Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Allan M Goldstein"'
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-6 (2024)
Abstract Neuroblastoma is the most common extracranial solid tumor in children, and a leading cause of childhood cancer deaths. All neuroblastomas arise from neural crest-derived sympathetic neuronal progenitors, but numerous mutations, the most comm
Externí odkaz:
https://doaj.org/article/94b24b4a1f3548b1b3c33187d8d07cd4
Autor:
Weikang Pan, Ahmed A. Rahman, Takahiro Ohkura, Rhian Stavely, Kensuke Ohishi, Christopher Y. Han, Abigail Leavitt, Aki Kashiwagi, Alan J. Burns, Allan M. Goldstein, Ryo Hotta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a
Externí odkaz:
https://doaj.org/article/a79ce412a55e45d297b62f324b8dce20
Autor:
Jay R Thiagarajah, Hasan Yildiz, Taylor Carlson, Alyssa R Thomas, Casey Steiger, Alberto Pieretti, Lawrence R Zukerberg, Rebecca L Carrier, Allan M Goldstein
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99944 (2014)
Hirschsprung disease-associated enterocolitis (HAEC) leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to pla
Externí odkaz:
https://doaj.org/article/23d178212d11413c92936cc0938cd30c
Autor:
Kelly L. Buchanan, Robert M. Wilechansky, Mythili P. Pathipati, Allan M. Goldstein, Daniel P. Ryan, Joseph C. Yarze
Publikováno v:
Frontiers in Gastroenterology, Vol 3 (2024)
A 21-year-old man presented with severe abdominal pain four days after undergoing upper endoscopy with duodenal biopsies and was found to have an intramural duodenal hematoma. Symptoms progressed after attempts at diet advancement, and repeat imaging
Externí odkaz:
https://doaj.org/article/d5f6335b39e74a3b9a459563b6a9f1af
Autor:
Ahmed A. Rahman, Rhian Stavely, Weikang Pan, Leah Ott, Kensuke Ohishi, Takahiro Ohkura, Christopher Han, Ryo Hotta, Allan M. Goldstein
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 907-921 (2024)
Background & Aims: Intestinal inflammation is associated with loss of enteric cholinergic neurons. Given the systemic anti-inflammatory role of cholinergic innervation, we hypothesized that enteric cholinergic neurons similarly possess anti-inflammat
Externí odkaz:
https://doaj.org/article/9f96d67dcc0845259cc01b9f26ac6f70
Autor:
Nanda Nanthakumar, Di Meng, Allan M Goldstein, Weishu Zhu, Lei Lu, Ricardo Uauy, Adolfo Llanos, Erika C Claud, W Allan Walker
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17776 (2011)
Necrotizing enterocolitis (NEC) is a devastating neonatal intestinal inflammatory disease, occurring primarily in premature infants, causing significant morbidity and mortality. The pathogenesis of NEC is associated with an excessive inflammatory IL-
Externí odkaz:
https://doaj.org/article/e967c28133dc45888393c533eae44fa8
Autor:
Ryo Hotta, Ahmed Rahman, Sukhada Bhave, Rhian Stavely, Weikang Pan, Shriya Srinivasan, Geoffrey de Couto, Luis Rodriguez-Borlado, Richard Myers, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Enteric neuropathies, which result from abnormalities of the enteric nervous system, are associated with significant morbidity and high health-care costs, but current treatments are unsatisfactory. Cell-based therapy offers an inn
Externí odkaz:
https://doaj.org/article/3507b616264b4da0a5ab836cf0ab4178
Autor:
Richard A. Guyer, Nicole Picard, Jessica L. Mueller, Kensuke Ohishi, Abigail Leavitt, Andrew J. Murphy, Kristine M. Cornejo, Ryo Hotta, Allan M. Goldstein
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/4c7a37fb29a5493388583857495fd4f6
Autor:
Ryo Hotta, Weikang Pan, Sukhada Bhave, Nandor Nagy, Rhian Stavely, Takahiro Ohkura, Kumar Krishnan, Geoffrey de Couto, Richard Myers, Luis Rodriguez-Borlado, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Cell Transplantation, Vol 32 (2023)
The enteric nervous system (ENS) is an extensive network of neurons and glia within the wall of the gastrointestinal (GI) tract that regulates many essential GI functions. Consequently, disorders of the ENS due to developmental defects, inflammation,
Externí odkaz:
https://doaj.org/article/2be94383c769473181d73fdc2d28dfb1
Autor:
Richard A. Guyer, Rhian Stavely, Keiramarie Robertson, Sukhada Bhave, Jessica L. Mueller, Nicole M. Picard, Ryo Hotta, Julia A. Kaltschmidt, Allan M. Goldstein
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112194- (2023)
Summary: The enteric nervous system (ENS) consists of glial cells (EGCs) and neurons derived from neural crest precursors. EGCs retain capacity for large-scale neurogenesis in culture, and in vivo lineage tracing has identified neurons derived from g
Externí odkaz:
https://doaj.org/article/341cb57d221b46b58225294c16e22a7f