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Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome.

Autor: Kebaier C, Chamberland RR, Allen IC, Gao X, Broglie PM, Hall JD, Jania C, Doerschuk CM, Tilley SL, Duncan JA, Kebaier, Chahnaz, Chamberland, Robin R, Allen, Irving C, Gao, Xi, Broglie, Peter M, Hall, Joshua D, Jania, Corey, Doerschuk, Claire M, Tilley, Stephen L, Duncan, Joseph A

Publikováno v: Journal of Infectious Diseases; 3/1/2012, Vol. 205 Issue 5, p807-817, 11p

Not just for lymphoid cells: the role of the noncanonical NF-κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders.

Autor: Trusiano B; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA 24061, United States., Zimmerman KL; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA 24061, United States., Morrison HA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA 24061, United States., Allen IC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA 24061, United States.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Jul 25; Vol. 116 (2), pp. 297-306.

Irreversible electroporation promotes a pro-inflammatory tumor microenvironment and anti-tumor immunity in a mouse pancreatic cancer model.

Autor: Imran KM; Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States., Brock RM; Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States., Beitel-White N; Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States., Powar M; Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States., Orr K; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States., Aycock KN; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States., Alinezhadbalalami N; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States., Salameh ZS; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States., Eversole P; Virginia Polytechnic Institute and State University, Blacksburg, VA, United States., Tintera B; Department of Surgery, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA, United States., Markov Madanick J; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States., Hendricks-Wenger A; Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States., Coutermarsh-Ott S; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States., Davalos RV; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States., Allen IC; Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.; Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Apr 22; Vol. 15, pp. 1352821. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).

NF-κB Inducing Kinase Attenuates Colorectal Cancer by Regulating Noncanonical NF-κB Mediated Colonic Epithelial Cell Regeneration.

Autor: Morrison HA; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia., Eden K; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia; Virginia Tech, Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, Virginia., Trusiano B; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia., Rothschild DE; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia., Qin Y; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina., Wade PA; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina., Rowe AJ; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia., Mounzer C; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia., Stephens MC; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia., Hanson KM; Via College of Osteopathic Medicine, Department of Cell Biology and Physiology, Spartanburg, South Carolina., Brown SL; Via College of Osteopathic Medicine, Department of Cell Biology and Physiology, Spartanburg, South Carolina., Holl EK; Duke University, Department of Surgery, Durham, North Carolina., Allen IC; Virginia Tech, Virginia Maryland College of Veterinary Medicine, Department of Biomedical Science and Pathobiology, Blacksburg, Virginia; Virginia Tech, Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, Virginia. Electronic address: icallen@vt.edu.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2024; Vol. 18 (3), pp. 101356. Date of Electronic Publication: 2024 May 14.