Výsledky vyhledávání - "Allison Bode"

Akademický článek

OcclusionChip: A functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability

Autor: Yuncheng Man, Ran An, Karamoja Monchamp, Zoe Sekyonda, Erdem Kucukal, Chiara Federici, William J. Wulftange, Utku Goreke, Allison Bode, Vivien A. Sheehan, Umut A. Gurkan

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Red blood cell (RBC) deformability is a valuable hemorheological biomarker that can be used to assess the clinical status and response to therapy of individuals with sickle cell disease (SCD). RBC deformability has been measured by ektacytometry for

Externí odkaz: https://doaj.org/article/addde170f9b44f8283e6b69fa8a481c4

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Membrane bending and sphingomyelinase-associated, sulfatide-dependent hypoxic adhesion of sickle mature erythrocytes

Autor: Utku Goreke, Erdem Kucukal, Fang Wang, Ran An, Nicole Arnold, Erina Quinn, Charlotte Yuan, Allison Bode, Ailis Hill, Yuncheng Man, Bryan C. Hambley, Robert Schilz, Mahazarin Ginwalla, Jane A. Little, Umut A. Gurkan

Publikováno v: Blood Advances. 7:2094-2104

Abnormal erythrocyte adhesion owing to polymerization of sickle hemoglobin is central to the pathophysiology of sickle cell disease (SCD). Mature erythrocytes constitute >80% of all erythrocytes in SCD; however, the relative contributions of erythroc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9f75ab4ae9918d484e2038ce57f28a7
https://doi.org/10.1182/bloodadvances.2022008392

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Sickle red blood cell‐derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor

Autor: Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Chunsheng Chen, Fang Wang, Fuad Abdulla, Erdem Kucukal, William J. Wulftange, Utku Goreke, Allison Bode, Lalitha V. Nayak, Gregory M. Vercellotti, John D. Belcher, Jane A. Little, Umut A. Gurkan

Publikováno v: British Journal of Haematology. 201:552-563

Endothelial activation and sickle red blood cell (RBC) adhesion are central to the pathogenesis of sickle cell disease (SCD). Quantitatively, RBC-derived extracellular vesicles (REVs) are more abundant from SS RBCs compared with healthy RBCs (AA RBCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76657ad8b6769501b0ea35e857d92c2
https://doi.org/10.1111/bjh.18616

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Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Autor: Yuncheng Man, Douglas H. Wu, Ran An, Peiran Wei, Karamoja Monchamp, Utku Goreke, Zoe Sekyonda, William J. Wulftange, Chiara Federici, Allison Bode, Lalitha V. Nayak, Jane A. Little, Umut A. Gurkan

Publikováno v: Sensors & Diagnostics. 2:457-467

A microfluidic assay integrated with capillary network-inspired microcapillary arrays and endothelial-associated protein functionalization enables concurrent assessment of red blood cell adhesion and microcapillary occlusion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46b901b4111a61b81c73ea740627e1b8
https://doi.org/10.1039/d2sd00095d

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Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation

Autor: Utku Goreke, Allison Bode, Sena Yaman, Umut A. Gurkan, Naside Gozde Durmus

Publikováno v: Lab Chip

Single cells have unique biophysical signatures that can rapidly change during various healthy and pathological states. For instance, cellular density is an inherent property differing between cell types. Characterizing dramatic changes in fundamenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44375a7879a88fa856a59a420b1f31cc
https://doi.org/10.1039/d1lc00686j

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Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin

Autor: Utku Goreke, Shamreen Iram, Gundeep Singh, Sergio Domínguez-Medina, Yuncheng Man, Allison Bode, Ran An, Jane A. Little, Christopher L. Wirth, Michael Hinczewski, Umut A. Gurkan

Could the phenomenon of catch bonding—force-strengthened cellular adhesion—play a role in sickle cell disease, where abnormal red blood cell (RBC) adhesion obstructs blood flow? Here we investigate the dynamics of sickle RBCs adhering to a surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b8777921964b41ca4f1bf5d247feca
https://doi.org/10.1101/2022.11.12.515898

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Antithrombin-III mitigates thrombin-mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow

Autor: William J. Wulftange, Erdem Kucukal, Yuncheng Man, Ran An, Karamoja Monchamp, Charlotte D. Sevrain, Himanshu R. Dashora, Amma T. Owusu‐Ansah, Allison Bode, Anton Ilich, Jane A. Little, Nigel S. Key, Umut A. Gurkan

Publikováno v: British journal of haematology. 198(5)

Individuals with sickle cell disease (SCD) have persistently elevated thrombin generation that results in a state of systemic hypercoagulability. Antithrombin-III (ATIII), an endogenous serine protease inhibitor, inhibits several enzymes in the coagu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61627fd0f642859ef61fab98563f7f1
https://pubmed.ncbi.nlm.nih.gov/35822297

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