Výsledky vyhledávání - "Allen D Kline"

Complete Relative Stereochemistry of Multiple Stereocenters Using Only Residual Dipolar Couplings

Autor: Allen D. Kline, Edward R. Zartler, Huaping Mo, Tim A. Smitka, Frank Delaglio, Gregory A. Stephenson, Jiangli Yan, Andreas Kaerner, Michael J. Shapiro

Publikováno v: Journal of the American Chemical Society. 126:5008-5017

Residual dipolar couplings (RDCs), in combination with molecular order matrix calculations, were used to unambiguously determine the complete relative stereochemistry of an organic compound with five stereocenters. Three simple one-dimensional experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b47b0cb37b46c4913cef412711aac49
https://doi.org/10.1021/ja037605q

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The effect of relaxation on the epitope mapping by saturation transfer difference NMR

Autor: Allen D. Kline, Jiangli Yan, Edward R. Zartler, Michael J. Shapiro, Huaping Mo

Publikováno v: Journal of Magnetic Resonance. 163:270-276

The effect of longitudinal relaxation of ligand protons on saturation transfer difference (STD) was investigated by using a known binding system, dihydrofolate reductase and trimethoprim. The results indicate that T1 relaxation of ligand protons has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2f65c80f2efb1482e4f59fe31efe08
https://doi.org/10.1016/s1090-7807(03)00106-x

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1D NMR Methods in Ligand-Receptor Interactions

Autor: Jiangli Yan, Michael J. Shapiro, Allen D. Kline, Edward R. Zartler, Huaping Mo

Publikováno v: Current Topics in Medicinal Chemistry. 3:25-37

The drug discovery process often involves the screening of compound libraries to identify drug candidates capable of binding to target macromolecules. New approaches in biological and chemical research are driving a change in the pharmaceutical indus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b267bb077d0468eb7d018522df24c52
https://doi.org/10.2174/1568026033392750

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Template Requirements for RNA Synthesis by a Recombinant Hepatitis C Virus RNA-Dependent RNA Polymerase

Autor: Xueyong Yang, Allen D. Kline, Q. May Wang, Donna Barket, C. Cheng Kao, Beverly A. Heinz

Publikováno v: Journal of Virology. 74:11121-11128

The RNA-dependent RNA polymerase (RdRp) from hepatitis C virus (HCV), nonstructural protein 5B (NS5B), has recently been shown to direct de novo initiation using a number of complex RNA templates. In this study, we analyzed the features in simple RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca6488c6360a502f3e048d61d2f9021
https://doi.org/10.1128/jvi.74.23.11121-11128.2000

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Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere

Autor: Jeffrey T. Mullaney, Matthew J. Fisher, Barbara G. Utterback, Bruce P. Gunn, Cathy S. Harms, Suzane L. Um, Robert M. Scarborough, Joseph A. Jakubowski, Allen D. Kline, Marshall Alan Skelton

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2537-2542

Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C6 and a β-substituted aspartate mimic at C2 offer enhanced affinity for GPIIb–IIIa relative to the non-substituted isoquinolone propionate. Alkyl substituents affo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b87bf8823241436e50dd679a4a440695
https://doi.org/10.1016/s0960-894x(97)10014-2

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Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn: Potent Antagonists of Platelet Glycoprotein IIb−IIIa

Autor: Jeffrey T. Mullaney, Cathy S. Harms, Joseph A. Jakubowski, Matthew J. Fisher, Ann E. Arfsten, Marshall Alan Skelton, Suzane L. Um, Bruce P. Gunn, Anne Marie Nunes, Allen D. Kline, Robert M. Scarborough, Barbara G. Utterback

Publikováno v: Journal of Medicinal Chemistry. 40:2085-2101

Cyclic heptapeptide 1, which contains an Arg-Gly-Asp sequence, has good affinity for the platelet receptor GPIIb-IIIa and was chosen for study by 1H NMR techniques. The key RGD sequence of this molecule was found to reside in a conformationally defin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c82c14a236a699dd6c9163d749483a3
https://doi.org/10.1021/jm9701076

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Glutamine-derived aldehydes for the inhibition of human rhinovirus 3C protease

Autor: Bruce A. Dressman, J. M. Labus, Allen D. Kline, Beverly A. Heinz, M. Hammond, F. W. Chadwell, Stephen W. Kaldor

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2021-2026

Peptide aldehydes have been synthesized and evaluated as inhibitors of human rhinovirus 3C protease. Those inhibitors containing a C-terminal glutamine aldehyde were prepared using newly developed methodology involving reduction of the corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e650f9e93040a235149721269ed9496
https://doi.org/10.1016/0960-894x(95)00345-t

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