Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Allan J. McLean"'
Publikováno v:
Australasian Journal on Ageing. 26:45-51
Objectives:To analyse the site-specific epidemiology of hip fracture (HF) for the ACT and to project HF up to 2051. Methods:Age- and sex-specific rates of HF and projections of the number of HFs were calculated by applying the age- and sex-specific r
Autor:
Robin Fraser, David G. Le Couteur, Alessandra Warren, Victoria C. Cogger, Allan J. McLean, Patrick Bertolino
Publikováno v:
Experimental Gerontology. 40:807-812
Age-related changes in the hepatic sinusoid of the rat, human and baboons called pseudocapillarization have been discovered and are important because they are considered to be implicated in the pathogenesis of some age-related diseases. In this study
Publikováno v:
Australasian Journal on Ageing. 24:98-102
Objectives: To determine the incidence and consequences of falls in elderly people living in hostels, and the role of comorbidity, orthostatic hypotension and medications as risk factors for falls. Methods: Cross-sectional prevalence and event associ
Publikováno v:
Clinical Pharmacokinetics. 44:187-200
The fenestrated sinusoidal endothelium ('liver sieve') and space of Disse in the healthy liver do not impede the transfer of most substrates, including drugs and oxygen, from the sinusoidal lumen to the hepatocyte. Plasma components transfer freely i
Autor:
David G. Le Couteur, Robin Fraser, David R. Sullivan, Victoria C. Cogger, Allan J. McLean, Sarah N. Hilmer
Publikováno v:
Hepatology. 42:1349-1354
The mechanisms for the association of old age with post-prandial hyperlipidemia and atherosclerosis are not well understood. Post-prandial hyperlipidemia has emerged as a significant risk for atherosclerosis. The liver is the central organ for lipopr
Autor:
Michael Muller, Robin Fraser, Jameel Khan, Victoria C. Cogger, David G. Le Couteur, Allan J. McLean
Publikováno v:
Journal of Hepatology. 41:370-376
Background/Aims Oxidative stress is implicated in the pathogenesis of age-related and disease-associated changes in the hepatic sinusoid. We studied the effects of oxidative stress on the morphology of the liver, focusing specifically on the hepatic
Autor:
Allan J. McLean, David G. Le Couteur
Publikováno v:
Pharmacological Reviews. 56:163-184
Population aging evokes doomsday economic and sociological prognostication, despite a minority of older people suffering significant dependency and the potential for advances in therapeutics of age-related disease and primary aging. Biological aging
Publikováno v:
The Japanese Journal of Physiology. 54:421-429
Wash-in experiments, which may be useful for the study of the disposition of substrates in the liver, have not been well described. To investigate physiological models for wash-in curves, we performed experiments on the perfused livers of male Wistar
Autor:
Philip W. Kuchel, Muireann Coen, Allan J. McLean, Jill E. Gready, Saadallah Ramadan, Peta J. Harvey, David J. Philp, William A. Bubb, J Hook, Bogdan E. Chapman
Publikováno v:
Magnetic Resonance in Medicine. 52:663-668
31P magic angle spinning NMR (MAS-NMR) spectra were obtained from suspensions of human red blood cells (RBCs) that contained the cell-volume-sensitive probe molecule, dimethyl methylphosphonate (DMMP). A mathematical representation of the spectral-pe
Autor:
Alessandra Warren, Jane E. Dahlstrom, Victoria C. Cogger, David G. Le Couteur, Guan C Chong, Allan J. McLean, Astrid M.A. Markus
Publikováno v:
The Journal of Pathology. 200:112-117
Age-related changes in liver function are important because they may promote susceptibility to adverse drug reactions, neurotoxicity, atherosclerosis, and other important diseases in older people. Age-related changes in the rat hepatic sinusoidal end