Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Allison M. Martino"'
Autor:
Allison M. Martino, James L Ellis, Irina S. Zemtseva, Roseanne S. Wexler, Joseph D. Schroeder, Steward K Richardson, David R. Janero, L. Gordon Letts, Shiow-Jyi Wey, Madhavi G. Murty, Michael E. Augustyniak, William M. Selig, David S. Garvey, A. Mark Trocha, Brian M. Zifcak, Edward Cochran, Terry L. Melim, Delano V. Young, Xinqin Fang
Publikováno v:
Journal of Medicinal Chemistry. 50:6367-6382
Indomethacin, a nonselective cyclooxygenase (COX) inhibitor, was modified in three distinct regions in an attempt both to increase cyclooxygenase-2 (COX-2) selectivity and to enhance drug safety by covalent attachment of an organic nitrate moiety as
Autor:
Irina S. Zemtseva, Michael E. Augustyniak, Allison M. Martino, Richard A. Earl, Delano V. Young, L. Gordon Letts, Madhavi G. Murty, Matthew J. Shumway, David S. Garvey, David J. Schwalb, Subhash P. Khanapure, Andrzej M. Trocha, David R. Janero
Publikováno v:
Journal of Medicinal Chemistry. 48:3930-3934
Incorporation of a spacer group between the central scaffold and the aryl ring resulted in a new cyclooxygenase-2 (COX-2) selective inhibitor core structure, 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone (20), with COX-2 I
Autor:
Allison M. Martino, Stephen P. Flaherty, David E. Root, Brian P. Kelley, Brent R. Stockwell, Mitchell R. Lunn
Publikováno v:
Chemistry & Biology. 11(11):1495-1503
High-throughput assays generate immense quantities of data that require sophisticated data analysis tools. We have created a freely available software tool, SLIMS (Small Laboratory Information Management System), for chemical genetics which facilitat
Autor:
Jianhua Zhou, Mitchell R. Lunn, Nguyen thi Man, Brent R. Stockwell, David E. Root, Glenn E. Morris, Elliot J. Androphy, Daniel D. Coovert, Charlotte J. Sumner, Arthur H.M. Burghes, Brian P. Kelley, Allison M. Martino, Stephen P. Flaherty
Publikováno v:
Chemistry & Biology. 11:1489-1493
Most patients with the pediatric neurodegenerative disease spinal muscular atrophy have a homozygous deletion of the survival motor neuron 1 ( SMN1 ) gene, but retain one or more copies of the closely related SMN2 gene. The SMN2 gene encodes the same
Autor:
David R. Janero, Ramani R. Ranatunge, Matthew J. Shumway, Delano V. Young, James L. Ellis, Joseph D. Schroeder, S. William Tam, David S. Garvey, A. Mark Trocha, L. Gordon Letts, Madhavi G. Murty, Michael E. Augustyniak, Richard A. Earl, Upul K. Bandarage, Allison M. Martino, Stewart K. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 47:2180-2193
The synthesis of a series of novel pyrazoles containing a nitrate (ONO(2)) moiety as a nitric oxide (NO)-donor functionality is reported. Their COX-1 and COX-2 inhibitory activities in human whole blood are profiled. Our data demonstrate that pyrazol
Autor:
L. Gordon Letts, Delano V. Young, Madhavi G. Murty, Stewart K. Richardson, Ramani R. Ranatunge, Allison M. Martino, David R. Janero, David S. Garvey, Irina S. Zemetseva
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1357-1366
Novel series of pyrazolo[5,1- b ]1,3-oxazolidines, pyrazolo[5,1- b ]1,3-oxazines and imidazolidino[1,2- d ]pyrazoles were synthesized. These compounds were evaluated in vitro for their ability to inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2
Autor:
Przemyslaw A. Marek, S. William Tam, Madhavi G. Murty, Maiko Ezawa, Mark Trocha, L. Gordon Letts, Richard A Earl, Rick D Gaston, Delano V. Young, Subhash P. Khanapure, Xinqin Fang, David S. Garvey, David R. Janero, Allison M. Martino, Matthew J. Shumway
Publikováno v:
Journal of medicinal chemistry. 46(25)
A novel series of benzo-1,3-dioxolane metharyl derivatives was synthesized and evaluated for cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) inhibition in human whole blood (HWB). In the present study, structure-activity relationships (SAR) in
Autor:
Shiow-Jyi Wey, Michael E. Augustyniak, Edward D. Cochran, James L. Ellis, Xinqin Fang, David S. Garvey, David R. Janero, L. Gordon Letts, Allison M. Martino, Terry L. Melim, Madhavi G. Murty, Steward K. Richardson, Joseph D. Schroeder, William M. Selig, A. Mark Trocha, Roseanne S. Wexler, Delano V. Young, Irina S. Zemtseva, Brian M. Zifcak
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 25, p6367-6382, 16p