Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Allen J, York"'
Autor:
Michael J. Bround, Eaman Abay, Jiuzhou Huo, Julian R. Havens, Allen J. York, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitoc
Externí odkaz:
https://doaj.org/article/112e99cf4854424d83eb6c5e44822e53
Autor:
Stephanie L. K. Bowers, Qinghang Meng, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
Publikováno v:
Cells, Vol 12, Iss 17, p 2174 (2023)
Rationale: The adult cardiac extracellular matrix (ECM) is largely comprised of type I collagen. In addition to serving as the primary structural support component of the cardiac ECM, type I collagen also provides an organizational platform for other
Externí odkaz:
https://doaj.org/article/bc1cebba95e0499bb087b9d6cd86552f
Autor:
Yuhua Wang, Ram Naresh Pandey, Allen J. York, Jaya Mallela, William C. Nichols, Yueh-Chiang Hu, Jeffery D. Molkentin, Kathryn A. Wikenheiser-Brokamp, Rashmi S. Hegde
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Survival and proliferation of vascular cells in the presence of DNA damage is a characteristic of pulmonary arterial hypertension. Here the authors show that the phosphatase EYA3 contributes to vascular remodeling by promoting survival of damaged cel
Externí odkaz:
https://doaj.org/article/a22dbf3a31634184aa871160e2f3a493
Autor:
Greg Davis, Allen J York, Willis Clark Bacon, Suh-Chin Lin, Monica Malone McNeal, Alexander E Yarawsky, Joseph J Maciag, Jeanette L C Miller, Kathryn C S Locker, Michelle Bailey, Rebecca Stone, Michael Hall, Judith Gonzalez, Alyssa Sproles, E Steve Woodle, Kristen Safier, Kristine A Justus, Paul Spearman, Russell E Ware, Jose A Cancelas, Michael B Jordan, Andrew B Herr, David A Hildeman, Jeffery D Molkentin
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254667 (2021)
The world is currently in a pandemic of COVID-19 (Coronavirus disease-2019) caused by a novel positive-sense, single-stranded RNA β-coronavirus referred to as SARS-CoV-2. Here we investigated rates of SARS-CoV-2 infection in the greater Cincinnati,
Externí odkaz:
https://doaj.org/article/567754193c2d4608b6803f79e3e2b6ff
Autor:
Yasuhide Kuwabara, Allen J. York, Suh-Chin Lin, Michelle A. Sargent, Kelly M. Grimes, James P. Pirruccello, Jeffery D. Molkentin
Publikováno v:
Proceedings of the National Academy of Sciences. 120
To better understand the genetic basis of heart disease, we identified a variant in the Flightless-I homolog ( FLII ) gene that generates a R1243H missense change and predisposes to cardiac remodeling across multiple previous human genome-wide associ
Autor:
Robert N. Correll, Jeffrey M. Lynch, Tobias G. Schips, Vikram Prasad, Allen J. York, Michelle A. Sargent, Didier X. P. Brochet, Jianjie Ma, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Transverse tubules (t-tubules) are uniquely-adapted membrane invaginations in cardiac myocytes that facilitate the synchronous release of Ca2+ from internal stores and subsequent myofilament contraction, although these structures become diso
Externí odkaz:
https://doaj.org/article/e0793bad17014a878298a6f75b5f43f6
Autor:
Jennifer Q. Kwong, Xiyuan Lu, Robert N. Correll, Jennifer A. Schwanekamp, Ronald J. Vagnozzi, Michelle A. Sargent, Allen J. York, Jianyi Zhang, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 15-22 (2015)
In the heart, augmented Ca2+ fluxing drives contractility and ATP generation through mitochondrial Ca2+ loading. Pathologic mitochondrial Ca2+ overload with ischemic injury triggers mitochondrial permeability transition pore (MPTP) opening and cardio
Externí odkaz:
https://doaj.org/article/24c55190390241b081190447c3450bdc
Autor:
Jennifer A Schwanekamp, Angela Lorts, Michelle A Sargent, Allen J York, Kelly M Grimes, Demetria M Fischesser, Jason J Gokey, Jeffrey A Whitsett, Simon J Conway, Jeffery D Molkentin
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181945 (2017)
Extracellular matrix production and accumulation stabilize the heart under normal conditions as well as form a protective scar after myocardial infarction injury, although excessive extracellular matrix accumulation with long-standing heart disease i
Externí odkaz:
https://doaj.org/article/9cc0cedc907a4af3b2bf73a1af0b1e12
Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagen
Autor:
Qinghang Meng, Stephanie L. K. Bowers, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
RationaleCardiomyocytes and fibroblasts in the heart communicate through both secreted growth factors as well as through sensing the structural properties of the extracellular matrix that each helps generate. Previous studies have shown that defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27790df13357df1234b902ad0d4ec8f
https://doi.org/10.1101/2022.05.25.493406
https://doi.org/10.1101/2022.05.25.493406
Autor:
Ruorong Yan, Valentina Cigliola, Kelsey A. Oonk, Zachary Petrover, Sophia DeLuca, David W. Wolfson, Andrew Vekstein, Michelle A. Mendiola, Garth Devlin, Muath Bishawi, Matthew P. Gemberling, Tanvi Sinha, Michelle A. Sargent, Allen J. York, Avraham Shakked, Paige DeBenedittis, David C. Wendell, Jianhong Ou, Junsu Kang, Joseph A. Goldman, Gurpreet S. Baht, Ravi Karra, Adam R. Williams, Dawn E. Bowles, Aravind Asokan, Eldad Tzahor, Charles A. Gersbach, Jeffery D. Molkentin, Nenad Bursac, Brian L. Black, Kenneth D. Poss
Publikováno v:
Cell stem cell. 30(1)
The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find that tissue-regeneration enhancer elements (TR