Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Allen H. Heller"'
Publikováno v:
Epilepsia
Objective Diazepam buccal film (DBF) is in development for treatment of patients experiencing bouts of increased seizure activity. We assessed safety, tolerability, and usability of self‐ or caregiver‐administered DBF in the outpatient setting. M
Autor:
Stephen Paul Wargacki, David J. Wyatt, A. Mark Schobel, Allen H. Heller, Buan Carla Valenti, Cassie Jung
Publikováno v:
Epilepsia. 59:2153-2161
Objective Clobazam oral soluble film (COSF) is a novel dosage form under development for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome. The present study was undertaken to assess the pharmacokinetics of clobazam adminis
Autor:
Michael A. Rogawski, Allen H. Heller
Publikováno v:
Epilepsybehavior : EB. 101
Benzodiazepines, including diazepam and midazolam, are the mainstay of treatment for seizure emergencies, including acute repetitive seizures. Nonparenteral dosage forms are used when parenteral (intravenous or intramuscular) dosing is not feasible.
Publikováno v:
Clinical Pharmacokinetics. 40:11-18
Moxifloxacin is a new 8-methoxyfluoroquinolone with a broad antibacterial spectrum. The purpose of the present study was to determine the effects of age and gender on pharmacokinetics, surrogate pharmacodynamics, safety and tolerability of a single d
Autor:
Debra S. Israel, William Rock, John T. Lettieri, Charles D. Sintek, John P. Toscano, Catherine Klein, Jennifer L. Stotka, Allen H. Heller, William R. Swaim, Ron E. Polk, Alan K. Kamada, Robert E. Pluhar
Publikováno v:
Clinical Infectious Diseases. 22:251-256
To determine if ciprofloxacin therapy alters the response to warfarin treatment, 36 adult patients attending three university-affiliated outpatient anticoagulation clinics randomly received a 12-day course of ciprofloxacin (750 mg twice daily) and a
Autor:
Pavur Sundaresan, John Lettieri, Allen H. Heller, John J. Sramek, Neal R. Cutler, Suzanne Sawin
Publikováno v:
Annals of Pharmacotherapy. 28:1143-1148
OBJECTIVE: To evaluate the safety and tolerance of intravenous nimodipine administered via a peripheral vein in healthy male volunteers. DESIGN: Double-blind, placebo- and vehicle-controlled trial with three fixed-dose panels. SETTING: Inpatient infu
Publikováno v:
European journal of clinical pharmacology. 56(12)
The pharmacokinetics, safety, and tolerability of cerivastatin, a synthetic HMG-CoA reductase inhibitor were studied in 49 healthy volunteers. In this double-blind, parallel group, multiple-dose study, volunteers were randomized as age-matched, male-
Autor:
Glenn Sipes, Harry Olson, Gerald Kolaja, Bruce Berger, Allen H. Heller, A.M. Monro, Patrick D. Lilly, Graham Betton, Peter Smith, Denise Robinson, Koen Van Deun, Karluss Thomas, Michael A. Dorato, James E. Sanders, William Bracken
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 32(1)
This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop (April 1999), which served to better understand concordance of the toxicity of pharmaceuti
Autor:
Jeffrey A. Stritar, José M. Vega, Jack A. Cook, Man-Wai Lo, Allen H. Heller, Andrew T. Chow, Brian P. Smith, Jeffrey S. Barrett, Scott D. Patterson, A. Lawrence Gould, Névine Zariffa, Vijay Batra
Publikováno v:
Journal of clinical pharmacology. 40(6)
The Food and Drug Administration (FDA) issued a second-draft guidance in August 1999 on the subject of in vivo bioequivalence, which is based on the concepts of individual and population bioequivalence (IBE and PBE, respectively). The intention of th
Autor:
Jeffrey A. Stritar, A. Lawrence Gould, Jack A. Cook, Jeffrey S. Barrett, José M. Vega, Man-Wai Lo, Scott D. Patterson, Névine Zariffa, Allen H. Heller, Vijay Batra, Andrew T. Chow, Brian P. Smith
Publikováno v:
Journal of clinical pharmacology. 40(6)