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Difluorinated thromboxane A 2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors.

Autor: Allen MF; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Hutchinson JL; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Keith M; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Mallah S; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Corey RA; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Trory JS; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Jing C; School of Chemistry, University of Bristol, Bristol, UK., Fang H; School of Chemistry, University of Bristol, Bristol, UK., Wei L; School of Chemistry, University of Bristol, Bristol, UK., Bennett SH; School of Chemistry, University of Bristol, Bristol, UK., Aggarwal VK; School of Chemistry, University of Bristol, Bristol, UK., Mundell SJ; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK., Hers I; School of Physiology, Pharmacology and Neuroscience, Faculty of Life Sciences, University of Bristol, Bristol, UK.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Oct; Vol. 181 (19), pp. 3685-3699. Date of Electronic Publication: 2024 Jun 05.