Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Allan Siu"'
Supplementary Data from PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f59dc2af57f9cba75b04342933bbd6f
https://doi.org/10.1158/1535-7163.22484988
https://doi.org/10.1158/1535-7163.22484988
Using a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell growth and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differential activity on cancer versus normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2114d82382c17f8452f376325966dd
https://doi.org/10.1158/1535-7163.c.6531699.v1
https://doi.org/10.1158/1535-7163.c.6531699.v1
Autor:
Corey A. Scipione, Jenny Jongstra-Bilen, Jiro Ikeda, Allan Siu, Marwan G. Althagafi, Chanele K. Polenz, Sharon J. Hyduk, Saraf Karim, Kelly Tai, Myron I. Cybulsky
Publikováno v:
Journal of molecular and cellular cardiology. 156
One of the hallmarks of atherosclerosis is ongoing accumulation of macrophages in the artery intima beginning at disease onset. Monocyte recruitment contributes to increasing macrophage abundance at early stages of atherosclerosis. Although the chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46155e59f7ae67c8bcc8f44f60acfa77
https://pubmed.ncbi.nlm.nih.gov/33781821
https://pubmed.ncbi.nlm.nih.gov/33781821
Autor:
Michael J.B. Kutryk, Myron I. Cybulsky, Sajedabanu Patel, Ilya Mukovozov, Yaroslav Sokolskyy, Guang Ying Liu, Sharon J. Hyduk, Qiuwang Zhang, Allan Siu, Yi-Wei Huang, Lisa A. Robinson
Publikováno v:
The Journal of Immunology. 195:3334-3344
The secreted neurorepellent Slit2, acting through its transmembrane receptor, Roundabout (Robo)-1, inhibits chemotaxis of varied cell types, including leukocytes, endothelial cells, and vascular smooth muscle cells, toward diverse attractants. The ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debb6e39ad0112037961d581097191c6
https://doi.org/10.4049/jimmunol.1500640
https://doi.org/10.4049/jimmunol.1500640
Autor:
Jorge Plutzky, Motoi Ilyama, Jenny Jongstra-Bilen, Mian Chen, Andrew C. Lau, Peter O'Donnell, David S. Milstone, Su-Ning Zhu, Allan Siu, Tucker Collins, Saptarsi M. Haldar, Jonathan D. Brown, Vannessa M. Davis, Mayada F Basheer, Myron I. Cybulsky
Publikováno v:
Circulation Research. 117:166-177
Rationale: Human and murine Vcam1 promoters contain 2 adjacent nuclear factor-κB (NF-κB)–binding elements. Both are essential for cytokine-induced transcription of transiently transfected promoter–reporter constructs. However, the relevance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9208587574df00cc5766f0fa193101ca
https://doi.org/10.1161/circresaha.117.306666
https://doi.org/10.1161/circresaha.117.306666
Publikováno v:
Oncotarget
Allan Siu 1 , Carl Virtanen 2 and Jan Jongstra 1 1 Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Canada and Department of Immunology, University of Toronto, Toronto, Canada 2 Microarray Cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9c0b78cd82e33cd10bfa0ce7949713
http://europepmc.org/articles/PMC3282072
http://europepmc.org/articles/PMC3282072
Publikováno v:
Drug Resistance Updates. 14:203-211
Resistance to chemotherapeutic drugs is a significant clinical problem for the treatment of cancer patients and has been linked to the activation of survival pathways and expression of multidrug efflux transporters. Thus inhibition of these survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec1c4190209e516f178596c8d507380
https://doi.org/10.1016/j.drup.2011.04.002
https://doi.org/10.1016/j.drup.2011.04.002
Publikováno v:
Molecular Cancer Therapeutics. 9:2478-2487
Using a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell growth and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differential activity on cancer versus normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50176396a09099562ee2c6f7cfef91f
https://doi.org/10.1158/1535-7163.mct-10-0321
https://doi.org/10.1158/1535-7163.mct-10-0321
Autor:
Rickvinder Besla, Mark Roufaiel, Hisham Ibrahim, Haiyan Xiao, Andrew C. Lau, Marwan G. Althagafi, Myron I. Cybulsky, Kateryna O Cybulsky, Sharon J. Hyduk, Clinton S. Robbins, Sanjiv A. Luther, Allan Siu, Eric Gracey, Henry M. Becker, Sherine Ensan, Su-Ning Zhu, Jenny Jongstra-Bilen, Angela Li, Robert D. Inman, Kelly Tai
Publikováno v:
Nature immunology. 17(11)
Regions of the normal arterial intima predisposed to atherosclerosis are sites of ongoing monocyte trafficking and also contain resident myeloid cells with features of dendritic cells. However, the pathophysiological roles of these cells are poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e796ca9fae8b91603c7a4496a1cfdc
https://pubmed.ncbi.nlm.nih.gov/28518165
https://pubmed.ncbi.nlm.nih.gov/28518165
Autor:
Mark Roufaiel, Eric Gracey, Allan Siu, Su-Ning Zhu, Andrew Lau, Hisham Ibrahim, Marwan Althagafi, Kelly Tai, Sharon J Hyduk, Kateryna O Cybulsky, Sherine Ensan, Angela Li, Rickvinder Besla, Henry M Becker, Haiyan Xiao, Sanjiv A Luther, Robert D Inman, Clinton S Robbins, Jenny Jongstra-Bilen, Myron I Cybulsky
Publikováno v:
Nature Immunology. 18:705-705
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2dfb0b12bdb410415da44dd419d827
https://doi.org/10.1038/ni0617-705d
https://doi.org/10.1038/ni0617-705d