Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Allison J. Farrand"'
Autor:
Hunter L. Abrahamsen, Tristan C. Sanford, Casie E. Collamore, Bronte A. Johnstone, Michael J. Coyne, Leonor García-Bayona, Michelle P. Christie, Jordan C. Evans, Allison J. Farrand, Katia Flores, Craig J. Morton, Michael W. Parker, Laurie E. Comstock, Rodney K. Tweten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which are used to attack eukaryotic cells. Here, we functionally characterize a family of 2-component CDC-like (CDCL)
Externí odkaz:
https://doaj.org/article/fa81631103bf486aa966a456bbef1768
Autor:
Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions. U
Externí odkaz:
https://doaj.org/article/7bf35b5ddc6847bfb07b9a7eda692855
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Metals are a limiting resource for pathogenic bacteria and must be scavenged from host proteins. Hemoglobin provides the most abundant source of iron in the human body and is required by several pathogens to cause invasive disease. However,
Externí odkaz:
https://doaj.org/article/1ffa2eb9911b43c3946feb116ac169b2
Autor:
Lisa J. Lojek, Allison J. Farrand, Jennifer H. Wisecaver, Crysten E. Blaby-Haas, Brian W. Michel, Sabeeha S. Merchant, Antonis Rokas, Eric P. Skaar
Publikováno v:
mSphere, Vol 2, Iss 4 (2017)
ABSTRACT Heme is essential for respiration across all domains of life. However, heme accumulation can lead to toxicity if cells are unable to either degrade or export heme or its toxic by-products. Under aerobic conditions, heme degradation is perfor
Externí odkaz:
https://doaj.org/article/e779373f48724f7fbad545b38962453b
Autor:
Jesse McCool, Antoine Khoury, David Schmidt, Aaron Martin, Kevin Han, Dawn M Ecker, Tiffany D Rau, Allison J. Farrand, Nicholas A. Treuheit, Frank K. Agbogbo, Ma Sha, Ulrike Rasche
Publikováno v:
Journal of Industrial Microbiology & Biotechnology
In this work, an overview of the biosimilars market, pipeline and industry targets is discussed. Biosimilars typically have a shorter timeline for approval (8 years) compared to 12 years for innovator drugs and the development cost can be 10–20% of
Publikováno v:
International Journal of Medical Microbiology. 308:582-589
Heme is a cofactor that is essential for cellular respiration and for the function of many enzymes. If heme levels become too low within the cell, S. aureus switches from producing energy via respiration to producing energy by fermentation. S. aureus
Publikováno v:
mBio
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01524-18 (2018)
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01524-18 (2018)
During infection, bacteria must steal metals, including iron, from the host tissue. Therefore, pathogenic bacteria have evolved metal acquisition systems to overcome the elaborate processes mammals use to withhold metal from pathogens. Staphylococcus
Autor:
Allison J. Farrand, Nichole M. Lareau, Eric P. Skaar, Simon Heilbronner, Kathryn P. Haley, John A. McLean, Timothy J. Foster
Publikováno v:
Infection and Immunity. 83:3578-3589
Bacteria alter their cell surface in response to changing environments, including those encountered upon invasion of a host during infection. One alteration that occurs in several Gram-positive pathogens is the presentation of cell wall-anchored comp
Molecular basis for the evolution of species-specific hemoglobin capture by pathogenicStaphylococcus
Metals are a limiting resource for pathogenic bacteria and must be scavenged from host proteins. Hemoglobin provides the most abundant source of iron in the human body and is required by several pathogens to cause invasive disease. However, the conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c09d27397d1cff38e9ad1751bcc9184
https://doi.org/10.1101/339705
https://doi.org/10.1101/339705
Autor:
Kristin R. Wade, Eileen M. Hotze, Rodney K. Tweten, Takehiro K. Sato, William C. Wimley, Allison J. Farrand, Arthur E. Johnson
Publikováno v:
Journal of Biological Chemistry. 290:17733-17744
The majority of cholesterol-dependent cytolysins (CDCs) utilize cholesterol as a membrane receptor, whereas a small number are restricted to the GPI-anchored protein CD59 for initial membrane recognition. Two cholesterol-binding CDCs, perfringolysin