Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Allelotype Analysis"'
Autor:
Jesse Chung Sean Pang, Chengchuan Jiang, Carol Y.K. Tong, Liang Fu Zhou, J. Hu, X. I. Yin, Wai Sang Poon, B. Lau, Ho Keung Ng
Publikováno v:
British Journal of Cancer
Diffusely infiltrative astrocytic tumours are the most common neoplasms in the human brain. To localise putative tumour suppressor loci that are involved in low-grade astrocytomas, we performed high-resolution genome-wide allelotype analysis on 17 fi
Publikováno v:
Oncogene. 21:1461-1468
To identify critical tumor suppressor loci that are associated with the development of medulloblastoma, we performed a comprehensive genome-wide allelotype analysis in a series of 12 medulloblastomas. Non-random allelic imbalances were identified on
Autor:
Ilana Cass, Ella Fasylova, Beth Y. Karlan, Rae Lynn Baldwin, Abbie L. Fields, Carolyn D. Runowicz, Harold P. Klinger
Publikováno v:
Gynecologic Oncology. 82:69-76
Papillary serous peritoneal carcinoma (PSPC) is histologically indistinguishable from papillary serous ovarian carcinoma (PSOC) with a similar clinical presentation, yet may differ in its carcinogenesis. The purpose of this study was to determine the
Autor:
Atsuko Kanzaki, Takashi Aikou, Kohji Miyazaki, Takanori Morikawa, Miki Konno, Hitoshi Miyashita, Sonshin Takao, Takafumi Uchida, Yuji Takebayashi, Toru Fujioka, Manabu Fukumoto, Kentaro Nakayama
Publikováno v:
Cancer Letters. 166:135-141
Anomalous junction of pancreaticobiliary duct (AJPBD) patients has an increased risk of gallbladder and bile duct carcinomas. However, the relevance of carcinoma with AJPBD is not fully clarified. We performed analysis of loss of heterozygosity (LOH)
Autor:
Volker Diehl, M. Kornacker, R Kurt Thomas, Thomas Zander, Jörn Bullerdiek, Nadia Massoudi, Christa Fonatsch, Juergen Wolf, Andrea Staratschek-Jox
Publikováno v:
British Journal of Cancer
Hodgkin-Reed Sternberg cells are derived from germinal centre B-cells in most cases. Somatic mutations affecting their rearranged immunoglobulin genes were detected, rendering potential functional rearrangements non-functional. Under physiological co
Publikováno v:
British Journal of Cancer
Mutation of human homologues of DNA mismatch repair (MMR) genes in tumours has been shown to be associated with the phenomenon of microsatellite instability (MSI). Several studies have reported the occurrence of MSI in bladder cancer, but evidence of
Publikováno v:
Carcinogenesis. 21:1297-1301
Loss of heterozygosity (LOH) at specific chromosomal loci is generally considered indirect evidence for the presence of putative suppressor genes. Allelotyping of tumors using polymorphic markers distributed throughout the entire genome allows the an
Autor:
Bert A. Bonsing, Willem E. Corver, Anne-Marie Cleton-Jansen, Cees J. Cornelisse, Gert Jan Fleuren, Peter Devilee
Publikováno v:
Genes, Chromosomes and Cancer. 28:173-183
Flow cytometric DNA content measurements have demonstrated extensive DNA ploidy heterogeneity in primary breast carcinomas. However, little is known at the molecular level about the clonal relationship between these tumor cell subpopulations, or abou
Publikováno v:
Modern Pathology. 13:627-631
To identify the chromosomal loci of allelic loss in intrahepatic cholangiocarcinoma (ICC), we performed an allelotype study of 36 ICCs using 55 genome-wide microsatellite markers. Loss of heterozygosity was found most frequently on 8p (65.6%), 17p (6
Publikováno v:
Leukemia. 14:805-810
Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders found predominantly in the elderly. The molecular mechanisms underlying the development of MDS remain obscure. In order to begin to identify tumor suppressor genes involved i