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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

Autor: Letavic MA; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Savall BM; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Allison BD; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Aluisio L; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Andres JI; Janssen Research & Development, a Division of Janssen-Cilag , Jarama 75, 45007 Toledo, Spain., De Angelis M; Janssen Research & Development, a Division of Janssen-Cilag , Jarama 75, 45007 Toledo, Spain., Ao H; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Beauchamp DA; Janssen Research & Development, LLC , 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bonaventure P; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Bryant S; Janssen Research & Development, LLC , 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Carruthers NI; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Ceusters M; Janssen Research & Development, Janssen Pharmaceutica NV , Turnhoutseweg 30, 2340 Beerse, Belgium., Coe KJ; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Dvorak CA; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Fraser IC; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Gelin CF; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Koudriakova T; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Liang J; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Lord B; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Lovenberg TW; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Otieno MA; Janssen Research & Development, LLC , 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Schoetens F; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Swanson DM; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Wang Q; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Wickenden AD; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States., Bhattacharya A; Janssen Research & Development, LLC , 3210 Merryfield Row, San Diego, California 92121, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Jun 08; Vol. 60 (11), pp. 4559-4572. Date of Electronic Publication: 2017 May 25.

Indole- and benzothiophene-based histamine H3 antagonists.

Autor: Santillan A Jr; Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121-1126, United States., McClure KJ, Allison BD, Lord B, Boggs JD, Morton KL, Everson AM, Nepomuceno D, Letavic MA, Lee-Dutra A, Lovenberg TW, Carruthers NI, Grice CA

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Nov 01; Vol. 20 (21), pp. 6226-30. Date of Electronic Publication: 2010 Aug 27.

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.

Autor: Pippel M; Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA., Allison BD, Phuong VK, Li L, Morton MF, Prendergast C, Wu X, Shankley NP, Rabinowitz MH

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Nov 15; Vol. 19 (22), pp. 6373-5. Date of Electronic Publication: 2009 Sep 23.