Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Allen Delaney"'
Autor:
Anamaria Crisan, Rodrigo Goya, Gavin Ha, Jiarui Ding, Leah M Prentice, Arusha Oloumi, Janine Senz, Thomas Zeng, Kane Tse, Allen Delaney, Marco A Marra, David G Huntsman, Martin Hirst, Sam Aparicio, Sohrab Shah
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41551 (2012)
Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome-in particular single nucleotide variants (SNVs). Most current computational and statistical models for analyzing next generati
Externí odkaz:
https://doaj.org/article/c839d4c639fe4c849330294810dba997
Autor:
Ryan Chao, Linda Nevin, Pooja Agarwal, Jan Riemer, Xiaoyang Bai, Allen Delaney, Matthew Akana, Nelson JimenezLopez, Tanya Bardakjian, Adele Schneider, Nicolas Chassaing, Daniel F Schorderet, David FitzPatrick, Pui-yan Kwok, Lars Ellgaard, Douglas B Gould, Yan Zhang, Jarema Malicki, Herwig Baier, Anne Slavotinek
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10565 (2010)
Anophthalmia and microphthalmia are important birth defects, but their pathogenesis remains incompletely understood. We studied a patient with severe unilateral microphthalmia who had a 2.7 Mb deletion at chromosome 18q22.1 that was inherited from hi
Externí odkaz:
https://doaj.org/article/ef919a3345ee40cd9928bcccce3d8081
Autor:
Richard A. Moore, Marco A. Marra, Peggy L. Olive, W. Jim Morris, Michael McKenzie, Alexander Agranovich, Cindy Yang, Karen Novik, Dallas Thomas, Martin Krzywinski, Allen Delaney, Lorena Barclay, Mira Keyes, Trevor J. Pugh
Purpose: The presence of intrinsic radiosensitivity within prostate cancer patients may be an important factor contributing to development of radiation toxicity. We investigated whether variants in genes responsible for detecting and repairing DNA da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec0fa2bc9df32ee382b2d1dd214b4bc
https://doi.org/10.1158/1078-0432.c.6518596
https://doi.org/10.1158/1078-0432.c.6518596
Autor:
Richard A. Moore, Marco A. Marra, Peggy L. Olive, W. Jim Morris, Michael McKenzie, Alexander Agranovich, Cindy Yang, Karen Novik, Dallas Thomas, Martin Krzywinski, Allen Delaney, Lorena Barclay, Mira Keyes, Trevor J. Pugh
Supplementary Data from Sequence Variant Discovery in DNA Repair Genes from Radiosensitive and Radiotolerant Prostate Brachytherapy Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fcd3e7cf11ee6e038ae6aa75386a03e
https://doi.org/10.1158/1078-0432.22441591
https://doi.org/10.1158/1078-0432.22441591
Autor:
Jacques L. Michaud, Tracy Tucker, Sylvia Dobrzeniecka, Fadi F. Hamdan, Farah R. Zahir, David Chai, Emmanuelle Lemyre, Jan M. Friedman, Patrice Eydoux, Erica S Tsang, Malachi Griffith, Marco A. Marra, Allen Delaney, Sylvie Langlois
Publikováno v:
European Journal of Human Genetics. 22:792-800
Intellectual disability affects about 3% of individuals globally, with∼50% idiopathic. We designed an exonic-resolution array targeting all known submicroscopic chromosomal intellectual disability syndrome loci, causative genes for intellectual dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2b8d3304ac486a465b864625ca93f7
https://doi.org/10.1038/ejhg.2013.248
https://doi.org/10.1038/ejhg.2013.248
Autor:
Michelle Moksa, Angela Tam, Readman Chiu, Kane Tse, Malachi Griffith, Sa Li, Karen Mungall, Eric Y. Zhao, Barbara Meissner, Shaun D. Jackman, Bruce Woolcock, Matthew A. Field, Susanna Chan, Merrill Boyle, Martin Hirst, David W. Scott, Susana Ben-Neriah, John J. Spinelli, Yaron S.N. Butterfield, Duane E. Smailus, Allen Delaney, Marco A. Marra, Yongjun Zhao, Oleksandr Yakovenko, Sanja Rogic, Angela Brooks-Wilson, Jessica Tamura-Wells, Nathalie A. Johnson, Diane L. Trinh, Randy D. Gascoyne, Irmtraud M. Meyer, Jacqueline E. Schein, Rodrigo Goya, Suganthi Chittaranjan, Robert A. Holt, Joseph M. Connors, Andrew J. Mungall, Ryan D. Morin, Steven J.M. Jones, Maria Mendez-Lago, Marlo Firme, Tesa M. Severson, Lisa M. Rimsza, Richard A. Moore, Helen McDonald, Martin Krzywinski, Douglas E. Horsman, Thomas Zeng, Inanc Birol, Richard Corbett
Publikováno v:
Nature
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f717b6b01a8380085cdaba57298f8ef
https://doi.org/10.1038/nature10351
https://doi.org/10.1038/nature10351
Autor:
Kobor, J Swingland, Dan Goldowitz, B Argiropoulos, AK Fok, Anna Lehman, L Avila, Patrice Eydoux, Cornelius F. Boerkoel, David Chai, Allen Delaney, Barbara McGillivray, C. du Souich, JL Huang
