Výsledky vyhledávání - "Allison Kriel"

Akademický článek

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

Autor: Marie A. Hanebuth, Roman Kityk, Sandra J. Fries, Alok Jain, Allison Kriel, Veronique Albanese, Tancred Frickey, Christine Peter, Matthias P. Mayer, Judith Frydman, Elke Deuerling

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs eff

Externí odkaz: https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3

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Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

Autor: Véronique Albanèse, Roman Kityk, Marie Anne Hanebuth, Matthias P. Mayer, Tancred Frickey, Alok Jain, Elke Deuerling, Sandra J. Fries, Christine Peter, Allison Kriel, Judith Frydman

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications

Hsp70 chaperones assist de novo folding of newly synthesized proteins in all cells. In yeast, the specialized Hsp70 Ssb directly binds to ribosomes. The structural basis and functional mode of recruitment of Ssb to ribosomes is not understood. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d492158a3e7609822ea92189958e17
https://doaj.org/article/45bf1ec4fc9046fa86502a2fa61438d3

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Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

Autor: Judith Frydman, Allison Kriel, Kevin C. Stein

Publikováno v: Mol Cell

Summary Cotranslational protein folding requires assistance from elaborate ribosome-associated chaperone networks. It remains unclear how the changing information in a growing nascent polypeptide dictates the recruitment of functionally distinct chap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63954975f5c913a025c9f52cc16804f
https://doi.org/10.1016/j.molcel.2019.06.036

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GTP Dysregulation in Bacillus subtilis Cells Lacking (p)ppGpp Results in Phenotypic Amino Acid Auxotrophy and Failure To Adapt to Nutrient Downshift and Regulate Biosynthesis Genes

Autor: Ashley K. Tehranchi, Abraham L. Sonenshein, Shaun R. Brinsmade, Allison Kriel, Alycia N. Bittner, Jue D. Wang, Jessica L. Tse

Publikováno v: Journal of Bacteriology. 196:189-201

The nucleotide (p)ppGpp inhibits GTP biosynthesis in the Gram-positive bacterium Bacillus subtilis. Here we examined how this regulation allows cells to grow in the absence of amino acids. We showed that B. subtilis cells lacking (p)ppGpp, due to eit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c776b6f1add039dc83565db6ef67b7a
https://doi.org/10.1128/jb.00918-13

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Lowering GTP Level Increases Survival of Amino Acid Starvation but Slows Growth Rate for Bacillus subtilis Cells Lacking (p)ppGpp

Autor: Allison Kriel, Alycia N. Bittner, Jue D. Wang

Bacterial cells sense external nutrient availability to regulate macromolecular synthesis and consequently their growth. In the Gram-positive bacterium Bacillus subtilis, the starvation-inducible nucleotide (p)ppGpp negatively regulates GTP levels, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec83b017107951f24e093450653f6899
https://europepmc.org/articles/PMC4010990/

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Failsafe mechanisms couple division and DNA replication in bacteria

Autor: Allison Kriel, Jue D. Wang, Petra Anne Levin, Jared T. Shaw, Nohemy A. Sorto, Heidi A. Arjes

Publikováno v: Current biology : CB, vol 24, iss 18
Arjes, HA; Kriel, A; Sorto, NA; Shaw, JT; Wang, JD; & Levin, PA. (2014). Failsafe mechanisms couple division and DNA replication in bacteria. Current Biology, 24(18), 2149-2155. doi: 10.1016/j.cub.2014.07.055. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5795z0tz

SummaryThe past 20 years have seen tremendous advances in our understanding of the mechanisms underlying bacterial cytokinesis, particularly the composition of the division machinery and the factors controlling its assembly [1]. At the same time, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e24f220e97d444396d15cde36e2e0d9
https://pubmed.ncbi.nlm.nih.gov/25247357

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Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance

Autor: Winnie Y. Zou, Jue D. Wang, Alycia N. Bittner, Benjamin P. Tu, Kuanqing Liu, Samantha Rendon, Ashley K. Tehranchi, Sok Ho Kim, Allison Kriel, Rui Chen

Publikováno v: Molecular cell. 48(2)

Cells constantly adjust their metabolism in response to environmental conditions, yet major mechanisms underlying survival remain poorly understood. We discover a post-transcriptional mechanism that integrates starvation response with GTP homeostasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e435783287b616acb9a1c8f61083dbc6
https://pubmed.ncbi.nlm.nih.gov/22981860

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