Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Allan J Tobin"'
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 3, Pp 546-555 (2004)
We have developed a medium-throughput cell-based assay to screen drugs for Huntington's disease (HD). The assay measures the ability of drugs to protect cultured neuronal (PC12) cells from death caused by an expanded polyglutamine (poly Q) form of hu
Externí odkaz:
https://doaj.org/article/4cafa4e376b1465d953708cefdb0b5ce
Autor:
Liliana B Menalled, Monica Patry, Natalie Ragland, Phillip A S Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J Tobin, Daniela Brunner
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9793 (2010)
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and test
Externí odkaz:
https://doaj.org/article/4fa4ff5e21dd404d8e4ec783503ea5d3
Autor:
Igor Koval, Thomas Dighiero-Brecht, Allan J. Tobin, Sarah J. Tabrizi, Rachael I. Scahill, Sophie Tezenas du Montcel, Stanley Durrleman, Alexandra Durr
Publikováno v:
Scientific Reports
Scientific Reports, 2022, 12 (1), pp.18928. ⟨10.1038/s41598-022-18848-8⟩
Scientific Reports, 2022, 12 (1), pp.18928. ⟨10.1038/s41598-022-18848-8⟩
Variability in neurodegenerative disease progression poses great challenges for the evaluation of potential treatments. Identifying the persons who will experience significant progression in the short term is key for the implementation of trials with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda17824407c840b011b487d60f78411
https://inria.hal.science/hal-03877293
https://inria.hal.science/hal-03877293
Autor:
Stanley Durrleman, Rachael I. Scahill, Allan J. Tobin, Igor Koval, Sarah J. Tabrizi, Alexandra Durr, Dighiero-Brecht T
We propose a new approach, based on machine learning, to evaluating new treatments for neurodegenerative diseases. Using data from two longitudinal studies of 299 participants with early Huntington Disease, we learned the range of likely trajectories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9435f89e1d5f303b8d12bbb3ac63b14c
https://doi.org/10.21203/rs.3.rs-264531/v1
https://doi.org/10.21203/rs.3.rs-264531/v1
Autor:
John H. Warner, Allan J. Tobin, Blair R. Leavitt, Chris Becker, Howard Schulman, Raymund A.C. Roos, Sarah J. Tabrizi, Cristina Sampaio, Alexandra Durr, Beth Borowsky
Publikováno v:
Neurology, 80(21), 1934-1941
Objective: To evaluate plasma 8-hydroxy-deoxy-guanosine (8OHdG) levels as a potential biomarker of premanifest and early Huntington disease (HD). Methods: Personnel from 2 independent laboratories quantified 8OHdG in blinded longitudinal plasma sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f102e1688faa13abc8bceb860f1de39a
https://doi.org/10.1212/wnl.0b013e318293e1a1
https://doi.org/10.1212/wnl.0b013e318293e1a1
Autor:
Mayte Suárez-Fariñas, Liliana B. Menalled, Christina Leahy, Larry Park, Allan J. Tobin, Ethan Signer, Vanessa C. Wheeler, Monica Patry, Daniela Brunner, Marcy E. MacDonald, Janet M. Leeds, A. Jennifer Morton, X. William Yang, David Howland, Bassem F. El-Khodor, GP Bates, Benjamin Zahasky, Samantha J. Orenstein
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557ce41620d6b4eb0ad112bf58a91534
https://doi.org/10.1016/j.nbd.2009.05.007
https://doi.org/10.1016/j.nbd.2009.05.007
Autor:
Allan J. Tobin, R. D. Mehra, L. Vician, A. Erickson, Niranjala J.K. Tillakaratne, Anita E. Hendrickson, Monique Esclapez
Publikováno v:
The Journal of Comparative Neurology. 343:566-581
Adult monkey primary visual cortex contains a diverse population of stellate neurons that utilize the neurotransmitter gamma aminobutyric acid (GABA). Two glutamic acid decarboxylase (GAD) enzymes that synthesize GABA, GAD65 and GAD67, were localized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c730406e66d1070e98b7109d759eebb
https://doi.org/10.1002/cne.903430407
https://doi.org/10.1002/cne.903430407
Publikováno v:
The Journal of Physical Chemistry B. 108:9325-9332
The photoinduced electron transfer between immobilized thionine and the dinucleotide enzyme cofactors NADH and NADPH in a SiO2 sol−gel matrix is reported. The electron-transfer quenching of thionine luminescence is used to monitor the rate of NADPH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc6341180361ade4f7e082f1e62491e
https://doi.org/10.1021/jp038051g
https://doi.org/10.1021/jp038051g
Autor:
Hadi Shojaeian Zanjani, Michael W. Vogel, Robert P. McMahon, Jean Mariani, Andrei Blokhin, Niranjala J.K. Tillakaratne, Y. Lemaigre-Dubreuil, Allan J. Tobin
Publikováno v:
Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 2004, 475, pp.481-492. ⟨10.1002/cne.20196⟩
Journal of Comparative Neurology, 2004, 475, pp.481-492. ⟨10.1002/cne.20196⟩
Journal of Comparative Neurology, Wiley, 2004, 475, pp.481-492. ⟨10.1002/cne.20196⟩
Journal of Comparative Neurology, 2004, 475, pp.481-492. ⟨10.1002/cne.20196⟩
The number of cerebellar Purkinje cells is increased by over 40% in young transgenic mice that overexpress a human Bcl-2 transgene (Hu-Bcl-2). To determine whether the Bcl-2-mediated rescue of Purkinje cells persists through life, the numbers of Purk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a94a559915c18e693f527bac3e3d2b
https://doi.org/10.1002/cne.20196
https://doi.org/10.1002/cne.20196
Autor:
Jose Segovia, George M. Lawless, Allan J. Tobin, Michael Brenner, Niranjala J.K. Tillakaratne
Publikováno v:
Journal of Neurochemistry. 63:1218-1225
C6 cells express proteins and mRNAs that are characteristic of both glia and neurons. Agents that increase intracellular levels of cyclic AMP (cAMP) decrease the enzymatic activity of glutamate decarboxylase (GAD), a neuronal marker, and the mRNA lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bb810c444c6ab5c8446ea1baf9c2fc
https://doi.org/10.1046/j.1471-4159.1994.63041218.x
https://doi.org/10.1046/j.1471-4159.1994.63041218.x