Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Allen Vinegar"'
1
Cardiac Sensitization Testing of the Halon Replacement Candidates Trifluoroiodomethane (Cf3I) and 1,1,2,2,3,3,3-Heptafluoror-1-Iodopropane (C3F7I)
Autor: Allen Vinegar, Darol E. Dodd
Publikováno v: Drug and Chemical Toxicology. 21:137-149
Trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I) have been considered as replacement candidates for halon fire suppressants due to their excellent fire extinguishant capabilities and low ozone depletion potential compar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75a6abdb26a015006ba8d42a9d58766
https://doi.org/10.3109/01480549809011643
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2
Cardiac Sensitization Thresholds of Halon Replacement Chemicals Predicted in Humans by Physiologically-Based Pharmacokinetic Modeling
Autor: Gary W. Jepson, Allen Vinegar
Publikováno v: Risk Analysis. 16:571-579
Human exposure to halons and halon replacement chemicals is often regulated on the basis of cardiac sensitization potential. The dose-response data obtained from animal testing are used to determine the no observable adverse effect level (NOAEL) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecaea0a74ad6f0c4afcd6611008aa0cb
https://doi.org/10.1111/j.1539-6924.1996.tb01102.x
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3
Hepatotoxicity in Guinea Pigs Following Acute Inhalation Exposure to 1,1-Dichloro-2,2,2-Trifluoroethane
Autor: Darol E. Dodd, Marilyn E. George, Allen Vinegar, Gary B. Marit
Publikováno v: Toxicologic Pathology. 22:404-414
Groups of 10 male Hartley guinea pigs were exposed to 3.0, 2.0, 1.0, or 0.1% (v/v) 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123) or 1.0% (v/v) halothane by inhalation for 4 hr. A sixth group of 10 guinea pigs received only air. All animals were sacri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11e161e7f0959c03d5e0dabaff8d631
https://doi.org/10.1177/019262339402200406
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4
Polychlorotrifluoroethylene (PCTFE) oligomer pharmacokinetics in Fischer 344 rats: Development of a physiologically based model*1, *2
Autor: Edwin R. Kinkead, Melvin E. Andersen, Daniel L. Pollard, Connie S. Seckel, Allen Vinegar, Rory B. Conolly
Publikováno v: Fundamental and Applied Toxicology. 18:504-514
The hydraulic fluid oil polychlorotrifluoroethylene (PCTFE) is hepato- and nephrotoxic in the rat. Male Fischer 344 rats were exposed to PCTFE either for a single 6-hr exposure (0.5 or 0.25 mg/liter) or daily 5 days/week, 6 hr/day, for 13 weeks (0.5,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a306bd8c418dda7b1d011d45e1b3614b
https://doi.org/10.1016/0272-0590(92)90109-u
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6
Physiologically Based Pharmacokinetic Model of the Metabolism of Trichloroethylene by an Isolated Ventilated Perfused Lung
Autor: K. L. Auten, Rory B. Conolly, Allen Vinegar, C. S. Seckel, Y. M. Reed
Publikováno v: Inhalation Toxicology. 2:285-294
Biotransformation is often a determinant of pharmacokinetic behavior and toxicity. While the liver is usually the quantitatively most significant site, metabolism in other tissues may cause nonhepatic toxicity and also may affect the pharmacokinetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03639736a00b5349c1ef609b87a55d5c
https://doi.org/10.3109/08958379009145259
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7
Use of a Physiologically Based Pharmacokinetic Model and Computer Simulation for Retrospective Assessment of Exposure to Volatile Toxicants
Autor: Melvin E. Andersen, Darrell W. Winsett, Allen Vinegar, Rory B. Conolly
Publikováno v: Inhalation Toxicology. 2:119-128
Personal protective equipment often is used to prevent exposure to volatile toxicants. The effectiveness of such equipment can be evaluated by (1) measuring the postexpo-sure concentration of toxicant in expired breath and (2) using a physiologically
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::300f48011bb70c1426cdc1d952746b4c
https://doi.org/10.3109/08958379009145249
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8
Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: a corollary approach to physiologically based pharmacokinetic modeling
Autor: J. N. Mcdougal, Jeffrey W. Fisher, Annie M. Jarabek, R. J. Williams, Allen Vinegar
Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 30(1)
The goal of this study was to develop a human physiologically based pharmacokinetic (PBPK) model for the chemical HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and its major metabolite, trifluoroacetic acid (TFA). No human kinetic data for HCFC-123 a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f875c5ded3e1b134714e663a48582f72
https://pubmed.ncbi.nlm.nih.gov/8812223
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9
Mechanistic insights aid the search for CFC substitutes: risk assessment of HCFC-123 as an example
Autor: R. Joel Williams, Reva Rubenstein, Annie M. Jarabek, Jeffrey W. Fisher, James N. McDougal, Allen Vinegar, John C. Lipscomb
Publikováno v: Risk analysis : an official publication of the Society for Risk Analysis. 14(3)
An international consensus on the need to reduce the use of chlorofluorocarbons (CFCs) and other ozone-depleting gases such as the halons led to the adoptions of the 1987 Montreal Protocol and Title VI of the 1990 Clean Air Act Amendments, “Protect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ef098da712e7514c5edc04a51ba690
https://pubmed.ncbi.nlm.nih.gov/8029495
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