Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Allie H Grossmann"'
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Akademický článek
Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy
Autor: Yinshen Wee, Junhua Wang, Emily C. Wilson, Coulson P. Rich, Aaron Rogers, Zongzhong Tong, Evelyn DeGroot, Y. N. Vashisht Gopal, Michael A. Davies, H. Atakan Ekiz, Joshua K. H. Tay, Chris Stubben, Kenneth M. Boucher, Juan M. Oviedo, Keke C. Fairfax, Matthew A. Williams, Sheri L. Holmen, Roger K. Wolff, Allie H. Grossmann
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While it is clear that cancer cells can have the capacity to alter immune landscapes, ou
Externí odkaz: https://doaj.org/article/e7e3f29dc417478dac14dd2ee69fe482
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Figure S4 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State
Autor: Allie H. Grossmann, Sheri L. Holmen, Dean Y. Li, Shannon J. Odelberg, Andrea Bild, David A. Kircher, Coulson P. Rich, Donghan Shin, Tara Mleynek, Roger K. Wolff, Lise K. Sorensen, Jingfu Peng, Aaron Rogers, Lehi Acosta-Alvarez, Samuel W. Brady, Jae Hyuk Yoo
Figure S4. Primary tumor incidence, growth, survival and metastasis in Ptenf/f vs. Arf6Q67L mice. (a) Increased tumor incidence (% = # of mice that developed a tumor / # TVA positive, injected mice) in Ptenf/f vs. Arf6Q67L cohorts. Fisher's exact tes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def0b48b2cc83022bfecdb8248f0a63
https://doi.org/10.1158/0008-5472.22420623
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Data from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State
Autor: Allie H. Grossmann, Sheri L. Holmen, Dean Y. Li, Shannon J. Odelberg, Andrea Bild, David A. Kircher, Coulson P. Rich, Donghan Shin, Tara Mleynek, Roger K. Wolff, Lise K. Sorensen, Jingfu Peng, Aaron Rogers, Lehi Acosta-Alvarez, Samuel W. Brady, Jae Hyuk Yoo
Melanoma has an unusual capacity to spread in early-stage disease, prompting aggressive clinical intervention in very thin primary tumors. Despite these proactive efforts, patients with low-risk, low-stage disease can still develop metastasis, indica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfbd622d715707efdee9a96edeca39d
https://doi.org/10.1158/0008-5472.c.6510696
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7
Akademický článek
AKT1 Activation Promotes Development of Melanoma Metastases
Autor: Joseph H. Cho, James P. Robinson, Rowan A. Arave, William J. Burnett, David A. Kircher, Guo Chen, Michael A. Davies, Allie H. Grossmann, Matthew W. VanBrocklin, Martin McMahon, Sheri L. Holmen
Publikováno v: Cell Reports, Vol 13, Iss 5, Pp 898-905 (2015)
Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT signaling in human melanoma metastases led us to evaluate the effect of activated AKT1 expression in non-metastatic BRAFV600E/Cdkn2aNull mouse mel
Externí odkaz: https://doaj.org/article/4e2c49c5716c454581ddfb0df503505a
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8
Abstract B50: Discovery of multiple mechanisms of immune evasion that accelerate primary melanomagenesis in a genetic model with low tumor mutation burden
Autor: Emily C Wilson, Yinshen Wee, Junhua Wang, Coulson P Rich, Aaron Rogers, Roger K Wolff, Sheri L Holmen, Allie H Grossmann
Publikováno v: Cancer Immunology Research. 10:B50-B50
Although immune checkpoint blockade (ICB) therapy can improve outcomes in advanced melanoma, early detection and treatment focused on preventing metastasis remain the optimal approaches for superior survival. Immune evasion occurs early in melanoma d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43154292d546b6fe77e21f44aaa1432d
https://doi.org/10.1158/2326-6074.tumimm22-b50
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The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State
Autor: Jae Hyuk Yoo, Andrea H. Bild, Lehi Acosta-Alvarez, Dean Y. Li, Aaron Rogers, Samuel W. Brady, Roger K. Wolff, Sheri L. Holmen, Shannon J. Odelberg, David A. Kircher, Lise K. Sorensen, Jingfu Peng, Tara M. Mleynek, Donghan Shin, Allie H. Grossmann, Coulson P. Rich
Publikováno v: Cancer Res
Melanoma has an unusual capacity to spread in early-stage disease, prompting aggressive clinical intervention in very thin primary tumors. Despite these proactive efforts, patients with low-risk, low-stage disease can still develop metastasis, indica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d50d4f6e091b7a841698546e83f00e
https://doi.org/10.1158/0008-5472.can-18-3026
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