Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Allen R. Buskirk"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Translation elongation is essential for maintaining cellular proteostasis, and alterations in the translational landscape are associated with a range of diseases. Ribosome profiling allows detailed measurements of translation at the genome s
Externí odkaz:
https://doaj.org/article/4a19ce39273348e8a8e77454bb363d00
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Small proteins consisting of 50 or fewer amino acids have been identified as regulators of larger proteins in bacteria and eukaryotes. Despite the importance of these molecules, the total number of small proteins remains unknown because conv
Externí odkaz:
https://doaj.org/article/01f8e0e61cfc4284a906889e9ea5bfc7
Publikováno v:
Cell Reports, Vol 14, Iss 4, Pp 686-694 (2016)
The rate of protein synthesis varies according to the mRNA sequence in ways that affect gene expression. Global analysis of translational pausing is now possible with ribosome profiling. Here, we revisit an earlier report that Shine-Dalgarno sequence
Externí odkaz:
https://doaj.org/article/223274cd3c7547c0867397ade3c3d301
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 13-21 (2015)
Ribosome profiling is a powerful method for globally assessing the activity of ribosomes in a cell. Despite its application in many organisms, ribosome profiling studies in bacteria have struggled to obtain the resolution necessary to precisely defin
Externí odkaz:
https://doaj.org/article/ecb7728168d248dc9a6ccf1c7c222dd3
Autor:
Mickey R. Miller, Allen R. Buskirk
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
In bacteria, transfer-messenger RNA (tmRNA) and SmpB comprise the most common and effective system for rescuing stalled ribosomes. Ribosomes stall on mRNA transcripts lacking stop codons and are rescued as the defective mRNA is swapped for the tmRNA
Externí odkaz:
https://doaj.org/article/4be75364e5f846a88c4851ec49eb51dc
Translation elongation is essential for maintaining cellular proteostasis, and alterations in the translational landscape are associated with a range of diseases. Ribosome profiling allows detailed measurement of translation at genome scale. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f484753f032f5bf7a48d5843b63a1c63
https://doi.org/10.1101/2023.04.24.538053
https://doi.org/10.1101/2023.04.24.538053
Autor:
Heather A. Feaga, Hye-Rim Hong, Cassidy R. Prince, Ananda Rankin, Allen R. Buskirk, Jonathan Dworkin
Publikováno v:
Journal of Bacteriology. 205
Elongation factor P (EF-P) is a universally conserved translation factor that prevents ribosome stalling at amino acids that form peptide bonds with low efficiency, particularly polyproline tracts. Phenotypes associated with EF-P deletion are pleiotr
Autor:
Kazuki Saito, Hanna Kratzat, Annabelle Campbell, Robert Buschauer, A. Maxwell Burroughs, Otto Berninghausen, L. Aravind, Rachel Green, Roland Beckmann, Allen R. Buskirk
Publikováno v:
Nature
Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and aborted proteins for degradation(1,2). In bacteria, it remains unclear how rescue pathways distinguish ribosomes stalled in the middle of a transcript from actively t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f568c9a4e943a00561abb013ef6c1a
https://europepmc.org/articles/PMC8934283/
https://europepmc.org/articles/PMC8934283/
Publikováno v:
J Bacteriol
Small proteins encoded by open reading frames (ORFs) shorter than 50 codons (small ORFs [sORFs]) are often overlooked by annotation engines and are difficult to characterize using traditional biochemical techniques. Ribosome profiling has tremendous
Autor:
Annabelle Campbell, Hanna Kratzat, Kazuki Saito, Robert Buschauer, Roland Beckmann, L. Aravind, Allen R. Buskirk, Rachel Green, Otto Berninghausen, A. Maxwell Burroughs
Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and aborted proteins for degradation. In bacteria, it remains unclear how rescue pathways distinguish ribosomes stalled in the middle of a transcript from actively transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52c2824bd7d5631c300a56042e401fad
https://doi.org/10.1101/2021.08.16.456513
https://doi.org/10.1101/2021.08.16.456513