Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Allan Motyer"'
Autor:
Richard Ahn, Damjan Vukcevic, Allan Motyer, Joanne Nititham, David McG. Squire, Jill A. Hollenbach, Paul J. Norman, Eva Ellinghaus, Rajan P. Nair, Lam C. Tsoi, Jorge Oksenberg, John Foerster, Wolfgang Lieb, Stephan Weidinger, Andre Franke, James T. Elder, Eric Jorgenson, Stephen Leslie, Wilson Liao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells via interaction with HLA ligands. KIR genes, including KIR2DS1, KIR3DL1, and KIR3DS1 have previously been implicated in psoriasis susceptibility. However
Externí odkaz:
https://doaj.org/article/be5b01fa959f4f46af42fb1812d00ced
Autor:
Allan Motyer, Stacey Jackson, Bicheng Yang, Ivon Harliwong, Wei Tian, Wingin Shiu, Yunchang Shao, Bo Wang, Catriona McLean, Michael Barnett, Trevor J. Kilpatrick, Stephen Leslie, Justin P. Rubio
Neuroinflammation has been linked to DNA damage in multiple sclerosis (MS), but its impact on neural cell genomes at nucleotide resolution is unknown. To address this question, we performed single nucleus whole genome sequencing to determine the land
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d39c6969f1a8b9547f9b3957ad6dc091
https://doi.org/10.1101/2022.04.30.490132
https://doi.org/10.1101/2022.04.30.490132
Autor:
Lisa W. Datta, Eun Suk Jung, John D. Rioux, Dermot P.B. McGovern, Naser Ebrahim Daryani, Kyuyoung Song, Yuta Fuyuno, Garima Juyal, Matthias Hübenthal, Ajit Sood, Gabrielle Boucher, Behrooz Z. Alizadeh, Tobias L. Lenz, Byong Duk Ye, Reza Malekzadeh, Soumya Raychaudhuri, Atsushi Takahashi, Siew C. Ng, Frauke Degenhardt, David Ellinghaus, Tom H. Karlsen, Sunny Hwong, Mareike Wendorff, Junji Umeno, Suk-Kyun Yang, Gabriele Mayr, Keiko Yamazaki, Motohiro Esaki, Steven R. Brant, Simonas Juzenas, Rinse K. Weersma, Michiaki Kubo, B.K. Thelma, Esther A. Torres, Eva Ellinghaus, John Schembri, Vandana Midha, Pierre Ellul, David T. Okou, Elisa Rosati, Subra Kugathasan, Jae Hee Cheon, Talin Haritunians, Hesham ElAbd, Myhunghee Hong, Shifteh Abedian, Homayon Vahedi, Stefan Schreiber, Stephen Leslie, Allan Motyer
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, 30(5), 356-369. Oxford University Press
Human Molecular Genetics, 30(5), 356-369. Oxford University Press
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifically DRB1*01
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dd65243c5cace197efed557518c64f
Autor:
Vandana Midha, Pierre Ellul, Keiko Yamazaki, John Schembri, Steven R. Brant, B.K. Thelma, Dermot P.B. McGovern, Talin Haritunians, Soumya Raychaudhuri, Naser Ebrahim Daryani, Tom H. Karlsen, Ajit Sood, Suk-Kyun Yang, Mareike Wendorff, Siew C. Ng, Yuta Fuyuno, Rinse K. Weersma, Kyuyoung Song, Motohiro Esaki, Reza Malekzadeh, John D. Rioux, Garima Juyal, Atsushi Takahashi, Byong Duk Ye, Matthias Hübenthal, Gabriele Mayr, Junji Umeno, Frauke Degenhardt, Sunny H. Wong, Eun Suk Jung, Tobias L. Lenz, Simonas Juzenas, Michiaki Kubo, Esther A. Torres, David Ellinghaus, Eva Ellinghaus, Gabrielle Boucher, Behrooz Z. Alizadeh, David T. Okou, Lisa W. Datta, Elisa Rosati, Subra Kugathasan, Jae Hee Cheon, Myhunghee Hong, Stefan Schreiber, Hesham ElAbd, Shifteh Abedian, Homayon Vahedi, Stephen Leslie, Allan Motyer, Andre Franke
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD, and specifically DRB1*0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0f84d7ace4e0f3283857e98cc09ef2
https://doi.org/10.1101/2020.07.29.20162552
https://doi.org/10.1101/2020.07.29.20162552
Autor:
David McG. Squire, Allan Motyer, Richard Ahn, Joanne Nititham, Zhi-Ming Huang, Jorge R. Oksenberg, John Foerster, Wilson Liao, Stephen Leslie
We report the development of MHC*IMP, a method for imputing non-classical HLA and other genes in the human Major Histocompatibility Complex (MHC). We created a reference panel for 25 genes in the MHC using allele calls from Whole Genome Sequencing da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e918f9f6f04712742f03bf7a30754f95
