Výsledky vyhledávání - "Allan J. Yates"

Primary Neurosurgery for Pediatric Low-Grade Gliomas: A Prospective Multi-Institutional Study From the Children's Oncology Group

Autor: Richard Sposto, Linda Heier, Peter C. Burger, Robert A. Sanford, Allan J. Yates, Jeffrey H. Wisoff, Emiko J. Holmes, Larry E. Kun

Publikováno v: Neurosurgery. 68:1548-1555

Background Central nervous system neoplasms are the most common solid tumors in children, and more than 40% are low-grade gliomas. Variable locations, extent of resection, postoperative neurodiagnostic evaluation, and histology have confounded therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2c76f7b8cc053960bbc05615efe8b
https://doi.org/10.1227/neu.0b013e318214a66e

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Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues

Autor: Michael C. Frühwald, Christoph Plass, Allan J. Yates, Dominic J. Smiraglia, Srimoyee Ghosh, Jeffrey C. Miecznikowski

Publikováno v: Epigenetics. 5:527-538

Although most CpG islands are generally thought to remain unmethylated in all adult somatic tissues, recent genome-wide approaches have found that some CpG islands have distinct methylation patterns in various tissues, with most differences being see

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b26d3e987c028ffc85638ccbf2f74a
https://doi.org/10.4161/epi.5.6.12228

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Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant astrocytoma: Outcome compared with conventional chemotherapy: A report from the Children's Oncology Group

Autor: Dana Wallace, James M. Boyett, Roger J. Packer, Ian F. Pollack, Philip Stanley, Sharon Gardner, Stewart Goldman, Marc K. Rosenblum, Jonathan L. Finlay, Ira J. Dunkel, Allan J. Yates, Girish Dhall, Robert A. Zimmerman

Publikováno v: Pediatric Blood & Cancer. 51:806-811

Purpose—Children and adolescents with malignant astrocytomas recurring after initial treatment have a dismal prognosis, with only rare patients surviving one year beyond recurrence. The purpose of this study was to attempt to improve their survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d163bb917c2098da7c7782b4c6d651cd
https://doi.org/10.1002/pbc.21732

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Rarity ofPTENdeletions andEGFRamplification in malignant gliomas of childhood: results from the Children’s Cancer Group 945 cohort

Autor: Emiko J. Holmes, Jonathan L. Finlay, Judith Burnham, Tianni Zhou, Allan J. Yates, Ian F. Pollack, Sydney D. Finkelstein, C. David James, Ronald L. Hamilton

Publikováno v: Journal of Neurosurgery: Pediatrics. 105:418-424

In reporting on molecular studies involving malignant gliomas in adults, authors have noted that deletions of PTEN and amplification of EGFR are common and may contribute to tumor development, providing a rationale for a number of therapies aimed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353118e9f6c92ff19067cbbd6c401176
https://doi.org/10.3171/ped.2006.105.5.418

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Molecular Mechanisms of GD3-Induced Apoptosis in U-1242 MG Glioma Cells

Autor: H. E. Saqr, Ola M. Omran, Allan J. Yates

Publikováno v: Neurochemical Research. 31:1171-1180

An increasing amount of evidence indicates that the disialoganglioside GD3 is involved in apoptosis in many cell lines. Our previous studies demonstrated that endogenous GD3 expression induced apoptosis in U-1242 MG glioma cells transfected with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b56366d79d6a211c51ef2d71ab57e49
https://doi.org/10.1007/s11064-006-9147-2

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O6-Methylguanine-DNA Methyltransferase Expression Strongly Correlates With Outcome in Childhood Malignant Gliomas: Results From the CCG-945 Cohort

Autor: Allan J. Yates, Judith Burnham, Ronald L. Hamilton, Tianni Zhou, Emiko J. Holmes, Ian F. Pollack, Jonathan L. Finlay, Robert W. Sobol

Publikováno v: Journal of Clinical Oncology. 24:3431-3437

Purpose O6-Methylguanine-DNA methyltransferase (MGMT) functions to counteract the cytotoxic effects of alkylating agents, such as nitrosoureas, which play a central role in the treatment of childhood malignant gliomas. Epigenetic silencing of MGMT ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599dda49e444dde33f33938458d2fa06
https://doi.org/10.1200/jco.2006.05.7265

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TRAIL-Induced Apoptosis in U-1242 MG Glioma Cells

Autor: H. E. Saqr, Allan J. Yates, Ola M. Omran, J. L. Oblinger

Publikováno v: Journal of Neuropathology and Experimental Neurology. 65:152-161

Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis in U-1242 MG cells. To investigate the molecular events involved in this process, we studied the effects of TRAIL on the localization within membrane fractions of molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287511f74bf768c2d7fe52839d036db8
https://doi.org/10.1097/01.jnen.0000199574.86170.80

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Essential Role of E2-25K/Hip-2 in Mediating Amyloid-β Neurotoxicity

Autor: Allan J. Yates, Yeon-Mi Hong, Soo Jung Seo, Jae-Young Koh, Chul Woong Chung, Soyoung Kim, Joo Yong Lee, Dong-Gyu Jo, Yung Joon Yoo, Sang Mi Shim, Hidenori Ichijo, Sungmin Song, Min Chul Lee, Yong-Keun Jung

Publikováno v: Molecular Cell. 12:553-563

The ubiquitin/proteasome system has been proposed to play an important role in Alzheimer's disease (AD) pathogenesis. However, the critical factor(s) modulating both amyloid-beta peptide (Abeta) neurotoxicity and ubiquitin/proteasome system in AD are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1828a2497cb55c02532c4dceb14430c
https://doi.org/10.1016/j.molcel.2003.08.005

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