Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Allan Maroli"'
Autor:
Robert M. Day, Osamu Nemoto, Mayumi Komine, Mamitaro Ohtsuki, Allan Maroli, Peng Chen, Yukari Okubo, Rosemary Petric, Shinichi Imafuku
Publikováno v:
The Journal of Dermatology
Apremilast, an oral, small‐molecule phosphodiesterase 4 inhibitor, works intracellularly within immune cells to regulate inflammatory mediators. This phase 2b randomized, placebo‐controlled study evaluated efficacy and safety of apremilast among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d0cedbe1672a7906ad5ee826fc64d
https://doi.org/10.1111/1346-8138.13829
https://doi.org/10.1111/1346-8138.13829
Autor:
Shinichi Imafuku, Mayumi Komine, Yukari Okubo, Osamu Nemoto, Mamitaro Ohtsuki, Robert M. Day, Peng Chen, Allan Maroli
Publikováno v:
Journal of Dermatological Science. 86:e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c835a33c83d09d93f687f8ec44afe45
https://doi.org/10.1016/j.jdermsci.2017.02.022
https://doi.org/10.1016/j.jdermsci.2017.02.022
Publikováno v:
Clinical Pharmacokinetics. 33:39-46
Two phase I trials, each involving 16 healthy adult volunteers, were performed to investigate possible interactions between grepafloxacin and theophylline or warfarin. In the theophylline study, grepafloxacin 600 mg was administered once daily for 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128920d0466eb41979bad76f9a2f450a
https://doi.org/10.2165/00003088-199700331-00008
https://doi.org/10.2165/00003088-199700331-00008
Autor:
Nathan M. Bass, Steven L. Bramer, Allan Maroli, Erika Wolfe, John F. Flaherty, Constantin Efthymiopoulos, Kenneth A. Somberg
Publikováno v:
Clinical Pharmacokinetics. 33:25-31
The pharmacokinetics of grepafloxacin, a new broad spectrum fluoroquinolone antibiotic, were studied in 2 trials involving 14 healthy volunteers, 10 individuals with mild (Child-Pugh Class A) impairment of liver function, and 12 with moderate (Child-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7177dfde7d8705816e5e167ee2cdc1e7
https://doi.org/10.2165/00003088-199700331-00006
https://doi.org/10.2165/00003088-199700331-00006
Publikováno v:
Clinical Pharmacokinetics. 33:1-8
The pharmacokinetics of grepafloxacin in healthy male subjects following single oral administration of doses ranging from 200 to 1200 mg, and following repeated oral administration of 400 and 800 mg doses are reported. Plasma levels of grepafloxacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dc7b394ecc29c2a8d48216dd38b372
https://doi.org/10.2165/00003088-199700331-00003
https://doi.org/10.2165/00003088-199700331-00003
Publikováno v:
Clinical Pharmacokinetics. 33:9-17
The effects of age and gender on the pharmacokinetics of the oral fluoroquinolone grepafloxacin were examined in 48 healthy middle-aged and elderly individuals, of whom half were male and half were female. Participants were stratified into 4 groups (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02e1affd799af4099f727d3f63b90a3
https://doi.org/10.2165/00003088-199700331-00004
https://doi.org/10.2165/00003088-199700331-00004
Publikováno v:
Clinical pharmacokinetics. 33
Two open crossover studies were conducted to investigate the effects of food or concomitant treatment with the histamine H2-receptor antagonist famotidine on the pharmacokinetics of the new fluoroquinolone grepafloxacin. Each study involved 16 health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c758ad9b5651c5134589fa778eedf
https://pubmed.ncbi.nlm.nih.gov/9433652
https://pubmed.ncbi.nlm.nih.gov/9433652
Publikováno v:
Clinical pharmacokinetics. 33
Grepafloxacin is mainly (approximately 90%) excreted by nonrenal mechanisms. The effect of renal impairment on the pharmacokinetics of grepafloxacin was evaluated in an open-label study involving 20 adults, 15 of whom had some degree of renal impairm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b320c37a1efad1f102f2178fb4da7053
https://pubmed.ncbi.nlm.nih.gov/9433654
https://pubmed.ncbi.nlm.nih.gov/9433654