Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Allison L. Bayer"'
Autor:
Ying Li, Anthony W. Frei, Irayme M. Labrada, Yanan Rong, Jia-Pu Liang, Magdalena M. Samojlik, Chuqiao Sun, Steven Barash, Benjamin G. Keselowsky, Allison L. Bayer, Cherie L. Stabler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Allogeneic islet transplantation is a promising cell-based therapy for Type 1 Diabetes (T1D). The long-term efficacy of this approach, however, is impaired by allorejection. Current clinical practice relies on long-term systemic immunosuppression, le
Externí odkaz:
https://doaj.org/article/320ef7a04b384cbfa75532b3502888b2
The Folate Cycle As a Cause of Natural Killer Cell Dysfunction and Viral Etiology in Type 1 Diabetes
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
The folate pathway is critical to proper cellular function and metabolism. It is responsible for multiple functions, including energy (ATP) production, methylation reactions for DNA and protein synthesis and the production of immunomodulatory molecul
Externí odkaz:
https://doaj.org/article/8dd6e55972d24c4c92c8f52dd52d386e
Autor:
Flavia, Zisi Tegou, Diana, Velluto, Aaron A, Stock, Samantha N, Fitzgerald, Samuel, Stealey, Silviya P, Zustiak, Allison L, Bayer, Alice A, Tomei
Publikováno v:
Journal of Controlled Release. 348:499-517
Type-I Diabetes (T1D) is caused by defective immunotolerance mechanisms enabling autoreactive T cells to escape regulation in lymphoid organs and destroy insulin-producing β-cells in the pancreas, leading to insulin dependence. Strategies to promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637760113c1d0bf4499a050a5ecee66a
https://doi.org/10.1016/j.jconrel.2022.06.008
https://doi.org/10.1016/j.jconrel.2022.06.008
Autor:
Melanie R. Shapiro, Leeana D. Peters, Matthew E. Brown, Cecilia Cabello-Kindelan, Amanda L. Posgai, Allison L. Bayer, Todd M. Brusko
IL-2 has been proposed to restore tolerance via regulatory T cell (Treg) expansion in autoimmunity, yet off-target effects necessitate identification of a combinatorial approach. We recently reported reduced levels of immunoregulatory insulin-like gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b79a8f9af04fed1e8aee664aa30dccd
https://doi.org/10.1101/2022.05.12.491665
https://doi.org/10.1101/2022.05.12.491665
Autor:
Alexander Sands, Allison L. Bayer, Jennifer Rodriguez, Cecilia Cabello-Kindelan, Alberto Pugliese, Shane Mackey, Claudia Vazquez
Publikováno v:
Diabetes. 69:215-227
Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d50d1c95b0ad7690960dd53190b3de8
https://doi.org/10.2337/db19-0061
https://doi.org/10.2337/db19-0061
Autor:
Ying, Li, Anthony W, Frei, Ethan Y, Yang, Irayme, Labrada-Miravet, Chuqiao, Sun, Yanan, Rong, Magdalena M, Samojlik, Allison L, Bayer, Cherie L, Stabler
Publikováno v:
Biomaterials
The curative potential of non-autologous cellular therapy is hindered by the requirement of anti-rejection therapy. Cellular encapsulation within nondegradable biomaterials has the potential to inhibit immune rejection, but the efficacy of this appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5e4e32ffd938d12817b1503c48e1fa6
https://pubmed.ncbi.nlm.nih.gov/32599358
https://pubmed.ncbi.nlm.nih.gov/32599358
Autor:
Vita Manzoli, Chiara Villa, R. Damaris Molano, Jeffrey A. Hubbell, Laura C. Morales, Allison L. Bayer, Alice A. Tomei, Camillo Ricordi, Yvan Torrente
Publikováno v:
American Journal of Transplantation. 18:590-603
Islet encapsulation may allow transplantation without immunosuppression but thus far islets in large microcapsules transplanted in the peritoneal cavity failed to reverse diabetes in humans. We showed that islet transplantation in confined well-vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2e36b916df5a02a7955284445fa4cd
https://doi.org/10.1111/ajt.14547
https://doi.org/10.1111/ajt.14547
Autor:
Shane H. Wright, Mejdi Najjar, Alberto Pugliese, Flavia Zisi Tegou, Alice A. Tomei, Divya Sha, Riccardo Masina, Maria M. Abreu, R. Damaris Molano, Eva Korpos, Allison L. Bayer, Freddy E. Gonzalez Badillo
Publikováno v:
Diabetes
Tumors induce tolerance toward their antigens by producing the chemokine CCL21, leading to the formation of tertiary lymphoid organs (TLOs). Ins2-CCL21 transgenic, nonobese diabetic (NOD) mice express CCL21 in pancreatic β-cells and do not develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4f3293d2b81849091fe639a5121517
https://pubmed.ncbi.nlm.nih.gov/31371518
https://pubmed.ncbi.nlm.nih.gov/31371518
Autor:
Cecilia, Cabello-Kindelan, Shane, Mackey, Alexander, Sands, Jennifer, Rodriguez, Claudia, Vazquez, Alberto, Pugliese, Allison L, Bayer
Publikováno v:
Diabetes
Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4(+)Foxp3(+) regulatory T cells (T(regs)) are a key cell population capable of facilitating durable immune tolerance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55ea6a70ee5ff0b3d448d8077ba8946d
https://pubmed.ncbi.nlm.nih.gov/31712320
https://pubmed.ncbi.nlm.nih.gov/31712320
Autor:
Chuqiao Sun, Cherie L. Stabler, Magdalena M. Samojlik, Ying Li, Anthony W. Frei, Yanan Rong, Allison L. Bayer, Irayme Labrada-Miravet, Ethan Y. Yang
Publikováno v:
Biomaterials. 256:120182
Cell replacement therapy has the potential to cure diseases caused by the absence or malfunction of specialized cells. A substantial impediment to the success of any non-autologous cellular transplant is the need for systemic immunosuppressive drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c354099a81db21e99e2ff36b434f2d93
https://doi.org/10.1016/j.biomaterials.2020.120182
https://doi.org/10.1016/j.biomaterials.2020.120182