E. Ehrlich, Xia Li, Paul Stankey
Publikováno v:
Am J Physiol Heart Circ Physiol
Engineered heart tissues (EHTs) have emerged as a robust in vitro model to study cardiac physiology. Although biomimetic culture environments have been developed to better approximate in vivo conditions, currently available methods do not permit full
Autor:
Mark Cadena, Quincy Eckert Harenda, Michelle E. Kimple, Harpreet K. Brar, Erin Laundre, Jaclyn A. Wisinski, Haley Wienkes, Rachel J. Fenske, Feyza Engin, Kathryn A. Carbajal, Jinjin Cai, Allison L. Brill, Timothy E. Graham, Michael D. Schaid, Nathan A. Truchan
Publikováno v:
Endocrinology. 158:1645-1658
The α-subunit of the heterotrimeric Gz protein, Gαz, promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gαz protein would preserve functional β-cell mass
Autor:
Jeffrey L. Falcone, David L. Kaplan, Fernanda O. Lemos, Allison L. Brill, Ivana Y. Kuo, Jason Y. Jiang, Ke Dong, Darren P. Wallace, Yiqiang Cai, Aldebaran M. Hofer, Barbara E. Ehrlich, Erica P. Kimmerling
Publikováno v:
Science Signaling. 12
Mitochondria and the endoplasmic reticulum (ER) have an intimate functional relationship due to tethering proteins that bring their membranes in close (~30 nm) apposition. One function of this interorganellar junction is to increase the efficiency of