Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Allen G Cai"'
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219999 (2019)
While pigs and rabbits are used as models for human immune diseases, FcγR binding is poorly characterized in both test species. To evaluate antibody binding to FcγRIIIA, a receptor involved in antibody-dependent cellular cytotoxicity, chimerized an
Externí odkaz:
https://doaj.org/article/da49978ff79a4f018a5599a517d06552
Autor:
Sindy Liao-Chan, Barbara Daine-Matsuoka, Nathan Heald, Tiffany Wong, Tracey Lin, Allen G Cai, Michelle Lai, Joseph A D'Alessio, Jan-Willem Theunissen
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124708 (2015)
Antibodies against cell surface antigens may be internalized through their specific interactions with these proteins and in some cases may induce or perturb antigen internalization. The anti-cancer efficacy of antibody-drug conjugates is thought to r
Externí odkaz:
https://doaj.org/article/36d07d62512441548835e2f6c9405095
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9af9f3eb10a892b4846b80595d9a01
https://doi.org/10.1158/1535-7163.c.6537849.v1
https://doi.org/10.1158/1535-7163.c.6537849.v1
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Table S1. Screening Data; Supplementary Table S2. Binding Data; Supplementary Table S3. TGA Data; Supplementary Table S4. ADC Data With Ranking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db7bae4996febd810a10a32193713f
https://doi.org/10.1158/1535-7163.22504785
https://doi.org/10.1158/1535-7163.22504785
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab831a13a6726f0627401e143473ccb
https://doi.org/10.1158/1535-7163.22504788.v1
https://doi.org/10.1158/1535-7163.22504788.v1
Autor:
Allen G. Cai, Jeffrey Eastham-Anderson, Wyne P. Lee, Thijs J. Hagenbeek, Janet Tao, Ho-June Lee, Joshua D. Webster, Michele Carbone, Klara Totpal, Xiumin Wu, Trang H. Pham, Boris C. Bastian, Dwight Barnes, Anwesha Dey, Matthew T. Chang, Xu Chen, Rajkumar Noubade, Christopher Tran
Publikováno v:
Cancer Research. 80:1656-1668
The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk for mesothelioma and melanocytic tumors. Here, we show that pancreatic intraepithelial neoplasia driven by oncogenic mutant KrasG12D progressed to pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a14a2752b77e130678bf7c2adf0822
https://doi.org/10.1158/0008-5472.can-19-1704
https://doi.org/10.1158/0008-5472.can-19-1704
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219999 (2019)
PLoS ONE, Vol 14, Iss 7, p e0219999 (2019)
While pigs and rabbits are used as models for human immune diseases, FcγR binding is poorly characterized in both test species. To evaluate antibody binding to FcγRIIIA, a receptor involved in antibody-dependent cellular cytotoxicity, chimerized an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9bb6dccefa3c0e9414ffe2badd01a3
https://pubmed.ncbi.nlm.nih.gov/31323052
https://pubmed.ncbi.nlm.nih.gov/31323052
Autor:
Thijs J. Hagenbeek, Xiumin Wu, Matthew T. Chang, Wyne P. Lee, Christiaan Klijn, Shuqun Yang, Joshua D. Webster, Noelyn M. Kljavin, Kevin Walsh, Qunsheng Ji, Zhixiang Zhang, Anwesha Dey, Dae-Sik Lim, Buvana Ravishankar, Da-Hye Lee, Georgia Hatzivassiliou, Cecile de la Cruz, Stephen E. Gould, Naiying Yang, Qingyang Gu, Ho-June Lee, Trang H. Pham, Erica L. Jackson, Klara Totpal, Allen G. Cai
Publikováno v:
Science signaling. 11(547)
The Hippo signaling pathway regulates organ size and plays critical roles in maintaining tissue growth, homeostasis, and regeneration. Dysregulated in a wide spectrum of cancers, in mammals, this pathway is regulated by two key effectors, YAP and TAZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f067183d0b2e82e2ad8e85e5fd1a5ac
https://pubmed.ncbi.nlm.nih.gov/30301931
https://pubmed.ncbi.nlm.nih.gov/30301931
Autor:
Allen G. Cai, Ryan Dorfman, Thi-Sau Migone, Avery Andrew, Sebastian Guelman, Cooper Anthony, Zoia Levashova, Jan-willem Theunissen, Maryam M. Bhatti
Publikováno v:
Molecular cancer therapeutics. 17(11)
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d114a6e46087c6a73c7738a64fa338
https://pubmed.ncbi.nlm.nih.gov/30126944
https://pubmed.ncbi.nlm.nih.gov/30126944
Autor:
Bruce S. Baker, Yi Chen, Adam R. Renslo, Devanand S. Manoli, Sara Kwong, Neha Agarwal, Allen G. Cai, Nirao M. Shah, Osama M. Ahmed, Jeffrey Neitz, Pu Fan
Publikováno v:
Cell, vol 154, iss 1
Summary Genetically hard-wired neural mechanisms must enforce behavioral reproductive isolation because interspecies courtship is rare even in sexually naive animals of most species. We find that the chemoreceptor Gr32a inhibits male D. melanogaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554c46a20db45c4b3efb07ccb6c159cf
https://doi.org/10.1016/j.cell.2013.06.008
https://doi.org/10.1016/j.cell.2013.06.008