Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Allen Darin Arthur"'
Autor:
Paul A. Sprengeler, Hui Hon Chung, Martin Sendzik, Vincent W.-F. Tai, Jeffrey R. Spencer, Bradley A. Katz, Richard L. Mackman, William D. Shrader, Allen Darin Arthur, Kyle Elrod, J. Guy Breitenbucher, Erik Verner, James W. Janc, Christine Luong, Aleks Kolesnikov
Publikováno v:
Journal of Molecular Biology. 329:93-120
An extensive structural manifold of short hydrogen bond-mediated, active site-directed, serine protease inhibition motifs is revealed in a set of over 300 crystal structures involving a large suite of small molecule inhibitors (2-(2-phenol)-indoles a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a68e4fa40fb459974b7e61705ec74a
https://doi.org/10.1016/s0022-2836(03)00399-1
https://doi.org/10.1016/s0022-2836(03)00399-1
Autor:
Bradley A. Katz, Danny McGee, Martin Sendzik, Christine Luong, Richard L. Mackman, Jeffrey R. Spencer, Allen Darin Arthur, Neil H. Squires
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2023-2026
The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e511779851ef634ec4a86932cdff4a
https://doi.org/10.1016/s0960-894x(02)00312-8
https://doi.org/10.1016/s0960-894x(02)00312-8
Autor:
Kesavan Radika, William D. Shrader, Bradley A. Katz, Hui Hon Chung, Wendy B. Young, Aleksandr Kolesnikov, Jeffrey R. Spencer, Sean G. Trapp, Jason M. Hataye, Allen Darin Arthur, Christine Luong, Erik Verner, Paul A. Sprengeler, Arnold Martelli, Miles She, Hruzewicz Witold N, Yong Li, Jing Wang, Roopa Rai, Richard L. Mackman
Publikováno v:
Journal of Medicinal Chemistry. 44:2753-2771
Novel scaffolds that bind to serine proteases through a unique network of short hydrogen bonds to the catalytic Ser195 have been developed. The resulting potent serine protease inhibitors were designed from lead molecule 2-(2-hydroxyphenyl)1H-benzoim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eb924621da3ae0112de3587d0f31c4
https://doi.org/10.1021/jm0100638
https://doi.org/10.1021/jm0100638
Autor:
Yong Li, Lynne Cregar, Jana Burgess-Henry, Ellen M. Leahy, Allen Darin Arthur, Erik Verner, Wendy B. Young, Aleksandr Kolesnikov, Roopa Rai, William D. Shrader, Xi Chen, Bradley A. Katz, Paul A. Sprengeler, Kyle Elrod, Christine Luong, Joan Sangalang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1797-1800
The development of potent and selective small molecule inhibitors of factor Xa is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff49a67d4177d7e7b2ee9496efe25ae9
https://doi.org/10.1016/s0960-894x(01)00311-0
https://doi.org/10.1016/s0960-894x(01)00311-0
Autor:
Mark Rice, Allen Darin Arthur, Bradley A. Katz, Jeffrey R. Spencer, Christine Luong, Paul A. Sprengeler, James W. Janc, Kyle Elrod, Richard L. Mackman
Publikováno v:
Journal of the American Chemical Society. 124(39)
We describe and compare the pH dependencies of the potencies and of the bound structures of two inhibitor isosteres that form multicentered short hydrogen bond arrays at the active sites of trypsin, thrombin, and urokinase type plasminogen activator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3590472783870ef12dd459d1ed2900ad
https://pubmed.ncbi.nlm.nih.gov/12296731
https://pubmed.ncbi.nlm.nih.gov/12296731
Autor:
James W. Janc, Kyle Elrod, Bradley A. Katz, Arnold Martelli, Hui Hon Chung, Allen Darin Arthur, Danny McGee, Jeffrey R. Spencer, Paul A. Sprengeler, Erik Verner, Christine Luong, J. Guy Breitenbucher, Richard L. Mackman, Matt Kirtley
Publikováno v:
Chemistrybiology. 8(11)
Background: Involved or implicated in a wide spectrum of diseases, trypsin-like serine proteases comprise well studied drug targets and anti-targets that can be subdivided into two major classes. In one class there is a serine at position 190 at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2586278776d9092ee37b4c8a697b322c
https://pubmed.ncbi.nlm.nih.gov/11731301
https://pubmed.ncbi.nlm.nih.gov/11731301