https://doi.org/10.1101/2020.01.24.919191
https://doi.org/10.1101/2020.01.24.919191
Autor:
Xiaobin Wang, Manuel A. R. Ferreira, Shyamali C. Dharmage, David Martino, Damjan Vukcevic, Young-Ae Lee, Melanie C. Matheson, Kirsten Beyer, Sarah Ashley, Justine A. Ellis, Richard Saffery, Xiumei Hong, Lyle C. Gurrin, Birgit Kalb, Katrina J. Allen, Ingo Marenholz, Jennifer J. Koplin, Allan Motyer, Stephen Leslie
Publikováno v:
Clinical & Experimental Allergy. 47:217-223
Background Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genome-wide association study (GWAS) has been published. Objective To identify genetic variants associated with challenge proven peanut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6466dfe8a5bcda6a2f7f25786c3b85d
https://doi.org/10.1111/cea.12863
https://doi.org/10.1111/cea.12863
Autor:
Jared O'Connell, Olivier Delaneau, Allan Motyer, Samantha Welsh, Peter Donnelly, Mark Effingham, Naomi E. Allen, Jonathan Marchini, Gavin Band, Stephen Leslie, Clare Bycroft, Desislava Petkova, Damjan Vukcevic, Lloyd T. Elliott, Alan Young, Adrian Cortes, Colin Freeman, Gil McVean, Kevin Sharp
Publikováno v:
Nature. 562
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open resource is unique in its size a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9386e42760d236a7b69e31a433ba8c
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Derek J. Pappas, Jarek Meller, Pierre-Antoine Gourraud, Vanja Paunic, Antoine Lizee, Steven J. Mack, Jill A. Hollenbach, Damjan Vukcevic, Karl R. Beutner, Lue Ping Zhao, Jacek Biesiada, Xiuwen Zheng, Martin Maiers, Stephen Leslie, Allan Motyer, Kent D. Taylor
Publikováno v:
Pharmacogenomics Journal
Pharmacogenomics Journal, 2018, 18 (3), pp.367-376. ⟨10.1038/tpj.2017.7⟩
Pharmacogenomics Journal, Nature Publishing Group, 2018, 18 (3), pp.367-376. ⟨10.1038/tpj.2017.7⟩
The pharmacogenomics journal, vol 18, iss 3
Pharmacogenomics Journal, 2018, 18 (3), pp.367-376. ⟨10.1038/tpj.2017.7⟩
Pharmacogenomics Journal, Nature Publishing Group, 2018, 18 (3), pp.367-376. ⟨10.1038/tpj.2017.7⟩
The pharmacogenomics journal, vol 18, iss 3
International audience; Four single nucleotide polymorphism (SNP)-based human leukocyte antigen (HLA) imputation methods (e-HLA, HIBAG, HLA*IMP:02 and MAGPrediction) were trained using 1000 Genomes SNP and HLA genotypes and assessed for their ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f5c1b1a9ee04b977b40274ab6dd7c7
https://www.hal.inserm.fr/inserm-02155110
https://www.hal.inserm.fr/inserm-02155110
Autor:
Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T. Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrian Cortes, Samantha Welsh, Gil McVean, Stephen Leslie, Peter Donnelly, Jonathan Marchini
The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic and health-related information is available on each participant, making
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3402ec155d170e82be4cc2c2c9ee6b5e
https://doi.org/10.1101/166298
https://doi.org/10.1101/166298
Autor:
Lars Fugger, Gil McVean, Damjan Vukcevic, Calliope A. Dendrou, Alexander T. Dilthey, Stephen Leslie, Luke Jostins, Allan Motyer, Adrian Cortes, Peter Donnelly
Publikováno v:
Cortes, A, Dendrou, C A, Motyer, A, Jostins, L, Vukcevic, D, Dilthey, A, Donnelly, P, Leslie, S, Fugger, L & McVean, G 2017, ' Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank ', Nature Genetics, vol. 49, no. 9, pp. 1311-1318 . https://doi.org/10.1038/ng.3926
Nature genetics
Nature genetics
Genetic discovery from the multitude of phenotypes extractable from routine healthcare data has the ability to radically transform our understanding of the human phenome, thereby accelerating progress towards precision medicine. However, a critical q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2642eebb00d56ead653068017cc59c2
https://doi.org/10.1101/105122
https://doi.org/10.1101/105122