Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Allen W Cheever"'
Autor:
Kevin M Vannella, Luke Barron, Lee A Borthwick, Kristen N Kindrachuk, Prakash Babu Narasimhan, Kevin M Hart, Robert W Thompson, Sandra White, Allen W Cheever, Thirumalai R Ramalingam, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004372 (2014)
Mice expressing a Cre recombinase from the lysozyme M-encoding locus (Lyz2) have been widely used to dissect gene function in macrophages and neutrophils. Here, we show that while naïve resident tissue macrophages from IL-4Rαf(lox/delta)LysM(Cre) m
Externí odkaz:
https://doaj.org/article/f6ebeffb5bf74f55ad6766d2236a5225
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 93, Pp 25-32 (1998)
Schistosoma mansoni infections are associated with a strong Th2 cytokine response. Treatment of mice with IL-12 or anti-IL-2 or anti-IL-4 before i.v. injection of eggs increased IFN-gamma production and downregulated Th2 responses and pulmonary granu
Externí odkaz:
https://doaj.org/article/89bace0dbfa645c291738743abf203a1
Autor:
Antonio Gigliotti Rothfuchs, Ester Roffê, Amanda Gibson, Allen W Cheever, R Alan B Ezekowitz, Kazue Takahashi, Mario Steindel, Alan Sher, André Báfica
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e47835 (2012)
Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense. Although recent genetic studies suggest an involvement of MBL/MASP2-associated pathways in Chagas' disease, it is currently unknown whether MBL plays a
Externí odkaz:
https://doaj.org/article/8f0a5115bd3d488586245afbc23cc37e
Publikováno v:
PLoS Pathogens, Vol 7, Iss 8, p e1002171 (2011)
Despite effective chemotherapy to treat schistosome infections, re-infection rates are extremely high. Resistance to reinfection can develop, however it typically takes several years following numerous rounds of treatment and re-infection, and often
Externí odkaz:
https://doaj.org/article/9053d5f2037340eaa4ba0f256bb8350e
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 81-85 (1992)
Cytokines are important in the cell-mediated response to Schistosoma mansoni eggs. We have found that Th2 cytokine responses (e.G. IL-4 and IL-5) are argumented after egg laying begins while the response (IL-2 and IFN-*) are down regulated in S. mans
Externí odkaz:
https://doaj.org/article/c0d26d9b804241edbf483ca29b71843c
Autor:
Allen W. Cheever
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 337-340 (1992)
In this paper a discussin is made on the pathogenesis of schistosomiasis mansoni in mice, presented from the perspectives of "processes", "mediators", "strategies for study" and vasculitis are discussed. The role of mediators, including cells, antibo
Externí odkaz:
https://doaj.org/article/79ff8de5fce24b78ba6e8e829224061b
Autor:
John T Pesce, Thirumalai R Ramalingam, Margaret M Mentink-Kane, Mark S Wilson, Karim C El Kasmi, Amber M Smith, Robert W Thompson, Allen W Cheever, Peter J Murray, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000371 (2009)
Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production. Here, however, we show that macrophage-specific Arg1 functions as a
Externí odkaz:
https://doaj.org/article/9f58dce111ec448b822c1fe1f4d33651
Autor:
John T Pesce, Thirumalai R Ramalingam, Mark S Wilson, Margaret M Mentink-Kane, Robert W Thompson, Allen W Cheever, Joseph F Urban, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000393 (2009)
Retnla (Resistin-like molecule alpha/FIZZ1) is induced during Th2 cytokine immune responses. However, the role of Retnla in Th2-type immunity is unknown. Here, using Retnla(-/-) mice and three distinct helminth models, we show that Retnla functions a
Externí odkaz:
https://doaj.org/article/2421bca13ec8421da25ecd9eb184c829
Autor:
Robert W Thompson, John T Pesce, Thirumalai Ramalingam, Mark S Wilson, Sandy White, Allen W Cheever, Stacy M Ricklefs, Stephen F Porcella, Lili Li, Lesley G Ellies, Thomas A Wynn
Publikováno v:
PLoS Pathogens, Vol 4, Iss 3, p e1000023 (2008)
Cationic amino acid transporters (CAT) are important regulators of NOS2 and ARG1 activity because they regulate L-arginine availability. However, their role in the development of Th1/Th2 effector functions following infection has not been investigate
Externí odkaz:
https://doaj.org/article/c2010fd7023f4d37807348b4daa87aa2
Autor:
Richard L. Gieseck, Thomas H. Acciani, Allen W. Cheever, Thirumalai R. Ramalingam, Thomas A. Wynn, Kevin M. Vannella, Kevin M. Hart, Margaret M. Mentink-Kane
Publikováno v:
The Journal of Pathology. 239:344-354
Persistent or dysregulated IL-13 responses are key drivers of fibrosis in multiple organ systems, and this identifies this cytokine as an important therapeutic target. Nevertheless, the mechanisms by which IL-13 blockade leads to the amelioration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a72127d2b42a60f8eea1737c0e1e5da
https://doi.org/10.1002/path.4733
https://doi.org/10.1002/path.4733