Publikováno v:
Clinical Genetics. 81:56-63
Up to 90% of individuals affected by Sotos syndrome have a pathogenic alteration of NSD1 (encodes nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1), a histone methyltransferase that functions as both a transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa33db9bd5e6e1b27c1c1a3d58acbf1
https://doi.org/10.1111/j.1399-0004.2010.01615.x
https://doi.org/10.1111/j.1399-0004.2010.01615.x
Autor:
Marco A. Marra, Gulisa Turashvili, Michael S. Anglesio, Steve E. Kalloger, Niki Boyd, Andrew McPherson, Sian Fereday, Diane Provencher, Ryan Giuliany, Patricia N. Tonin, Jason Madore, Blake Gilks, Angela Tam, Osama M. Al-Agha, Nataliya Melnyk, David D.L. Bowtell, Stephen Yip, Gavin Ha, Christine Chow, Kane Tse, Samuel Aparicio, Allen Delaney, Lynda Bell, Anne Marie Mes-Masson, Alireza Heravi-Moussavi, Thomas Zeng, Laura Galletta, Yongjun Zhao, Janine Senz, Steven J.M. Jones, Sohrab P. Shah, Martin Hirst, Gregg B. Morin, Ie Ming Shih, Winnie Yang, Leah M Prentice, David G. Huntsman, Dianne Miller, Kimberly C. Wiegand, Melissa K. McConechy, Abdalnasser Zayed, John Fee, Arusha Oloumi, Richard A. Moore
Publikováno v:
New England Journal of Medicine. 363:1532-1543
Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described.We sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d39c15c6b25a624c301dd4879140e9
https://doi.org/10.1056/nejmoa1008433
https://doi.org/10.1056/nejmoa1008433
Autor:
Gregg B. Morin, Allen Delaney, A. Sorana Morrissy, Yongjun Zhao, Haiyan I. Li, Richard Corbett, Isabella T. Tai, Rodrigo Goya, Michelle J. Tang, Adrian Ally, Helen McDonald, Ryan D. Morin, Gordon Robertson, Jennifer Asano, Suganthi Chittaranjan, Trevor J. Pugh, Jill Mwenifumbo, Thomas Zeng, Ying-Chen Hou, Kevin Teague, Obi L. Griffith, Malachi Griffith, Susanna Y. Chan, Marco A. Marra, Martin Hirst, Steven J.M. Jones
Publikováno v:
Nature Methods. 7:843-847
In alternative expression analysis by sequencing (ALEXA-seq), we developed a method to analyze massively parallel RNA sequence data to catalog transcripts and assess differential and alternative expression of known and predicted mRNA isoforms in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf34ad6a62f79474a35b8038a4ca3a
https://doi.org/10.1038/nmeth.1503
https://doi.org/10.1038/nmeth.1503
Autor:
Gustavo Turecki, Mikhail Bilenky, Joseph F. Costello, Chris Fiore, Martin Hirst, Tracy J. Ballinger, Nina Thiessen, Allen Delaney, Cydney B. Nielsen, Ting Wang, Vivi M. Heine, David Haussler, Brett E. Johnson, Xiaoyun Xing, Steven J.M. Jones, Yongjun Zhao, Shaun D. Fouse, Marco A. Marra, Raman P. Nagarajan, David H. Rowitch, Richard Varhol, Alika K. Maunakea, Chibo Hong, Maximiliaan Schillebeeckx, Cletus D'Souza, Ksenya Shchors
Publikováno v:
Nature, vol 466, iss 7303
Nature, 466(7303), 253-7. Nature Publishing Group
Nature
Maunakea, A K, Nagarajan, R P, Bilenky, M, Ballinger, T J, D'Souza, C, Fouse, S D, Johnson, B E, Hong, C, Nielsen, C, Zhao, Y, Turecki, G, Delaney, A, Varhol, R, Thiessen, N, Shchors, K, Heine, V M, Rowitch, D H, Xing, X, Fiore, C, Schillebeeckx, M, Jones, S J M, Haussler, D, Marra, M A, Hirst, M, Wang, T & Costello, J F 2010, ' Conserved role of intragenic DNA methylation in regulating alternative promoters ', Nature, vol. 466, no. 7303, pp. 253-7 . https://doi.org/10.1038/nature09165
Nature, 466(7303), 253-7. Nature Publishing Group
Nature
Maunakea, A K, Nagarajan, R P, Bilenky, M, Ballinger, T J, D'Souza, C, Fouse, S D, Johnson, B E, Hong, C, Nielsen, C, Zhao, Y, Turecki, G, Delaney, A, Varhol, R, Thiessen, N, Shchors, K, Heine, V M, Rowitch, D H, Xing, X, Fiore, C, Schillebeeckx, M, Jones, S J M, Haussler, D, Marra, M A, Hirst, M, Wang, T & Costello, J F 2010, ' Conserved role of intragenic DNA methylation in regulating alternative promoters ', Nature, vol. 466, no. 7303, pp. 253-7 . https://doi.org/10.1038/nature09165
Although it is known that the methylation of DNA in 5' promoters suppresses gene expression, the role of DNA methylation in gene bodies is unclear. In mammals, tissue- and cell type-specific methylation is present in a small percentage of 5' CpG isla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f24e873e54aeb52d94220405df9a455
https://doi.org/10.1038/nature09165
https://doi.org/10.1038/nature09165