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pro vyhledávání: '"Allen Cheever"'
Autor:
Luke Barron, Amber M Smith, Karim C El Kasmi, Joseph E Qualls, Xiaozhu Huang, Allen Cheever, Lee A Borthwick, Mark S Wilson, Peter J Murray, Thomas A Wynn
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61961 (2013)
Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs). AAMs modulate T cell and wound healing responses and Arg1 might contribute to asthma pathogenesis by inhibiting nitric oxide production
Externí odkaz:
https://doaj.org/article/3070d76f60e94c6381d4c5f639a7299c
Autor:
Thirumalai Ramalingam, Luke Barron, Margaret Mentink-Kane, Allen Cheever, Alison Humbles, Roland Kolbeck, Thomas Wynn
Publikováno v:
The Journal of Immunology. 186:58.9-58.9
The mouse Breast Regression Protein 39 (BRP39; Chi3l1) is a chitinase like protein but lacks enzymatic activity. Recently it was shown that mice lacking BRP39 displayed significantly impaired Th2 response during allergic airway disease. We sought to
Autor:
Thomas Wynn, Thirumalai Ramalingam, Satish Madala, Robert Thompson, Margaret Mentink, Luke Barron, Allen Cheever, Mark Wilson
Publikováno v:
The Journal of Immunology. 184:134.8-134.8
TH2 cytokines regulate inflammation, mucus production, tissue remodeling, and fibrosis. Consequently, they have become important therapeutic targets for a number of debilitating illnesses, including asthma, idiopathic pulmonary fibrosis, ulcerative c