Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Allen W. Harrison"'
Autor:
W. J. Howe, W. T. Lowther, J. O. Hui, W. G. Tarpley, D. E. Emmert, Chetana Rao, A G Tomasselli, John H. Kinner, V. S. Bradford, D. L. Alexander, Tomi K. Sawyer, B.M. Dunna, Robert A. Conradi, D. L. Decamp, Clark W. Smith, Allen W. Harrison, Charles S. Craik, James Michael Tustin, T. J. Mcquade, Robert L. Heinrikson, Y. Z. Zhang, Philip S. Burton, Jed F. Fisher, Roger A. Poorman, Joseph B. Moon, Jackson B. Hester, D J Staples, L. Liu, P. E. Scarborough, Maggiora Linda Louise
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:819-824
The structure-activity relationships and pharmacophore modeling aspects of a series of HIV PR inhibitors modified at the N- and/or C-terminus of the dipeptide isostere ChaΨ[CH(OH)CH2]Val (Cha, cyclohexylalanine) are reported. The HIV PR binding affi
Autor:
W. J. Howe, W. T. Lowther, A G Tomasselli, D. E. Emmert, D J Staples, Jackson B. Hester, W. G. Tarpley, J. O. Hui, Ben M. Dunn, John H. Kinner, Robert L. Heinrikson, Y. Z. Zhang, Tomi K. Sawyer, Charles S. Craik, D. L. Decamp, James Michael Tustin, T. J. Mcquade, D. L. Alexander, Allen W. Harrison, P. E. Scarborough, Robert A. Conradi, Jed F. Fisher, Roger A. Poorman, Philip S. Burton, Maggiora Linda Louise, V. S. Bradford, Joseph B. Moon, L. Liu, Clark W. Smith, Chetana Rao
Publikováno v:
ChemInform. 26
Autor:
Gordon L. Bundy, Bob D. Rush, Mary J. Ruwart, Jed F. Fisher, Allen W. Harrison, Karen F. Wilkinson
Publikováno v:
Journal of Medicinal Chemistry. 34:3140-3143
Autor:
David M. Guido, Donald T. Pals, Sally J. Couch, Allen W. Harrison, Garry L. Degraaf, Judy A. Lawson, John Rogers, Dorothy M. Sutter, Mark V. Williams, Jed F. Fisher
Publikováno v:
Bioorganicmedicinal chemistry. 2(12)
Among the limitations to the practical therapeutic oligopeptide are low oral availability, indifferent aqueous solubility, and an astonishing efficient sequestration and biliary elimination by a multi-capacity liver transporter. Given the purposed us
Autor:
Allen W. Harrison, Dong-Chool Kim, Jed F. Fisher, Ronald T. Borchardt, Ismael J. Hidalgo, Karen F. Wilkinson, Mary J. Ruwart
Publikováno v:
Journal of drug targeting. 1(4)
To evaluate the bile acid transporter as a means of enhancing the ability of renin-inhibitory peptides (RIPs) to penetrate the intestinal mucosa, two RIP-cholic acid conjugates and an RIP-taurocholic acid conjugate were synthesized. Conjugation was t
Publikováno v:
The Journal of Organic Chemistry. 49:438-442
Publikováno v:
Tetrahedron Letters. 25:3955-3958
Short syntheses of the extremely potent benzopyran prostacyclin mimics 26 and 27 are described using a novel intramolecular Mitsunobu reaction (e.g. 20 → 22) in the key step. This mild cyclization method was also applied to the synthesis of some si
Publikováno v:
Journal of the American Chemical Society. 107:7967-7974
Autor:
Allen W. Harrison, Paul A. Aristoff
Publikováno v:
Tetrahedron Letters. 23:2067-2070
The phenols 13 , 16 , and 21 , produced with remarkable regioselectivity by the cyclization of compounds 10 and 12 , have been converted to the benzindene prostaglandin analogs 25 , 20 , and 24 , respectively. Compounds 24 and 25 are potent prostacyc
Publikováno v:
The Journal of Organic Chemistry. 48:5341-5348
On prepare une serie d'analogues de la carbacycline substitues en 9. L'etape cle est l'addition catalysee par le nickel de l'aluminate d'alcynyle convenable avec la bicyclo [3.3.0] octene-1one-3