Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trialResearch in context

Autor: Jesse Dawson, Michele Robertson, David Alexander Dickie, Phillip Bath, Kirsten Forbes, Terence Quinn, Niall M. Broomfield, Krishna Dani, Alex Doney, Graeme Houston, Kennedy R. Lees, Keith W. Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Alexander Dyker, Paul Guyler, Ahamad Hassan, Mark T. Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Alex McConnachie

Publikováno v: EClinicalMedicine, Vol 57, Iss , Pp 101863- (2023)

Summary: Background: People who experience an ischaemic stroke are at risk of recurrent vascular events, progression of cerebrovascular disease, and cognitive decline. We assessed whether allopurinol, a xanthine oxidase inhibitor, reduced white matte

Externí odkaz: https://doaj.org/article/6db3a982a110424586003c813c4bb452

The role of urate and xanthine oxidase in vascular oxidative stress: future directions

Autor: Jacob George, Allan Struthers

Publikováno v: Therapeutics and Clinical Risk Management, Vol 2009, Iss default, Pp 799-803 (2009)

Jacob George, Allan StruthersDivision of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UKAbstract: Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite c

Externí odkaz: https://doaj.org/article/9db0083e0ada4d9ca5b485eec556e018

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

Autor: Paul R Kalra, John G F Cleland, Mark C Petrie, Elizabeth A Thomson, Philip A Kalra, Iain B Squire, Fozia Z Ahmed, Abdallah Al-Mohammad, Peter J Cowburn, Paul W X Foley, Fraser J Graham, Alan G Japp, Rebecca E Lane, Ninian N Lang, Andrew J Ludman, Iain C Macdougall, Pierpaolo Pellicori, Robin Ray, Michele Robertson, Alison Seed, Ian Ford, John GF Cleland, Paul WX Foley, Nicholas Boon, Shannon Amoils, Callum Chapman, Thomas G Diness, John McMurray, Richard Mindham, Pamela Sandu, Claes C Strom, Maureen Travers, Robert Wilcox, Allan Struthers, Patrick Mark, Christopher Weir, Elena Cowan, Charlotte Turner, Rosalynn Austin, Paula Rogers, Badri Chandrasekaran, Eva Fraile, Lynsey Kyeremeh, Lorraine McGregor, Joanna Osmanska, Barbara Meyer, Faheem Ahmad, Jude Fisher, Christina Summersgill, Katarzyna Adeniji, Rajkumar Chinnadurai, Lisa Massimo, Clare Hardman, Daisy Sykes, Sarah Frank, Simon Smith, Mohamed Anwar, Beth Whittington, Vennessa Sookhoo, Sinead Lyons, Janet Middle, Kay Housley, Andrew Clark, Jeanne Bulemfu, Christopher Critoph, Victor Chong, Stephen Wood, Benjamin Szwejkowski, Chim Lang, Jackie Duff, Susan MacDonald, Rebekah Schiff, Patrick Donnelly, Thuraia Nageh, Swapna Kunhunny, Roy Gardner, Marion McAdam, Elizabeth McPherson, Prithwish Banerjee, Eleanor Sear, Nigel Edwards, Jason Glover, Clare Murphy, Justin Cooke, Charles Spencer, Mark Francis, Iain Matthews, Hayley McKie, Andrew Marshall, Janet Large, Jenny Stratford, Piers Clifford, Christopher Boos, Philip Keeling, Debbie Hughes, Aaron Wong, Deborah Jones, Alex James, Rhys Williams, Stephen Leslie, Jim Finlayson, Andrew Hannah, Philip Campbell, John Walsh, Jane Quinn, Susan Piper, Sheetal Patale, Preeti Gupta, Victor Sim, Lucy Knibbs, Kristopher Lyons, Lana Dixon, Colin Petrie, Yuk-ki Wong, Catherine Labinjoh, Simon Duckett, Ian Massey, Henry Savage, Sofia Matias, Jonaifah Ramirez, Charlotte Manisty, Ifza Hussain, Rajiv Sankaranarayanan, Gershan Davis, Samuel McClure, John Baxter, Eleanor Wicks, Jolanta Sobolewska, Jerry Murphy, Ahmed Elzayat, Alastair Cooke, Jay Wright, Simon Williams, Amal Muthumala, Parminder Chaggar, Sue Webber, Gethin Ellis, Mandie Welch, Sudantha Bulugahapitiya, Thomas Jackson, Tapesh Pakrashi, Ameet Bakhai, Vinodh Krishnamurthy, Reto Gamma, Susan Ellery, Geraint Jenkins, Gladdys Thomas, Angus Nightingale, Nicola Greenlaw, Kirsty Wetherall, Ross Clarke, Christopher Graham, Sharon Kean, Alan Stevenson, Robbie Wilson, Sarah Boyle, John McHugh, Lisa Hall, Joanne Woollard, Claire Brunton, Eleanor Dinnett, Amanda Reid, Serena Howe, Jill Nicholls, Anna Cunnington, Elizabeth Douglas, Margaret Fegen, Marc Jones, Sheila McGowan, Barbara Ross, Pamela Surtees, Debra Stuart

Publikováno v: The Lancet. 400:2199-2209

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9d13332efd162c59d06dddbfdb09ef8
https://doi.org/10.1016/s0140-6736(22)02083-9

Tayside Screening For Cardiac Events (TASCFORCE) study: a prospective cardiovascular risk screening study

Autor: Matthew A Lambert, J Graeme Houston, Roberta Littleford, Catherine A Fitton, Allan Struthers, Frank Sullivan, Stephen Gandy, Jill J F Belch

Publikováno v: BMJ open. 12(10)

PurposeRisk factor-based models struggle to accurately predict the development of cardiovascular disease (CVD) at the level of the individual. Ways of identifying people with low predicted risk who will develop CVD would allow stratified advice and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674e792ff5898f62ac5dd50757805c05
https://pubmed.ncbi.nlm.nih.gov/36270757

Linear Systems of Differential Equations

Autor: Allan Struthers, Merle C. Potter

Publikováno v: Differential Equations ISBN: 9783030205058

In Sect. 1.1, we considered how the amount of salt present in a system of two tanks can be modeled through a system of differential equations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7c2381951794b9de994b1b8b3d8d982
https://doi.org/10.1007/978-3-030-20506-5_3