The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases

Autor: Allardyce, C S, McDonagh, P D, Lian, L Y, Wolf, C R, Roberts, G C

Glutathione S-transferases (GSTs) play a key role in the metabolism of drugs and xenobiotics. To investigate the catalytic mechanism, substrate binding and catalysis by the wild-type and two mutants of GST A1-1 have been studied. Substitution of the

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https://europepmc.org/articles/PMC1220582/

The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases.

Autor: Allardyce CS; Centre for Mechanisms of Human Toxicity, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK., McDonagh PD, Lian LY, Wolf CR, Roberts GC

Publikováno v: The Biochemical journal [Biochem J] 1999 Nov 01; Vol. 343 Pt 3, pp. 525-31.