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pro vyhledávání: '"Allison B. Haugrud"'
Autor:
Yongxian Zhuang, Joseph D. Coppock, Allison B. Haugrud, John H. Lee, Shanta M. Messerli, W. Keith Miskimins
Publikováno v:
Cancers, Vol 16, Iss 8, p 1525 (2024)
Elevated glucose uptake and production of lactate are common features of cancer cells. Among many tumor-promoting effects, lactate inhibits immune responses and is positively correlated with radioresistance. Dichloroacetate (DCA) is an inhibitor of p
Externí odkaz:
https://doaj.org/article/c3b050f63b3648b4b87e08210e8cc545
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundNicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage. We have previ
Externí odkaz:
https://doaj.org/article/663e5b9f2bb0408797b06fec4439c04e
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108444 (2014)
Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasi
Externí odkaz:
https://doaj.org/article/57739f24aac24d3093bc95ee863cedef
Publikováno v:
Breast Cancer Research and Treatment. 147:539-550
The unique metabolism of breast cancer cells provides interest in exploiting this phenomenon therapeutically. Metformin, a promising breast cancer therapeutic, targets complex I of the electron transport chain leading to an accumulation of reactive o
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108444 (2014)
PLoS ONE
PLoS ONE
Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasi
Publikováno v:
Cancer Research. 73:1869-1869
The unusual metabolism of aerobic glycolysis in cancer cells suggests that this phenomenon can be exploited for improved therapies. Metformin, a drug used to treat type 2 diabetics, has clinical evidence of cancer prevention, and some studies show th