Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Allegra Kaufman"'
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100057- (2020)
Summary: Experimental fibroblast growth factor 21 (FGF21) analogs can improve lipid profiles in patients with metabolic diseases. However, their effects on markers of insulin sensitivity appear to be minimal, potentially because of insufficient expos
Externí odkaz:
https://doaj.org/article/ff70adc410394e34a7243a26c6816dac
Autor:
Peter Winkle, Steven Goldsmith, Michael J. Koren, Serge Lepage, Jennifer Hellawell, Ashit Trivedi, Kate Tsirtsonis, Siddique A. Abbasi, Allegra Kaufman, Richard Troughton, Adriaan Voors, Jean-Sebastien Hulot, Erwan Donal, Navid Kazemi, Joel Neutel
Publikováno v:
Cardiovascular Drugs and Therapy
Cardiovascular Drugs and Therapy, Springer Verlag, 2022, ⟨10.1007/s10557-022-07328-w⟩
Cardiovascular Drugs and Therapy, 2022, ⟨10.1007/s10557-022-07328-w⟩
Cardiovascular Drugs and Therapy, Springer Verlag, 2022, ⟨10.1007/s10557-022-07328-w⟩
Cardiovascular Drugs and Therapy, 2022, ⟨10.1007/s10557-022-07328-w⟩
International audience; Purpose: AMG 986 is a novel apelin receptor (APJ) agonist that improves cardiac contractility in animal models without adversely impacting hemodynamics. This phase 1b study evaluated the safety/tolerability, pharmacokinetics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c1496524080225692356d28a4478ac
https://hal.archives-ouvertes.fr/hal-03656861
https://hal.archives-ouvertes.fr/hal-03656861
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100057-(2020)
Cell Reports Medicine
Cell Reports Medicine
Summary Experimental fibroblast growth factor 21 (FGF21) analogs can improve lipid profiles in patients with metabolic diseases. However, their effects on markers of insulin sensitivity appear to be minimal, potentially because of insufficient exposu
Publikováno v:
Journal of Cardiac Failure. 26:S68
Background Heart failure (HF) refers to a clinical condition in which the cardiac output is insufficient to meet the metabolic needs of the body and is marked by cardiac systolic and/or diastolic dysfunction. The apelin receptor (APJ) counteracts the
Autor:
Allegra Kaufman, Elizabeth C. Finger, Cheng Su, Winnie Sohn, Yi Hsiang Hsu, Mariano Janiszewski
Publikováno v:
Journal of the American College of Cardiology. 73:1755
Heterozygous carriers of a rare 12-base-pair deletion (del12), loss-of-function variant in the asialoglycoprotein receptor (ASGPR) subunit 1 ( ASGR1 ) had lower levels of non-high-density lipoprotein cholesterol, reduced risk for myocardial infarctio
Autor:
Sung Chang, Allegra Kaufman, Jaime Peña, Christian Graeff, Desmond Padhi, Claus-Christian Glüer, Cesar Libanati, Jan Borggrefe, Graeme M. Campbell
Publikováno v:
Bone. 81
Romosozumab inhibits sclerostin, thereby increasing bone formation and decreasing bone resorption. This dual effect of romosozumab leads to rapid and substantial increases in areal bone mineral density (aBMD) as measured by dual-energy X-ray absorpti
Autor:
Shauna Hutton, Graham Richard Jang, Desmond Padhi, Edward Lee, Lisa Hamilton, Allegra Kaufman, Ogo Egbuna
Publikováno v:
Pharmacology Research & Perspectives
Drug-disease interactions involving therapeutic proteins that target cytokines and potentially impact cytochrome P450 (CYP) enzymes have been of increased interest to drug regulatory agencies and industry sponsors in recent years. This parallel-group