Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Allan Zajac"'
Autor:
Ryan, Zander, Moujtaba Y, Kasmani, Yao, Chen, Paytsar, Topchyan, Jian, Shen, Shikan, Zheng, Robert, Burns, Jennifer, Ingram, Can, Cui, Nikhil, Joshi, Joseph, Craft, Allan, Zajac, Weiguo, Cui
Publikováno v:
Immunity
CD4(+) T cell-derived interleukin 21 (IL-21) sustains CD8(+) T cell responses during chronic viral infection, but the helper subset that confers this protection remains unclear. Here, we applied scRNA and ATAC-seq approaches to determine the heteroge
Autor:
Ryan Zander, Moujtaba Y. Kasmani, Yao Chen, Paytsar Topchyan, Jian Shen, Shikan Zheng, Robert Burns, Jennifer Ingram, Can Cui, Nikhil Joshi, Joseph Craft, Allan Zajac, Weiguo Cui
Publikováno v:
Immunity. 55:475-493.e5
Publikováno v:
The Journal of Immunology. 194:200.8-200.8
The activation of naïve CD8 T cells typically results in the formation of effector (TE) cells as well as memory cells that are retained over time. Memory CD8 T cells can be further subdivided into central memory (TCM), effector memory (TEM) and tiss
Autor:
Daniel Silberger, Carlene Zindl, Carson Moseley, Craig Maynard, Bruce Vallance, Allan Zajac, Casey Weaver
Publikováno v:
The Journal of Immunology. 194:138.2-138.2
Interleukin-21 (IL-21) is critical for host defense against infections with intracellular and extracellular pathogens. Although most infections occur following an initial colonization at mucosal surfaces, no studies have addressed the role of IL-21 i
Publikováno v:
The Journal of Immunology. 194:134.5-134.5
The clearance and control of many intracellular pathogens and tumors rely on the development of efficacious CD8 T cell responses. These responses are functionally diverse, however, whether and how this heterogeneity forecasts effector formation, memo
Disparate regulatory roles for B cells during primary and secondary CD4 T cell responses (IRC3P.470)
Publikováno v:
The Journal of Immunology. 192:59.13-59.13
The generation of CD4 T cell memory is shaped by numerous factors, such as the strength and duration of TCR signaling, as well as the priming environment, all of which can be modified by B cells. Studies using B cell-deficient mice indicate B cells p
Publikováno v:
The Journal of Immunology. 192:65.3-65.3
Although anti-viral CD8 T cells display differences in their portfolios of effector functions, dissecting this ensemble has been impeded by the lack of effective methods for segregating, tracking, and defining these distinct subsets based upon their
Publikováno v:
Clinical Immunology. 131:S53-S54
Publikováno v:
The Journal of Immunology. 190:49.9-49.9
The eradication of various types of pathogens is mediated by the coordinated efforts of both effector CD4 and CD8 T cells. Following pathogen control, the majority of CD4 and CD8 T cell effector populations undergo apoptosis, but a subset of these ce
Publikováno v:
The Journal of Immunology. 190:191.4-191.4
Follicular regulatory T cells (TFR) are a regulatory CD4 (Treg) subset that suppress germinal center (GC) B cell differentiation. Interleukin 21 (IL-21) promotes T follicular helper (TFH) differentiation. In the present study we investigated the modu