Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Allert J, Jonker"'
Autor:
Yasmine Y. Fathy, Laura E. Jonkman, John J. Bol, Evelien Timmermans, Allert J. Jonker, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-19 (2022)
Abstract Background Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Axonal degeneration occurs early, preceedi
Externí odkaz:
https://doaj.org/article/b5802d67641a4cab84f753bddba4a79c
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.
Externí odkaz:
https://doaj.org/article/b648848b74c14840be9be48f8be10660
Autor:
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotran
Externí odkaz:
https://doaj.org/article/59339fd0ec524e8d8a59a8fece53b4cb
Autor:
Hung Tri Tran, Esther H. R. Tsai, Amanda J. Lewis, Tim Moors, J. G. J. M. Bol, Iman Rostami, Ana Diaz, Allert J. Jonker, Manuel Guizar-Sicairos, Joerg Raabe, Henning Stahlberg, Wilma D. J. van de Berg, Mirko Holler, Sarah H. Shahmoradian
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Gaining insight to pathologically relevant processes in continuous volumes of unstained brain tissue is important for a better understanding of neurological diseases. Many pathological processes in neurodegenerative disorders affect myelinated axons,
Externí odkaz:
https://doaj.org/article/1d7ffb31c60142db90c6cd2a80d72906
Autor:
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a04239147e064305a9366bd3092f352a
Autor:
Yasmine Y. Fathy, Laura E. Jonkman, John J. Bol, Evelien Timmermans, Allert J. Jonker, Annemieke J.M. Rozemuller, Wilma DJ van de Berg
Background Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). Axonal degeneration occurs early, preceeding and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e78f682a9e297e9687d55795182d3ad
https://doi.org/10.21203/rs.3.rs-1767866/v1
https://doi.org/10.21203/rs.3.rs-1767866/v1
Autor:
Tim S. Heistek, Natalia A. Goriounova, Ouissame Mnie-Filali, Wilma D.J. van den Berg, Huub Terra, Tommy Pattij, Christiaan P. J. de Kock, Roel de Haan, Joshua Obermayer, Sybren F. de Kloet, Christian Kortleven, Antonio Luchicchi, Anna A. Galakhova, Ayoub J. Khalil, Bastiaan Bruinsma, Allert J. Jonker, Huibert D. Mansvelder, Tim Kroon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Obermayer, J, Luchicchi, A, Heistek, T S, de Kloet, S F, Terra, H, Bruinsma, B, Mnie-Filali, O, Kortleven, C, Galakhova, A A, Khalil, A J, Kroon, T, Jonker, A J, de Haan, R, van den Berg, W D J, Goriounova, N A, de Kock, C P J, Pattij, T & Mansvelder, H D 2019, ' Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention ', Nature Communications, vol. 10, no. 1, pp. 5280 . https://doi.org/10.1038/s41467-019-13244-9
Nature Communications
Obermayer, J, Luchicchi, A, Heistek, T S, de Kloet, S F, Terra, H, Bruinsma, B, Mnie-Filali, O, Kortleven, C, Galakhova, A A, Khalil, A J, Kroon, T, Jonker, A J, de Haan, R, van den Berg, W D J, Goriounova, N A, de Kock, C P J, Pattij, T & Mansvelder, H D 2019, ' Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention ', Nature Communications, vol. 10, no. 1, 5280 . https://doi.org/10.1038/s41467-019-13244-9
Nature Communications, 10(1):5280. Nature Publishing Group
Nature Communications, 10(1). Nature Publishing Group
Obermayer, J, Luchicchi, A, Heistek, T S, de Kloet, S F, Terra, H, Bruinsma, B, Mnie-Filali, O, Kortleven, C, Galakhova, A A, Khalil, A J, Kroon, T, Jonker, A J, de Haan, R, van den Berg, W D J, Goriounova, N A, de Kock, C P J, Pattij, T & Mansvelder, H D 2019, ' Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention ', Nature Communications, vol. 10, no. 1, pp. 5280 . https://doi.org/10.1038/s41467-019-13244-9
Nature Communications
Obermayer, J, Luchicchi, A, Heistek, T S, de Kloet, S F, Terra, H, Bruinsma, B, Mnie-Filali, O, Kortleven, C, Galakhova, A A, Khalil, A J, Kroon, T, Jonker, A J, de Haan, R, van den Berg, W D J, Goriounova, N A, de Kock, C P J, Pattij, T & Mansvelder, H D 2019, ' Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention ', Nature Communications, vol. 10, no. 1, 5280 . https://doi.org/10.1038/s41467-019-13244-9
Nature Communications, 10(1):5280. Nature Publishing Group
Nature Communications, 10(1). Nature Publishing Group
Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite neighbo
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, 13(1):4819. Nature Publishing Group UK
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we ana
Autor:
Remco Natté, Wilma D.J. van de Berg, Marko Popovic, Allert J. Jonker, Jochen Walter, Jeroen J.M. Hoozemans, Annemieke J.M. Rozemuller, Femke H. Bouwman, Louise van der Weerd, Sathish Kumar, Baayla D.C. Boon, Marjolein Bulk
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Xiaoyue Zhu, William E. Van Nostrand, Henne Holstege, Wilma D.J. van de Berg, Allert J. Jonker, Annemieke J.M. Rozemuller, Louise van der Weerd, Sathish Kumar, Baayla D.C. Boon, Jeroen J. M. Hoozemans, Tjado H. J. Morrema, Femke H. Bouwman, Emma van den Berg, Sven J. van der Lee, Remco Natté, Marjolein Bulk, Marko Popovic, Jochen Walter
Publikováno v:
Acta Neuropathologica, 140, 811-830. SPRINGER
Boon, B D C, Bulk, M, Jonker, A J, Morrema, T H J, van den Berg, E, Popovic, M, Walter, J, Kumar, S, van der Lee, S J, Holstege, H, Zhu, X, van Nostrand, W E, Natté, R, van der Weerd, L, Bouwman, F H, van de Berg, W D J, Rozemuller, A J M & Hoozemans, J J M 2020, ' The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease ', Acta Neuropathologica, vol. 140, no. 6, pp. 811-830 . https://doi.org/10.1007/s00401-020-02198-8
Acta Neuropathologica
Acta Neuropathologica, 140(6), 811-830. Springer Verlag
Boon, B D C, Bulk, M, Jonker, A J, Morrema, T H J, van den Berg, E, Popovic, M, Walter, J, Kumar, S, van der Lee, S J, Holstege, H, Zhu, X, van Nostrand, W E, Natté, R, van der Weerd, L, Bouwman, F H, van de Berg, W D J, Rozemuller, A J M & Hoozemans, J J M 2020, ' The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease ', Acta Neuropathologica, vol. 140, no. 6, pp. 811-830 . https://doi.org/10.1007/s00401-020-02198-8
Acta Neuropathologica
Acta Neuropathologica, 140(6), 811-830. Springer Verlag
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance. Previously, we observed an atypical Aβ deposit, referred to as the coarse-grained plaque. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005fdf91e6738fdcd8a9a8d87efb5600
http://hdl.handle.net/1887/3181998
http://hdl.handle.net/1887/3181998