Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Allan Y. Chen"'
Publikováno v:
J Radiosurg SBRT
Idiopathic glossopharyngeal neuralgia (GPN) is a rare disorder of the ninth cranial nerve characterized by severe paroxysmal pain affecting the ear, tongue and throat. Frame-based radiosurgery (SRS) has been shown to be an effective option. We report
Autor:
Allan Y. Chen, Thinh Chau
Publikováno v:
The Breast Journal. 24:221-222
Publikováno v:
Clinical Neurology and Neurosurgery. 110:968-972
Objective Due to the fundamental differences in treatment delivery, linear-accelerator-based radiosurgery can be complementary to Gamma Knife (GK) for intracranial lesions. We reviewed the effect of adding GK to an existing linear accelerator (Linac)
Publikováno v:
Journal of Neurosurgery. 105:69-74
ObjectStereotactic radiosurgery is beneficial for patients with a limited number of small brain metastases. Increased numbers of brain metastases, not infrequently at unreachable locations, are identified using thin-section magnetic resonance (MR) im
Publikováno v:
Cancer Research. 65:9194-9199
Ku86 is an integral component of the nonhomologous end-joining (NHEJ) pathway of cellular double-strand break repair. In the current study, we investigated the role of Ku86 in DNA topoisomerase I–mediated radiosensitization induced by camptothecin
Publikováno v:
Journal of Clinical Neuroscience. 12:242-245
Brain metastases occur in 15-20% of patients with cancer and are generally associated with an overall poor prognosis. Currently, radiotherapy and surgery are the mainstay of palliative therapy for patients with brain metastases, while the role of sys
Autor:
Allan Y. Chen, Shyh-Jen Shih, Liza N. Garriques, Mace L. Rothenberg, Michael Hsiao, Dennis P. Curran
Publikováno v:
Molecular Cancer Therapeutics. 4:317-324
The silatecan 7-tert-butyldimethylsilyl-10-hydroxy-camptothecin (DB-67) represents a new generation of camptothecin derivatives that exhibits a potent in vitro DNA topoisomerase I (TOP1)–mediated DNA-damaging activity, improved blood stability, and
Publikováno v:
Critical Reviews in Oncology/Hematology. 50:111-119
Since its discovery more than a century ago, ionizing radiation has become a mainstay therapy for patients suffering from cancers. Currently, radiotherapy provides cure or palliative care for approximately one half of the cancer population. The antic
Publikováno v:
Biochemistry. 40:3316-3323
The breakage/reunion reaction of DNA topoisomerase II (TOP2) can be interrupted by DNA intercalators (e.g., doxorubicin), enzyme binders (e.g., etoposide), or DNA lesions (e.g., abasic sites) to produce TOP2-mediated DNA damage. Here, we demonstrate
Publikováno v:
Annals of the New York Academy of Sciences. 922:298-300