Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Allan Watkinson"'
Autor:
Thomas R. Fuerst, Peter C. Fusco, Ashok Ganesan, Jeremy H. Lakey, Karie J. Hirst, Allan Watkinson, Chris S. LeButt, Kelly J. Fleetwood, Andrei Soliakov
Publikováno v:
Clinical and Vaccine Immunology. 20:1659-1668
Aluminum salts are the most widely used vaccine adjuvants, and phosphate is known to modulate antigen-adjuvant interactions. Here we report an unexpected role for phosphate buffer in an anthrax vaccine (SparVax) containing recombinant protective anti
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 82:475-484
Insoluble aggregation or precipitation is one of the most common degradation pathways observed for biotherapeutics; despite this, the structural mechanisms by which this occurs remain poorly understood due to difficulties associated with biophysical
Publikováno v:
Micron (Oxford, England : 1993). 93
Negatively stained transmission electron microscope images are presented that depict the aggregation of recombinant anthrax protective antigen (rPA83 monomer and the PA63 prepore oligomer) under varying in vitro biochemical conditions. Heat treatment
Autor:
Richard J. Lewis, Jeremy H. Lakey, Frank Depoix, J. Robin Harris, Allan Watkinson, Andrei Soliakov
Publikováno v:
Micron. 43:192-200
Aluminium-based vaccine adjuvants have been in use since the 1920s. Aluminium hydroxide (alum) that is the chemical basis of Alhydrogel, a widely used adjuvant, is a colloid that binds proteins to the particular surface for efficient presentation to
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 80:25-32
An anthrax sub-unit vaccine, comprising recombinant Protective Antigen (rPA83) and aluminium hydroxide adjuvant (Alhydrogel®) is currently being developed. Here, a series of biophysical techniques have been applied to free and adjuvant bound antigen
Publikováno v:
Vaccine. 28:5746-5754
Caf1 of the plague bacterium, Yersinia pestis is a polymeric virulence factor and vaccine component, formed from monomers by a donor strand exchange (DSE) mechanism. Here, EM images of Caf1 reveal flexible polymers up to 1.5 microm long (4MDa). The b
Autor:
Allan Watkinson
Publikováno v:
BioProcessing Journal. 5:24-28
Publikováno v:
International Journal of Cosmetic Science. 25:193-198
Removal of underarm hair is an intrinsic part of the care regimen for the majority of female consumers, with most using a wet shave with a disposable razor. However, little is known of the impact of shaving on axillary skin, and it is a particularly
Publikováno v:
Inflammation Research. 52:238-245
Objective and Design: In the present study we examined the effects of the cannabinoid receptor agonist HU210 on histamine-evoked somatosensory and vascular responses in humans. Subjects: Two sets of experiments were performed, in which twelve (Study
Publikováno v:
Pain. 102:283-288
The induction of hyperalgesia upon capsaicin administration requires activation of specific sub-classes of nociceptive afferent C-fibres providing nociceptive input to the central nervous system. It has been demonstrated in animal models that the end