Výsledky vyhledávání - "Allison Fedolak"

Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration

Autor: Iain M. Wallace, Hyun-Hee Cho, Pramod Pandey, Soo-Hee Park, Allison Fedolak, Dechristopher Brian Addison, Christopher Hogan, Olga Rozhitskaya, Derek Bamford, Liansheng Su, Toshiyuki Honda, Rohit Duvadie, Linh Vong, Elizabeth Tomlinson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:991-994

The relaxin family peptide receptors have been implicated in numerous physiological processes including energy homeostasis, cardiac function, wound healing, and reproductive function. Two family members, RXFP3 and RXFP4, are class A GPCRs with endoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418b6fe5324da9d6735f1f588262d09c
https://doi.org/10.1016/j.bmcl.2019.02.013

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Characterization of Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as Stimulators of Steroidogenesis

Autor: Allison Fedolak, Vassilios Papadopoulos, Irina N. Gaisina, Andrew Midzak, Emily Sabath, Taleen Hanania, Dani Brunner, Hendra Gunosewoyo, Alan P. Kozikowski

Publikováno v: Journal of Medicinal Chemistry. 56:5115-5129

Inhibition of GSK-3β has been well documented to account for the behavioral actions of the mood stabilizer lithium in various animal models of mood disorders. Recent studies have showed that genetic or pharmacological inhibition of GSK-3β resulted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78530b76f7d68cdab6feff909fb3b193
https://doi.org/10.1021/jm400511s

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Synthesis and Biological Evaluation of Novel Hybrids of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists

Autor: Oluseye K. Onajole, Dani Brunner, J. Brek Eaton, Li-Fang Yu, Allison Fedolak, Hendra Gunosewoyo, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski

We previously reported the cyclopropylpyridine and isoxazolylpyridine ether scaffolds to be versatile building blocks for creating potent α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists with excellent selectivity over the α3β4 subt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3a9f05eefcc149a307e2923ae03bd8
https://europepmc.org/articles/PMC5097879/

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Identification of Novel α4β2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity

Autor: Dani Brunner, Barbara J. Caldarone, Allison Fedolak, Ronald J. Lukas, Taleen Hanania, J. Brek Eaton, Werner Tückmantel, Li-Fang Yu, Alan P. Kozikowski

Publikováno v: Journal of Medicinal Chemistry. 55:812-823

There is considerable evidence to support the hypothesis that the blockade of nAChR is responsible for the antidepressant action of nicotinic ligands. The nicotinic acetylcholine receptor (nAChR) antagonist, mecamylamine, has been shown to be an effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ac15778e5639cd1126a8e8147d2cb9
https://doi.org/10.1021/jm201301h

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Discovery of Isoxazole Analogues of Sazetidine-A as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists for the Treatment of Depression

Autor: Katie Cavino, Afshin Ghavami, Barbara J. Caldarone, Jianhua Liu, Allison Fedolak, Li-Fang Yu, Ronald J. Lukas, Christina Ruiz, Alan P. Kozikowski, Matthew Terry, Daguang Wang, David Lowe, Dani Brunner, J. Brek Eaton

Publikováno v: Journal of Medicinal Chemistry. 54:7280-7288

Depression, a common neurological condition, is one of the leading causes of disability and suicide worldwide. Standard treatment, targeting monoamine transporters selective for the neurotransmitters serotonin and noradrenaline, is not able to help m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129de2091cdbfddeda3218b1545813d3
https://doi.org/10.1021/jm200855b

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Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380

Autor: Allison Fedolak, Michael Manzano, Marina R. Picciotto, Afshin Ghavami, Mei Kwan, Berend Olivier, Sheela K. Chellappan, Daguang Wang, Taleen Hanania, Katie Cavino, Neil E. Paterson, Barbara J. Caldarone, Alan P. Kozikowski

Publikováno v: Psychopharmacology. 217:199-210

Nicotinic acetylcholine receptor (nAChR) agonists, partial agonists, and antagonists have antidepressant-like effects in rodents and reduce symptoms of depression in humans.The study determined whether the antidepressant-like effect of the nAChR β2*

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026bd408630f21b187ffcc6cd7018171
https://doi.org/10.1007/s00213-011-2271-y

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Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents

Autor: Berend Olivier, Barbara J. Caldarone, Allison Fedolak, Neil E. Paterson, Taleen Hanania, Afshin Ghavami

Publikováno v: Pharmacology Biochemistry and Behavior. 95:449-456

The present studies assessed the potential abuse liability and likely mechanism(s) of action of the wake-promoting agent modafinil. Methods Experiments assessed the locomotor sensitization (LS) and discriminative stimulus (DS) properties of modafinil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61197420f23d2bb5b67302c3c93a6fce
https://doi.org/10.1016/j.pbb.2010.03.006

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Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II

Autor: Han Kun Zhang, Taleen Hanania, Ronald J. Lukas, J. Brek Eaton, Alan P. Kozikowski, Li-Fang Yu, Allison Fedolak, Dani Brunner

Publikováno v: Journal of medicinal chemistry. 55(22)

In our continued efforts to develop α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists as novel antidepressants having a unique mechanism of action, structure-activity relationship (SAR) exploration of certain isoxazolylpyridine ethers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8798aa190026fe665cd03898be3e3853
https://pubmed.ncbi.nlm.nih.gov/23092294

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Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders

Autor: Irina N. Gaisina, Sylvie Y. Blond, Hongbin Yuan, Alan P. Kozikowski, Barbara J. Caldarone, Allison Fedolak, Pavel A. Petukhov, Paul McGonigle

Publikováno v: Journal of the American Chemical Society. 129(26)

More than two million American adults, or approximately one percent of the population 18 years or older, suffer from bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid. Both are relatively dated d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab994d439697fe39110c4d06e2e1d828
https://pubmed.ncbi.nlm.nih.gov/17552518

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