Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Allen A. Fienberg"'
A review of the pharmacology and clinical profile of lumateperone for the treatment of schizophrenia
Autor:
Gretchen L. Snyder, Peng Li, Robert E. Davis, Sharon Mates, Kimberly E. Vanover, Allen A. Fienberg
Publikováno v:
A Tribute to Paul Greengard (1925-2019) ISBN: 9780128225165
Schizophrenia is associated with a tremendous individual and societal burden. The disease is characterized by a complex set of symptoms including psychosis, hallucinations, delusions and related positive symptoms combined with social function deficit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac6e5c1ac264ecc9af1a992429900e0
https://doi.org/10.1016/bs.apha.2020.09.001
https://doi.org/10.1016/bs.apha.2020.09.001
Autor:
Allen A. Fienberg, Gretchen L. Snyder, Peter John, Robert E. Davis, Marc V. Pulanco, Xingxing Zang
Publikováno v:
Cancer Research. 81:1243-1243
We investigated the effect of ITI-214, a selective phosphodiesterase type 1 (PDE-1) inhibitor [Li et al., J Med Chem, 2016, 1149-64] on immune cell composition of the tumor microenvironment, tumor volume and survival in syngeneic mouse model of color
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b2b2a48e1feda3879d9a1fb1bbe14d
https://doi.org/10.1158/1538-7445.am2021-1243
https://doi.org/10.1158/1538-7445.am2021-1243
Autor:
Alex Sonneborn, Bogachan Sahin, Gabriel Mettlach, Theresa E. Bjorness, Nicholas Dale, James A. Bibb, Masashi Yanagisawa, Allen A. Fienberg, Robert W. Greene
Publikováno v:
The Journal of Neuroscience. 36:3709-3721
Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves during subsequent sleep. Here we demonstrate that mice deficient for glial adenosine kinase (AdK), the primary metabolizing enzyme for adenosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbe1cce6ff85f681b01b4b58ab25111
https://doi.org/10.1523/jneurosci.3906-15.2016
https://doi.org/10.1523/jneurosci.3906-15.2016
Autor:
Mahomi Kuroiwa, Marc Flajolet, Miho Hamada, Naoki Sotogaku, Eriko Hieda, Akinori Nishi, Takahide Shuto, Gretchen L. Snyder, Allen A. Fienberg, Joseph P. Hendrick
Publikováno v:
Neuropharmacology. 63:1248-1257
Muscarinic receptors, activated by acetylcholine, play critical roles in the functional regulation of medium spiny neurons in the striatum. However, the muscarinic receptor signaling pathways are not fully elucidated due to their complexity. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbe37f6664e32c2392f29802df227b2
https://doi.org/10.1016/j.neuropharm.2012.07.046
https://doi.org/10.1016/j.neuropharm.2012.07.046
Autor:
Véronique Sgambato-Faure, Angus C. Nairn, Allen A. Fienberg, Eric J. Nestler, Teresa Sasaki, Per Svenningsson, Olivier Berton, Venetia Zachariou, Paul Greengard
Publikováno v:
Neuropsychopharmacology
Neuropsychopharmacology, Nature Publishing Group, 2006, 31 (3), pp.555-62. ⟨10.1038/sj.npp.1300832⟩
Neuropsychopharmacology, Nature Publishing Group, 2006, 31 (3), pp.555-62. ⟨10.1038/sj.npp.1300832⟩
International audience; Mice lacking DARPP-32, a striatal-enriched phosphoprotein, show abnormal behavioral and biochemical responses to cocaine, but the role of individual phosphorylation sites in DARPP-32 in these responses is unknown. We show here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb86f109a99a27340830494ddfe3292
https://doi.org/10.1038/sj.npp.1300832
https://doi.org/10.1038/sj.npp.1300832
Autor:
Angus C. Nairn, Bogachan Sahin, Jozef Spychala, Steven E. Ealick, James A. Bibb, Allen A. Fienberg, Robert W. Greene, Janice W. Kansy
Publikováno v:
European Journal of Biochemistry. 271:3547-3555
The regulation of adenosine kinase (AK) activity has the potential to control intracellular and interstitial adenosine (Ado) concentrations. In an effort to study the role of AK in Ado homeostasis in the central nervous system, two isoforms of the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58cfaf06c9d3bdd16a681aeb628bbe39
https://doi.org/10.1111/j.1432-1033.2004.04291.x
https://doi.org/10.1111/j.1432-1033.2004.04291.x
Autor:
Orna Tighe, Allen A. Fienberg, Paul Greengard, John L. Waddington, Anthony Kinsella, Rachel E. Nally, David T. Croke
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:1281-1287
Given the critical role of dopamine- and adenosine 3′,5′-monophosphate-regulated phosphoprotein of 32 kDa (DARPP-32) in the regulation of dopaminergic function, DARPP-32-null mutant mice congenic on the inbred C57BL/6 strain for 10 generations we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1666ca528ddcc6ea13c504278ffd471c
https://doi.org/10.1124/jpet.104.068957
https://doi.org/10.1124/jpet.104.068957
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:870-879
The phosphoprotein DARPP-32 (dopamine and cAMP-regulated phosphoprotein 32 kDa) plays a central role in mediating the actions of a variety of neurotransmitters in medium spiny neurons of the striatum (Greengard, 1990; Fienberg et al., 1998). This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214787ff4f62177e929123968ebeec32
https://doi.org/10.1124/jpet.103.050062
https://doi.org/10.1124/jpet.103.050062
Autor:
Allen A. Fienberg, Carlos Cepeda, Paul Greengard, Christopher R. Calvert, Jorge Flores-Hernandez, Elizabeth Hernández-Echeagaray, Eve S. Jokel, Michael Levine
Publikováno v:
Journal of Neurophysiology. 88:3010-3020
Dopamine (DA), via activation of D1 receptors, enhances N-methyl-d-aspartate (NMDA)-evoked responses in striatal neurons. The present investigation examined further the properties of this enhancement and the potential mechanisms by which this enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103821d87ad4a190d78242f179bcc29e
https://doi.org/10.1152/jn.00361.2002
https://doi.org/10.1152/jn.00361.2002
Autor:
Per Svenningsson, James A. Bibb, Maria Lindskog, Bertil B. Fredholm, Allen A. Fienberg, Laura Pozzi, Angus C. Nairn, Paul Greengard, Gilberto Fisone, Yong Kim
Publikováno v:
Nature. 418:774-778
Caffeine has been imbibed since ancient times in tea and coffee, and more recently in colas. Caffeine owes its psychostimulant action to a blockade of adenosine A(2A) receptors, but little is known about its intracellular mechanism of action. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b998ed304cac6cfc7cb553af538e9a5
https://doi.org/10.1038/nature00817
https://doi.org/10.1038/nature00817