Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Allison H. Kowalsky"'
Autor:
Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and in
Externí odkaz:
https://doaj.org/article/126b3fa1af5449268749287ab60d04c0
Autor:
Sumeet Solanki, Katherine Sanchez, Varun Ponnusamy, Vasudha Kota, Hannah N. Bell, Chun-Seok Cho, Allison H. Kowalsky, Michael Green, Jun Hee Lee, Yatrik M. Shah
Publikováno v:
Gastroenterology.
Colorectal cancer (CRC) is a devastating disease that is highly modulated by dietary nutrients. Mechanistic target of rapamycin complex 1 (mTORC1) contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism
Autor:
Jun Hee Lee, Allison H. Kowalsky, Seung-Hyun Ro, Alyson Sujkowski, Susan V. Brooks, Carol S. Davis, Bondong Gu, Robert Wessells, Sim Namkoong, Michael Karin, Myungjin Kim, Ian A. Semple, Tyler Cobb, Boyoung Kim, Chun-Seok Cho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways m
Publikováno v:
Annu Rev Physiol
Sestrins are a family of proteins that respond to a variety of environmental stresses, including genotoxic, oxidative, and nutritional stresses. Sestrins affect multiple signaling pathways: AMP-activated protein kinase, mammalian target of rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef0e5f26abba307889902aeea1032a5
https://europepmc.org/articles/PMC7878365/
https://europepmc.org/articles/PMC7878365/
Autor:
Amanda James, Myungjin Kim, Shuangcheng Wu, Yatrik M. Shah, Boyoung Kim, Uhn-Soo Cho, Joel K. Greenson, Ian A. Semple, Allison H. Kowalsky, Sim Namkoong, Chun-Seok Cho, Sumeet Solanki, M. A. Tohamy, Bondong Gu, Jun Hee Lee, Sung-Rye Park
Publikováno v:
Cell Discovery, Vol 5, Iss 1, Pp 1-18 (2019)
Cell Discovery
Cell Discovery
mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated
Publikováno v:
Genes
Genes, Vol 11, Iss 896, p 896 (2020)
Genes, Vol 11, Iss 896, p 896 (2020)
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism that integrates environmental inputs, including nutrients, growth factors, and stress signals. mTORC1 activation upregulates anabolism of diverse macromolecules